Liver 'organ on a chip' in Experimental Cell Research by Colin Beckwitt
August 1, 2019

From the article in Experimental Cell Research: The liver plays critical roles in both homeostasis and pathology. It is the major site of drug metabolism in the body and, as such, a common target for drug-induced toxicity and is... [ read more ] [ link to publication ]

The Zebrafish Cytochrome b5/Cytochrome b5 Reductase/NADH System Efficiently Reduces Cytoglobins 1 and 2: Conserved Activity of Cytochrome b5/Cytochrome b5 Reductases during Vertebrate Evolution in Biochemistry by Matthew Amdahl
July 23, 2019

From the article in Biochemistry: Cytoglobin is a heme protein evolutionarily related to hemoglobin and myoglobin. Cytoglobin is expressed ubiquitously in mammalian tissues; however, its physiological functions are yet... [ read more ] [ link to publication ]

Cutaneous TRPV1+ Neurons Trigger Protective Innate Type 17 Anticipatory Immunity in Cell by Jonathan Cohen
July 19, 2019

From the article in Cell: Cutaneous TRPV1+ neurons directly sense noxious stimuli, inflammatory cytokines, and pathogen-associated molecules and are required for innate immunity against some skin pathogens. Important unanswered... [ read more ] [ link to publication ]

Financial Implications of 12-Month Dispensing of Oral Contraceptive Pills in the Veterans Affairs Health Care System in JAMA Internal Medicine by Colleen Judge-Golden
July 8, 2019

From the article in JAMA Internal Medicine: Based on the outcomes of this model, adoption of a 12-month dispensing option for oral contraceptive pills may support reproductive autonomy and improve reproductive outcomes among women... [ read more ] [ link to publication ]

Markers of glutamate and GABA neurotransmission in the prefrontal cortex of schizophrenia subjects: Disease effects differ across anatomical levels of resolution by Samuel Dienel
July 8, 2019

From the article: Cognitive dysfunction in individuals with schizophrenia is thought to reflect, at least in part, altered levels of excitatory and inhibitory neurotransmission in the dorsolateral prefrontal cortex (DLPFC). Studies of the... [ read more ] [ link to publication ]

FGFR4 overexpression and hotspot mutations in metastatic ER+ breast cancer are enriched in the lobular subtype by Kevin Levine
June 27, 2019

From the article: Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that requires novel therapies in the advanced setting. To study acquired resistance to endocrine therapy in ILC, we have recently performed RNA-... [ read more ] [ link to publication ]

Endovascular management of spontaneous rupture of the left subclavian artery by Edgar Aranda-Michel
June 18, 2019

From the article: Spontaneous rupture of the left subclavian artery is a rare condition that requires immediate surgical intervention. A 21‐year‐old man with a history of membranoproliferative glomerulonephritis, failed... [ read more ] [ link to publication ]

Hypoalbuminemia in patients undergoing transcatheter aortic valve replacement: culprit or surrogate? by Edgar Aranda-Michel
May 1, 2019

From the article: Transcatheter aortic valve replacement (TAVR) is an area of rapid advancement in cardiac surgery. Through subsequent randomized controlled trials, its indications have broadened and its use steadily increased (... [ read more ] [ link to publication ]

Aperture and Suspensory Fixation Equally Efficacious for Quadriceps Tendon Graft Fixation in Primary ACL Reconstruction: A Systematic Review by Raphael Crum
April 8, 2019

From the article: This review is aimed to compare suspensory and aperture quadriceps tendon autograft femoral and tibial fixations in primary anterior cruciate ligament reconstruction (ACL-R), and the clinical outcomes and complication... [ read more ] [ link to publication ]

Temporal Dynamics of Shape Processing Differentiate Contributions of Dorsal and Ventral Visual Pathways by Elliot Collins
March 18, 2019

From the article: Although shape perception is primarily considered a function of the ventral visual pathway, previous research has shown... [ read more ] [ link to publication ]

Is Schimmelpenning Syndrome Associated with Intracranial Tumors? A Case Report. by Michael Chiang
March 15, 2019

In the article: Schimmelpenning syndrome is a rare, well-defined constellation of clinical phenotypes associated with the presence of nevus sebaceous and multisystem abnormalities most commonly manifested as cerebral, ocular, and skeletal... [ read more ] [ link to publication ]

mTOR inhibition affects Yap1-β-catenin-induced hepatoblastoma growth and development by Laura Molina
February 19, 2019

From the article: Hepatoblastoma (HB) is the most common pediatric liver malignancy. Around 80% of HB demonstrate simultaneous activation of β-catenin and Yes-associated protein 1 (Yap1). The mechanism by which these signaling pathways... [ read more ] [ link to publication ]

Baseline and follow-up activity and functional connectivity in reward neural circuitries in offspring at risk for bipolar disorder by Heather Acuff
February 13, 2019

From the article: Bipolar disorder (BD) is a serious psychiatric illness with demonstrated abnormalities in reward processing circuitry. Examining this circuitry in youth at familial risk for BD may provide further insight into the... [ read more ] [ link to publication ]

