Publications

Trainee: Current

Faculty Member: Corrine Kliment, MD, PhD

Publications:

Sui J, Xiao H, Mbaekwe U, Ting NC, Murday K, Hu Q, Gregory AD, Kapellos TS, Yildirim AÖ, Königshoff M, Zhang Y, Sciurba FC, Das J, Kliment CR. Interpretable machine learning uncovers epithelial transcriptional rewiring and a role for Gelsolin in COPD. JCI Insight. 2024 Oct 1:e180239. doi: 10.1172/jci.insight.180239. Epub ahead of print. PMID: 39352744.

Trainee Name: Jessica Medrano

Trainee: Current

Faculty Member: Philana Ling Lin, MD, MSC

Publications:

Malhotra N, Oh S, Finin P, Medrano J, Andrews J, Goodwin M, Markowitz T, Lack J, Boshoff H, Barry C. Environmental fungi target thiol homeostasis to compete with Mycobacterium tuberculosis. PLoS Biology. 2024 Dec 03. PMID: 39625876.

Medrano JM, Maiello P, Rutledge T, Tomko J, Rodgers MA, Fillmore D, Frye LJ, Janssen C, Klein E, Flynn JL, Lin PL. Characterizing the Spectrum of Latent Mycobacterium tuberculosis in the Cynomolgus Macaque Model: Clinical, Immunologic, and Imaging Features of Evolution. J Infect Dis. 2023 Feb 14;227(4):592-601. doi: 10.1093/infdis/jiac504. PMID: 36611221; PMCID: PMC9927077.

Trainee Name: Amir Mina, PhD

Trainee: Current

Faculty Member: Shyam Visweswaran, MD, PhD

Publications:

Mina AI, Espino JU, Bradley AM, Thirumala PD, Batmanghelich K, Visweswaran S. Detecting Cerebral Ischemia From Electroencephalography During Carotid Endarterectomy Using Machine Learning. AMIA Jt Summits Transl Sci Proc. 2024 May 31;2024:613-622. PMID: 38827046; PMCID: PMC11141851.

Mina AI, Espino JU, Bradley AM, Thirumala P, Batmanghelich K, Visweswaran S. Time-Series Aware Metrics for the Evaluation of Intraoperative Electroencephalography-Based Ischemia Detection. Stud Health Technol Inform. 2024 Jan 25;310:274-278. doi: 10.3233/SHTI230970. PMID: 38269808.

Bata A, Al Qudah A, Algarni S, Al Ta'ani O, Balzer JR, Crammond DJ, Shandal V, Gross BA, Lang MJ, Anetakis KM, Narayanan S, Mina A, Thirumala PD. Diagnostic Accuracy of Somatosensory Evoked Potentials and Electroencephalography During Endovascular Treatment of Unruptured Cerebral Aneurysms. World Neurosurg. 2023 Jun 26:S1878-8750(23)00863-X. doi: 10.1016/j.wneu.2023.06.087. Epub ahead of print. PMID: 37380051.

Fleseriu CM, Sultan I, Brown JA, Mina A, Frenchman J, Crammond DJ, Balzer J, Anetakis KM, Subramaniam K, Shandal V, Navid F, Thirumala PD. Role of Intraoperative Neurophysiological Monitoring in Preventing Stroke After Cardiac Surgery. Ann Thorac Surg. 2023 Sep;116(3):623-629. doi: 10.1016/j.athoracsur.2023.01.004. Epub 2023 Jan 10. PMID: 36634835.

Moehl K, Shandal V, Anetakis K, Paras S, Mina A, Crammond D, Balzer J, Thirumala PD. Predicting transient ischemic attack after carotid endarterectomy: The role of intraoperative neurophysiological monitoring. Clin Neurophysiol. 2022 Sep;141:1-8. doi: 10.1016/j.clinph.2022.06.010. Epub 2022 Jun 24. PMID: 35797873.

