Publications

Culley MK, Chan SY. Human Endogenous Retrovirus K and Pulmonary Arterial Hypertension: A New Take on a Retro Idea. Circulation. 136,1936-38 (2017).

Culley MK, and Chan SY. Mitochondrial metabolism in pulmonary hypertension: beyond mountains there are mountains. J Clin Invest. 2018;128(9):3704-15. PMCID: PMC6118596

Cai J, Culley MK, Zhao Y, and Zhao J. The role of ubiquitination and deubiquitination in the regulation of cell junctions. Protein Cell.2018;9(9):754-69.PMCID: PMC6107491

Yu Q, Tai YY, Tang Y, Zhao J, Negi V, Culley MK, et al. BOLA (BolA Family Member 3) Deficiency Controls Endothelial Metabolism and Glycine Homeostasis in Pulmonary Hypertension. Circulation. 2019;139(19):2238-55. PMCID: PMC6519484

Yu Q, Tai YY, Tang Y, Zhao J, Negi V, Culley MK, et al. BOLA (BolA Family Member 3) Deficiency Controls Endothelial Metabolism and Glycine Homeostasis in Pulmonary Hypertension. Circulation.2019;139(19):2238-55.PMCID: PMC6519484

Culley MK, Perk D, and Chan SY. NFU1, Iron-Sulfur Biogenesis, and Pulmonary Arterial Hypertension: A (Metabolic) Shift in our Thinking. Am J Respir Cell Mol Biol.2019. PMCID: PMC6993537

Kumar P, Monin L, Castillo P, Elsegeiny W, Horne W, Eddens T, Vikram A, Good M, Schoenborn AA, Bibby K, Montelaro RC, Metzger DW, Gulati AS, Kolls JK. Intestinal Interleukin-17 Receptor Signaling Mediates Reciprocal Control of the Gut Microbiota and Autoimmune Inflammation. Immunity. 2016 Mar 15;44(3):659-671. doi: 10.1016/j.immuni.2016.02.007. PMID: 26982366; PMCID: PMC4794750.

Castillo P, Kolls JK. IL-10: A Paradigm for Counterregulatory Cytokines. J Immunol. 2016 Sep 1;197(5):1529-30. doi: 10.4049/jimmunol.1601192. PMID: 27543665.

Eddens T, Elsegeiny W, Garcia-Hernadez ML, Castillo P, Trevejo-Nunez G, Serody K, Campfield BT, Khader SA, Chen K, Rangel-Moreno J, Kolls JK. Pneumocystis-Driven Inducible Bronchus-Associated Lymphoid Tissue Formation Requires Th2 and Th17 Immunity. Cell Rep. 2017 Mar 28;18(13):3078-3090. doi: 10.1016/j.celrep.2017.03.016. PMID: 28355561; PMCID: PMC5411079.

Elsegeiny W, Zheng M, Eddens T, Gallo RL, Dai G, Trevejo-Nunez G, Castillo P, Kracinovsky K, Cleveland H, Horne W, Franks J, Pociask D, Pilarski M, Alcorn JF, Chen K, Kolls JK. Murine models of Pneumocystis infection recapitulate human primary immune disorders. JCI Insight. 2018 Jun 21;3(12):e91894. doi: 10.1172/jci.insight.91894. PMID: 29925696; PMCID: PMC6124425.

Trevejo-Nunez G, Elsegeiny W, Aggor FEY, Tweedle JL, Kaplan Z, Gandhi P, Castillo P, Ferguson A, Alcorn JF, Chen K, Kolls JK, Gaffen SL. Interleukin-22 (IL-22) Binding Protein Constrains IL-22 Activity, Host Defense, and Oxidative Phosphorylation Genes during Pneumococcal Pneumonia. Infect Immun. 2019 Oct 18;87(11):e00550-19. doi: 10.1128/IAI.00550-19. PMID: 31451621; PMCID: PMC6803344.

