Faculty

Prefrontal cortex; interneurons; Novel pharmacology; Alcohol use disorders & affective disorders

Dr. Joglekar's lab has recently made significant progress in the area of T cell antigen discovery. A novel high-throughput approach developed by us has demonstrated the ability to identify the target antigen of a given T cell. Dr. Joglekar's lab proposes to use this platform to address major questions in Immunology: What is the breadth of the T cell response in a given disease? How do the antigenic landscapes of T cell responses evolve over time? And What is the fundamental mechanistic basis of antigen recognition by TCRs?

*Currently accepting graduate students

Dr. Jurczak’s lab is primarily interested in the relationship between nutrient excess, mitochondrial overload and the pathogenesis of metabolic diseases, such as fatty liver, insulin resistance and type 2 diabetes. Mitochondrial dysfunction and ectopic lipid accumulation in liver are both associated with insulin resistance in human subjects, but the cause and effect nature of these associations remain unclear. Dr. Jurczak’s lab is specifically interested in a mitochondrial repair mechanism called mitophagy that regulates the selective removal of damaged mitochondria via the autophagosomal pathway.

*Currently accepting graduate students