Paras S, Mina A, Crammond DJ, Visweswaran S, Anetakis KM, Balzer JR, Shandal V, Thirumala PD. Cardiovascular-related mortality after intraoperative neurophysiologic monitoring changes during carotid endarterectomy. Clin Neurophysiol. 2022 Jul;139:43-48. doi: 10.1016/j.clinph.2022.04.005. Epub 2022 Apr 22. PMID: 35525076.

Melachuri SR, Melachuri MK, Mina A, Anetakis K, Crammond DJ, Balzer JR, Shandal V, Thirumala PD. Optimal "Low" Pedicle Screw Stimulation Threshold to Predict New Postoperative Lower-Extremity Neurologic Deficits During Lumbar Spinal Fusions. World Neurosurg. 2021 Jul;151:e250-e256. doi: 10.1016/j.wneu.2021.04.022. Epub 2021 Apr 16. PMID: 33872842.

Trainee Name: Robert Morrison, PhD

Trainee: Current

Faculty Member: Hassane Zarour, MD

Publications:

Davar D, Morrison RM, Dzutsev AK, Karunamurthy A, Chauvin JM, Amatore F, Deutsch JS, Das Neves RX, Rodrigues RR, McCulloch JA, Wang H, Hartman DJ, Badger JH, Fernandes MR, Bai Y, Sun J, Cole AM, Aggarwal P, Fang JR, Deitrick C, Bao R, Duvvuri U, Sridharan SS, Kim SW, A Choudry H, Holtzman MP, Pingpank JF, O'Toole JP, DeBlasio R, Jin Y, Ding Q, Gao W, Groetsch C, Pagliano O, Rose A, Urban C, Singh J, Divarkar P, Mauro D, Bobilev D, Wooldridge J, Krieg AM, Fury MG, Whiteaker JR, Zhao L, Paulovich AG, Najjar YG, Luke JJ, Kirkwood JM, Taube JM, Park HJ, Trinchieri G, Zarour HM. Neoadjuvant vidutolimod and nivolumab in high-risk resectable melanoma: A prospective phase II trial. Cancer Cell. 2024 Nov 11;42(11):1898-1918.e12. doi: 10.1016/j.ccell.2024.10.007. Epub 2024 Oct 31. PMID: 39486411; PMCID: PMC11560503.

Bai Y, Qin Y, Fan Z, Morrison RM, Nam K, Zarour HM, Koldamova R, Padiath QS, Kim S, Park HJ. scMAPA: Identification of cell-type-specific alternative polyadenylation in complex tissues. Gigascience. 2022 Apr 30;11:giac033. doi: 10.1093/gigascience/giac033. PMID: 35488860; PMCID: PMC9055853.

Pagliano O, Morrison RM, Chauvin JM, Banerjee H, Davar D, Ding Q, Tanegashima T, Gao W, Chakka SR, DeBlasio R, Lowin A, Kara K, Ka M, Zidi B, Amin R, Raphael I, Zhang S, Watkins SC, Sander C, Kirkwood JM, Bosenberg M, Anderson AC, Kuchroo VK, Kane LP, Korman AJ, Rajpal A, West SM, Han M, Bee C, Deng X, Schebye XM, Strop P, Zarour HM. Tim-3 mediates T cell trogocytosis to limit antitumor immunity. J Clin Invest. 2022 May 2;132(9):e152864. doi: 10.1172/JCI152864. PMID: 35316223; PMCID: PMC9057587.

McCulloch JA, Davar D, Rodrigues RR, Badger JH, Fang JR, Cole AM, Balaji AK, Vetizou M, Prescott SM, Fernandes MR, Costa RGF, Yuan W, Salcedo R, Bahadiroglu E, Roy S, DeBlasio RN, Morrison RM, Chauvin JM, Ding Q, Zidi B, Lowin A, Chakka S, Gao W, Pagliano O, Ernst SJ, Rose A, Newman NK, Morgun A, Zarour HM, Trinchieri G, Dzutsev AK. Intestinal microbiota signatures of clinical response and immune-related adverse events in melanoma patients treated with anti-PD-1. Nat Med. 2022 Mar;28(3):545-556. doi: 10.1038/s41591-022-01698-2. Epub 2022 Feb 28. PMID: 35228752; PMCID: PMC10246505.