Bridging large-scale neuronal recordings and large-scale network models using dimensionality reduction by Ryan Williamson
January 22, 2019

From the article: A long-standing goal in neuroscience has been to bring together neuronal recordings and neural network modeling to... [ read more ] [ link to publication ]

White matter – emotion processing activity relationships in youth offspring of bipolar parents by Heather Acuff
January 15, 2019

From the article:
Background Early detection of Bipolar Disorder (BD) is critical for targeting interventions to delay or prevent illness onset. Yet, the absence of objective BD...
[ read more ] [ link to publication ]

Exclusive use of fixed pressure valves for cerebrospinal fluid diversion in a modern adult cohort by Michael Chiang
December 1, 2018

From the article:
Background: There is extensive debate on the role of fixed pressure shunts in the adult...
[ read more ] [ link to publication ]

Electrophiles modulate glutathione reductase activity via alkylation and upregulation of glutathione biosynthesis by Soma Jobbagy
November 22, 2018

From the article: Cells evolved robust homeostatic mechanisms to protect against oxidation or alkylation by electrophilic species. Glutathione (GSH) is the most abundant intracellular thiol, protects cellular components from oxidation and... [ read more ] [ link to publication ]

Statin drugs to reduce breast cancer recurrence and mortality by Colin Beckwitt
November 20, 2018

From the article: Epidemiologic studies have, variably, shown the concomitant use of statin drugs to be beneficial to cancer outcomes. Statin drugs have been FDA approved for three decades for the... [ read more ] [ link to publication ]

Statins attenuate outgrowth of breast cancer metastases by Colin Beckwitt
October 1, 2018

From the article:
BACKGROUND: Metastasis in breast cancer foreshadows mortality, as clinically evident disease is aggressive and generally chemoresistant. Disseminated breast cancer cells often enter a...
[ read more ] [ link to publication ]

The Association between Mental Health Disorders and History of Unintended Pregnancy among Women Veterans by Colleen Judge-Golden
September 5, 2018

From the article:
BACKGROUND: Women Veterans have high rates of mental health disorders and other psychosocial factors which may render this population particularly vulnerable to negative health outcomes associated with unintended...
[ read more ] [ link to publication ]

Evolving systems biology approaches to understanding non-coding RNAs in pulmonary hypertension by Lloyd Harvey
September 2, 2018

From the article: Our appreciation of the roles of non-coding RNAs, in particular microRNAs, in the manifestation of pulmonary hypertension (PH) has advanced considerably over the past decade. Comprised of small nucleotide sequences,... [ read more ] [ link to publication ]

Mitochondrial metabolism in pulmonary hypertension: beyond mountains there are mountains by MIranda Culley
August 31, 2018

From the article: Pulmonary hypertension (PH) is a heterogeneous and fatal disease of the lung vasculature, where metabolic and mitochondrial dysfunction may drive pathogenesis. Similar to the Warburg effect in cancer, a shift from... [ read more ] [ link to publication ]

Hepatocyte-Derived Lipocalin 2 Is a Potential Serum Biomarker Reflecting Tumor Burden in Hepatoblastoma by Laura Molina
August 1, 2018

From the article: Hepatoblastoma (HB) is the most common pediatric liver malignant tumor. Previously, we reported co-activation of β-catenin and Yes-associated protein-1 (YAP1) in 80% of HB. Hepatic co-expression of active β-catenin and... [ read more ] [ link to publication ]

Aiming for the target: Mitochondrial drug delivery in traumatic brain injury by Andrew Lamade
July 30, 2018

From the article: Mitochondria are a keystone of neuronal function, serving a dual role as sustainer of life and harbinger of death. While mitochondria are indispensable for energy production, a dysregulated mitochondrial network can spell... [ read more ] [ link to publication ]

Distinct neural processes for the perception of familiar versus unfamiliar faces along the visual hierarchy revealed by EEG by Elliot Collins
June 30, 2018

From the article: Humans recognize faces with ease, despite the complexity of the task and of the visual system which underlies it. Different spatial regions, including both the core and extended face processing networks, and distinct... [ read more ] [ link to publication ]

Alterations in cortical interneurons and cognitive function in schizophrenia by Samuel Dienel
June 22, 2018

From the article: Certain clinical features of schizophrenia, such as working memory disturbances, appear to emerge from altered gamma oscillatory activity in the prefrontal cortex (PFC). Given the essential role of GABA neurotransmission... [ read more ] [ link to publication ]

Cell‐Lineage Tracing in Zebrafish Embryos with an Expanded Genetic Code by Wes Brown
April 27, 2018

From the article: Cell‐lineage tracing is used to study embryo development and stem‐cell differentiation as well as to document tumor cell heterogeneity. Cre recombinase‐mediated cell labeling is the preferred approach;... [ read more ] [ link to publication ]

Fighting Bacterial Pathogens in the Lung: Platelets to the Rescue? by Tolani Olonisakin
March 1, 2018

From the article: Pseudomonas aeruginosa is an extracellular Gram-negative, bacterial, opportunistic pathogen that exploits immunocompromised hosts. Although it is notorious for its ability to persist in the cystic fibrosis... [ read more ] [ link to publication ]