Castillo-Dela Cruz P, Wanek AG, Kumar P, An X, Elsegeiny W, Horne W, Fitch A, Burr AHP, Gopalakrishna KP, Chen K, Methé BA, Canna SW, Hand TW, Kolls JK. Intestinal IL-17R Signaling Constrains IL-18-Driven Liver Inflammation by the Regulation of Microbiome-Derived Products. Cell Rep. 2019 Nov 19;29(8):2270-2283.e7. doi: 10.1016/j.celrep.2019.10.042. PMID: 31747600; PMCID: PMC6886715.

Castillo, P.A.C. & Hand, T.W. A little fiber goes a long way. Immunity. 2018, May; 48(5): 844-846.

Dosunmu-Ogunbi AM, Wood KC, Novelli EM, Straub AC. Decoding the role of SOD2 in sickle cell disease. Blood Advances. 2019 Sep;3(17):2679-2687. DOI: 10.1182/bloodadvances.2019000527.

Dwyer, G.K., Mathews, L.R., Lucas, A., Gonzalez de Peredo, A., Blazar, B.R., Girard, J.P., Shlomchik, W., Poholek, A., Turnquist, H.R. (2021). IL-33 acts as a novel costimulatory agent to generate alloreactive Type 1 T helper cells. J Clin Invest. (In revision)

Bartolacci, J.G., Behun, M., Warunek, J.J.P., Li, T., Sahu, A., Dwyer, G.K., Lucas, A., Ambrosio, F., Turnquist, H.R., and Badylak, S.F. (2021). Matrix-Bound Nanovesicle-associated IL-33 Supports Functional Recovery After Skeletal Muscle Injury by Initiating a Pro-Regenerative Macrophage Phenotypic Transition. Nature Regenerative Medicine. (In revision)

Li, T.*, Zhang, Z.*, Bartolacci, J.G., Dwyer, G.K., Liu, Q., Mathews, L.R., Velayutham, M., Roessing, A.S., Lee, Y.C., Dai, H., Shiva, S., Oberbarnscheidt, M.H., Dziki, J.L., Mullet, S.J., Wendell, S.G., Wilkinson, J.D., Webber, S.A., Wood-Trageser, M., Watkins, S.C., Demetris, A.J., Hussey, G.S., Badylak, S.F., Turnquist, H.R. (2020). Graft IL-33 regulates infiltrating macrophages to protect against chronic rejection. J Clin Invest. *Co-first authors

Liu, Q.*, Dwyer, G.K.*, Zhao, Y., Huihua L., Mathews, L.R., Chakka, A.B., Chandran, U.R., Thomson, A.W., Fan, M., Billiar, T.R., and Turnquist, H.R. (2019). IL-33-mediated IL-13 secretion by ST2+ Treg controls inflammation after lung injury. JCI Insight. *Co-first authors, equally contributed to this work.

Gale J, Aizenman E. The physiological and pathophysiological roles of copper in the nervous system. Eur J Neurosci. 2024 Jul;60(1):3505-3543. doi: 10.1111/ejn.16370. Epub 2024 May 15. PMID: 38747014.

Gale, J. R., Hartnett-Scott, K., Ross, M. M., Rosenberg, P. A., & Aizenman, E. (2023). Copper induces neuron-sparing, ferredoxin 1-independent astrocyte toxicity mediated by oxidative stress. Journal of neurochemistry, 10.1111/jnc.15961. Advance online publication. https://doi.org/10.1111/jnc.15961

Hernandez-Espinosa, D. R., Gale, J. R., Scrabis, M. G., & Aizenman, E. (2023). Microglial reprogramming by Hv1 antagonism protects neurons from inflammatory and glutamate toxicity. Journal of neurochemistry, 165(1), 29–54. https://doi.org/10.1111/jnc.15760

Krall, R., Gale, J. R., Ross, M. M., Tzounopoulos, T., & Aizenman, E. (2022). Intracellular zinc signaling influences NMDA receptor function by enhancing the interaction of ZnT1 with GluN2A. Neuroscience letters, 790, 136896. https://doi.org/10.1016/j.neulet.2022.136896