Davar D, Dzutsev AK, McCulloch JA, Rodrigues RR, Chauvin JM, Morrison RM, Deblasio RN, Menna C, Ding Q, Pagliano O, Zidi B, Zhang S, Badger JH, Vetizou M, Cole AM, Fernandes MR, Prescott S, Costa RGF, Balaji AK, Morgun A, Vujkovic-Cvijin I, Wang H, Borhani AA, Schwartz MB, Dubner HM, Ernst SJ, Rose A, Najjar YG, Belkaid Y, Kirkwood JM, Trinchieri G, Zarour HM. Fecal microbiota transplant overcomes resistance to anti-PD-1 therapy in melanoma patients. Science. 2021 Feb 5;371(6529):595-602. doi: 10.1126/science.abf3363. PMID: 33542131; PMCID: PMC8097968.

Trainee Name: Shruti Nanivadekar

Trainee: Current

Faculty Member: Aryn Gittis, PhD

Publications:

Spix TA, Nanivadekar S, Toong N, Kaplow IM, Isett BR, Goksen Y, Pfenning AR, Gittis AH. Population-specific neuromodulation prolongs therapeutic benefits of deep brain stimulation. Science. 2021 Oct 8;374(6564):201-206. doi: 10.1126/science.abi7852. Epub 2021 Oct 7. PMID: 34618556.

Kariv S, Choi JW, Mirpour K, Gordon AM, Alijanpourotaghsara A, Benam M, Abdalla R, Chilukuri S, Gu JW, Bokil H, Nanivadekar S, Gittis AH, Pouratian N. Pilot Study of Acute Behavioral Effects of Pallidal Burst Stimulation in Parkinson's Disease. Mov Disord. 2024 Jul 15. doi: 10.1002/mds.29928. Epub ahead of print. PMID: 39007445.

Trainee Name: Helena Oft

Trainee: Current

Faculty Member: Dandan Sun, MD, PhD

Publications:

Oft HC, Simon DW, Sun D. New insights into metabolism dysregulation after TBI. J Neuroinflammation. 2024 Jul 29;21(1):184. doi: 10.1186/s12974-024-03177-6. PMID: 39075578; PMCID: PMC11288120.

Bielanin JP, Metwally SAH, Oft HCM, Paruchuri SS, Lin L, Capuk O, Pennock ND, Song S, Sun D. NHE1 Protein in Repetitive Mild TBI-Mediated Neuroinflammation and Neurological Function Impairment. Antioxidants (Basel). 2024 Jul 13;13(7):836. doi: 10.3390/antiox13070836. PMID: 39061904; PMCID: PMC11274226.

Song S, Oft H, Metwally S, Paruchuri S, Bielanin J, Fiesler V, Sneiderman C, Kohanbash G, Sun D. Deletion of Slc9a1 in Cx3cr1⁺ cells stimulated microglial subcluster CREB1 signaling and microglia-oligodendrocyte crosstalk. J Neuroinflammation. 2024 Mar 20;21(1):69. doi: 10.1186/s12974-024-03065-z. PMID: 38509618; PMCID: PMC10953158.

Bhuiyan MIH, Fischer S, Patel SM, Oft H, Zhang T, Foley LM, Zhang J, Hitchens TK, Molyneaux BJ, Deng X, Sun D. Efficacy of novel SPAK inhibitor ZT-1a derivatives (1c, 1d, 1g & 1h) on improving post-stroke neurological outcome and brain lesion in mice. Neurochem Int. 2023 Jan;162:105441. doi: 10.1016/j.neuint.2022.105441. Epub 2022 Nov 11. PMID: 36375633; PMCID: PMC9839627.

Song S, Hasan MN, Yu L, Paruchuri SS, Bielanin JP, Metwally S, Oft HCM, Fischer SG, Fiesler VM, Sen T, Gupta RK, Foley LM, Hitchens TK, Dixon CE, Cambi F, Sen N, Sun D. Microglial-oligodendrocyte interactions in myelination and neurological function recovery after traumatic brain injury. J Neuroinflammation. 2022 Oct 5;19(1):246. doi: 10.1186/s12974-022-02608-6. PMID: 36199097; PMCID: PMC9533529.

Trainee Name: Lola Ortiz-Whittingham

Trainee: Current

Faculty Member: Zongqi Xia, MD, PhD

Publications:

Baumer Y, Singh K, Baez AS, Gutierrez-Huerta CA, Chen L, Igboko M, Turner BS, Yeboah JA, Reger RN, Ortiz-Whittingham LR, Bleck CKE, Mitchell VM, Collins BS, Pirooznia M, Dagur PK, Allan DSJ, Muallem-Schwartz D, Childs RW, Powell-Wiley TM. Social Determinants modulate NK cell activity via obesity, LDL, and DUSP1 signaling. bioRxiv [Preprint]. 2023 Sep 15:2023.09.12.556825. doi: 10.1101/2023.09.12.556825. PMID: 37745366; PMCID: PMC10515802.

Ortiz-Whittingham LR, Zhan L, Ortiz-Chaparro EN, Baumer Y, Zenk S, Lamar M, Powell-Wiley TM. Neighborhood Perceptions Are Associated With Intrinsic Amygdala Activity and Resting-State Connectivity With Salience Network Nodes Among Older Adults. Psychosom Med. 2024 Feb-Mar 01;86(2):116-123. doi: 10.1097/PSY.0000000000001272. Epub 2023 Dec 28. PMID: 38150567; PMCID: PMC10922456.

Trainee Name: Maryanna Owoc MD, PhD

Trainee: Current

Faculty Member: Karl Kandler, PhD , Srivatsun Sadagopan, PhD

Publications:

Reitz, KM, Terhorst, L, Smith, CN, Campwala, IK, Owoc, MS, Downs-Canner, SM, Diego, EJ, Switzer, GE, Rosengart, MR, Myers, SP. Healthcare providers’ perceived support from their organization is associated with lower burnout and anxiety amid the COVID-19 pandemic. Plos One. 2021 Nov 19. PMID: 34797847, PMCID: PMC8604356

Baddour K, Fadel M, Zhao M, Corcoran M, Owoc MS, Thomas TH, Sabik LM, Nilsen ML, Ferris RL, Mady LJ. The cost of cure: Examining objective and subjective financial toxicity in head and neck cancer survivors. Head Neck. 2021 Jul 8. PMID: 34235804

Mady LJ, Lyu L, Owoc MS, Peddada SD, Thomas TH, Sabik LM, Johnson JT, Nilsen ML. Understanding financial toxicity in head and neck cancer survivors. Oral Oncology. 2019 Aug. PMID: 31345389

Trainee Name: Olivia Parks PhD

Trainee: Current

Faculty Member: John Williams, MD

Publications:

Parks OB, Williams JV. Method to Assess Immunosenescent CD8+ T Cells in Respiratory Viral Infections. Methods Mol Biol. 2025;2857:33-43. doi: 10.1007/978-1-0716-4128-6_4. PMID: 39348053.

Antos D, Parks OB, Duray AM, Abraham N, Michel JJ, Kupul S, Westcott R, Alcorn JF. Cell-intrinsic regulation of phagocyte function by interferon lambda during pulmonary viral, bacterial super-infection. PLoS Pathog. 2024 Aug 23;20(8):e1012498. doi: 10.1371/journal.ppat.1012498. PMID: 39178311; PMCID: PMC11376568.

Eddens T, Parks OB, Lou D, Fan L, Sojati J, Ramsey MJ, Schmitt L, Salgado CM, Reyes-Mugica M, Evans A, Zou HM, Oury TD, Byersdorfer C, Chen K, Williams JV. Monocyte Production of C1q Potentiates CD8⁺ T-Cell Function Following Respiratory Viral Infection. Am J Respir Cell Mol Biol. 2024 Sep;71(3):294-306. doi: 10.1165/rcmb.2024-0004OC. PMID: 38696270; PMCID: PMC11376238.