Gleixner, A. M., Verdone, B. M., Otte, C. G., Anderson, E. N., Ramesh, N., Shapiro, O. R., Gale, J. R., Mauna, J. C., Mann, J. R., Copley, K. E., Daley, E. L., Ortega, J. A., Cicardi, M. E., Kiskinis, E., Kofler, J., Pandey, U. B., Trotti, D., & Donnelly, C. J. (2022). NUP62 localizes to ALS/FTLD pathological assemblies and contributes to TDP-43 insolubility. Nature communications, 13(1), 3380. https://doi.org/10.1038/s41467-022-31098-6

Gale, J. R., Gedeon, J. Y., Donnelly, C. J., & Gold, M. S. (2022). Local translation in primary afferents and its contribution to pain. Pain, 163(12), 2302–2314. https://doi.org/10.1097/j.pain.0000000000002658

Gale, J. R., Kosobucki, G. J., Hartnett-Scott, K. A., & Aizenman, E. (2021). Imprecision in Precision Medicine: Differential Response of a Disease-Linked GluN2A Mutant to NMDA Channel Blockers. Frontiers in pharmacology, 12, 773455. https://doi.org/10.3389/fphar.2021.773455

Liu, H. Y., Gale, J. R., Reynolds, I. J., Weiss, J. H., & Aizenman, E. (2021). The Multifaceted Roles of Zinc in Neuronal Mitochondrial Dysfunction. Biomedicines, 9(5), 489. https://doi.org/10.3390/biomedicines9050489

Simmons, C., Granovetter, M.C., Robert, S., Liu, T. T., Patterson, C., & Behrmann, M. (2024). Holistic processing and face expertise after pediatric resection of occipitotemporal cortex. Neuropsychologia, 194, 108789. https://doi.org/10.1016/j.neuropsychologia.2024.108789

Granovetter MC, Robert S, Ettensohn L, Behrmann M. With childhood hemispherectomy, one hemisphere can support-but is suboptimal for-word and face recognition. Proc Natl Acad Sci U S A. 2022 Nov;119(44):e2212936119. doi: 10.1073/pnas.2212936119. Epub 2022 Oct 25. PMID: 36282918; PMCID: PMC9636967.

Macedo B, Christophers B, Barrere-Cain R, Albrecht YS, Granovetter MC, Kumar R, Daye D, Bhoj E, Brass L, Rodrigues JA. The Virtual Summer Research Program: supporting future physician-scientists from underrepresented backgrounds. J Clin Transl Sci. 2022 Aug 22;6(1):e120. doi: 10.1017/cts.2022.447. PMID: 36285020; PMCID: PMC9549583.

Granovetter MC, Burlingham CS, Blauch NM, Minshew NJ, Heeger DJ, Behrmann M. Uncharacteristic Task-Evoked Pupillary Responses Implicate Atypical Locus Ceruleus Activity in Autism. J Neurosci. 2020 May 6;40(19):3815-3826. doi: 10.1523/JNEUROSCI.2680-19.2020. Epub 2020 Apr 6. PMID: 32253362; PMCID: PMC7204084.

Maallo AMS, Granovetter MC, Freud E, Kastner S, Pinsk MA, Patterson C, Behrmann M. Large-scale resculpting of cortical circuits in children after surgical resection. Sci Rep. 2020 Dec 9;10(1):21589. doi: 10.1038/s41598-020-78394-z. PMID: 33299002; PMCID: PMC7725819.

Williams Avram SK, Lee HJ, Fastman J, Cymerblit-Sabba A, Smith A, Vincent M, Song J, Granovetter MC, Lee SH, Cilz NI, Stackmann M, Chaturvedi R, Young WS. NMDA Receptor in Vasopressin 1b Neurons Is Not Required for Short-Term Social Memory, Object Memory or Aggression. Front Behav Neurosci. 2019 Nov 8;13:218. doi: 10.3389/fnbeh.2019.00218. PMID: 31787886; PMCID: PMC6856057.