Sojati J, Parks OB, Zhang Y, Walters S, Lan J, Eddens T, Lou D, Fan L, Chen K, Oury TD, Williams JV. IFN-λ drives distinct lung immune landscape changes and antiviral responses in human metapneumovirus infection. mBio. 2024 May 8;15(5):e0055024. doi: 10.1128/mbio.00550-24. Epub 2024 Mar 26. PMID: 38530032; PMCID: PMC11077986.

Eddens T, Parks OB, Zhang Y, Manni ML, Casanova JL, Ogishi M, Williams JV. PD-1 signaling in neonates restrains CD8⁺ T cell function and protects against respiratory viral immunopathology. Mucosal Immunol. 2024 Jun;17(3):476-490. doi: 10.1016/j.mucimm.2023.12.004. Epub 2024 Jan 3. PMID: 38176655; PMCID: PMC11180597.

Parks OB, Antos D, Eddens T, Walters S, Johnson M, Oury TD, Gottschalk RA, Erickson JJ, Williams JV. PD-1 Impairs CD8+ T Cell Granzyme B Production in Aged Mice during Acute Viral Respiratory Infection. Immunohorizons. 2023 Nov 1;7(11):771-787. doi: 10.4049/immunohorizons.2300094. PMID: 38015461; PMCID: PMC10696419.

Parks OB, Eddens T, Sojati J, Lan J, Zhang Y, Oury TD, Ramsey M, Erickson JJ, Byersdorfer CA, Williams JV. Terminally exhausted CD8⁺ T cells contribute to age-dependent severity of respiratory virus infection. Immun Ageing. 2023 Aug 1;20(1):40. doi: 10.1186/s12979-023-00365-5. PMID: 37528458; PMCID: PMC10391960.

Freeman KG, Robotham AC, Parks OB, Abad L, Jacobs-Sera D, Lauer MJ, Podgorski JM, Zhang Y, Williams JV, White SJ, Kelly JF, Hatfull GF, Pope WH. Virion glycosylation influences mycobacteriophage immune recognition. Cell Host Microbe. 2023 Jul 12;31(7):1216-1231.e6. doi: 10.1016/j.chom.2023.05.028. Epub 2023 Jun 16. PMID: 37329881; PMCID: PMC10527164.

Parks OB, Eddens T, Zhang Y, Oury TD, McElroy A, Williams JV. Human Metapneumovirus Reinfection in Aged Mice Recapitulates Increased Disease Severity in Elderly Humans Infected with Human Metapneumovirus. Immunohorizons. 2023 Jun 1;7(6):398-411. doi: 10.4049/immunohorizons.2300026. PMID: 37261717; PMCID: PMC10321313.

Parks OB, Keith M, Squires JH, Venkat VL, Mahmood B. Liver Microabscesses in a Premature Neonate With Eosinophilic Colitis. ACG Case Rep J. 2022 Jul 1;9(7):e00817. doi: 10.14309/crj.0000000000000817. PMID: 35784499; PMCID: PMC9246066.

Trainee Name: Tara Pirnia, PhD

Trainee: Current

Faculty Member: Leila Wehbe, Bonnie Nazbanou

Publications:

Lipski WJ, Alhourani A, Pirnia T, Jones PW, Dastolfo-Hromack C, Helou LB, Crammond DJ, Shaiman S, Dickey MW, Holt LL, Turner RS, Fiez JA, Richardson RM. Subthalamic Nucleus Neurons Differentially Encode Early and Late Aspects of Speech Production. J Neurosci. 2018 Jun 13;38(24):5620-5631. doi: 10.1523/JNEUROSCI.3480-17.2018. Epub 2018 May 22. PMID: 29789378; PMCID: PMC6001034.