Harvey LD, Chan SY. Evolving systems biology approaches to understanding non-coding RNAs in pulmonary hypertension. J Physiol. 2018. PubMed PMID: 30113078.

Harvey LD, Chan SY. YAPping About Glutaminolysis in Hepatic Fibrosis. Gastroenterology. 2018;154(5):1231-1233.

Ranchoux B, Harvey LD, Ayon RJ, et al. Endothelial dysfunction in pulmonary arterial hypertension: an evolving landscape (2017 Grover Conference Series). Pulm Circ. 2018;8(1):2045893217752912. PubMed PMID: 29283043; PubMed Central PMCID: PMC5798691.

Harvey LD, Chan SY. Emerging Metabolic Therapies in Pulmonary Arterial Hypertension. J Clin Med. 2017;6(4). PubMed PMID: 28375184; PubMed Central PMCID: N/A.

Begum G*, Harvey L*, Dixon CE, Sun D. ER stress and effects of DHA as an ER stress inhibitor. Translational Stroke Research. 2013;4(6):635-42. Epub 2013/12/11. doi: 10.1007/s12975-013-0282-1. PubMed PMID: 24323417; PubMed Central PMCID: PMC3864671. *denotes co-first authorship.

Harvey L, Yin Y, Attarwala IY, Begum G, Deng J, Yan HQ, Dixon CE, Sun D. Administration of DHA reduces ER stress-associated inflammation and alters microglial or macrophage activation in traumatic brain injury. ASN Neuro. 2015;7(6). PubMed PMID: 26685193; PubMed Central PMCID: PMC4710127.

Zonouzi M, Scafidi J, Li P, McEllin B, Edwards J, Dupree JL, Harvey L, Sun D, Hubner CA, Cull-Candy SG, Farrant M, Gallo V. GABAergic regulation of cerebellar NG2 cell development is altered in perinatal white matter injury. Nature Neuroscience. 2015;18(5):674-82. Epub 2015/03/31. doi: 10.1038/nn.3990. PubMed PMID: 25821912; PubMed Central PMCID: PMC4459267.

Santos-Lopez A, Fritz MJ, Lombardo JB, Burr AHP, Heinrich VA, Marshall CW, Cooper VS. Evolved resistance to a novel cationic peptide antibiotic requires high mutation supply. Evol Med Public Health. 2022 May 30;10(1):266-276. doi: 10.1093/emph/eoac022. PMID: 35712084; PMCID: PMC9198447.

Manni ML, Heinrich VA, Buchan GJ, O'Brien JP, Uvalle C, Cechova V, Koudelka A, Ukani D, Rawas-Qalaji M, Oury TD, Hart R, Ellgass M, Mullett SJ, Fajt ML, Wenzel SE, Holguin F, Freeman BA, Wendell SG. Nitroalkene fatty acids modulate bile acid metabolism and lung function in obese asthma. Sci Rep. 2021 Sep 7;11(1):17788. doi: 10.1038/s41598-021-96471-9. PMID: 34493738; PMCID: PMC8423735.

Nguyen E, Smith KM, Cramer N, Holland RA, Bleimeister IH, Flores-Felix K, Silberberg H, Keller A, Le Pichon CE, Ross SE. Medullary kappa-opioid receptor neurons inhibit pain and itch through a descending circuit. Brain. 2022 Jul 29;145(7):2586-2601. doi: 10.1093/brain/awac189. PMID: 35598161.

Holland RA, Ross SE. Beyond lidocaine: selective voltage-gated sodium channel blockade for vaginal pain. Pain. 2021 Jan;162(1):1-3. doi: 10.1097/j.pain.0000000000002037. PMID: 32773604.

Johnson A, Cooper GF, Visweswaran S. Patient-specific modeling with personalized decision paths. In: Virtual AMIA Fall Symposium. November 2020.