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Joshua Wesalo MD, PhD

    Education & Training

  • University of Pittsburgh, MD, 2023
  • University of Pittsburgh, PhD, 2021
  • Franklin & Marshall College, BA, 2013
Representative Publications

Brown W, Wesalo J, Tsang M, Deiters A. Engineering Small Molecule Switches of Protein Function in Zebrafish Embryos. J Am Chem Soc. 2023 Feb 1;145(4):2395-2403. doi: 10.1021/jacs.2c11366. Epub 2023 Jan 20. PMID: 36662675.

Brown, W., Wesalo, J., Samanta, S., Luo, J., Caldwell, S. E., Tsang, M., & Deiters, A. (2023). Genetically Encoded Aminocoumarin Lysine for Optical Control of Protein–Nucleotide Interactions in Zebrafish Embryos. ACS Chemical Biology.

Joest, E. F.; Winter, C.; Wesalo, J. S.; Deiters, A.; Tampé, R. “Efficient Amber Suppression by Ribosomal Skipping for In Situ Synthesis of Photoconditional Nanobodies.” Angewandte Chemie.

Joest, E. F.; Winter, C.; Wesalo, J. S.; Deiters, A.; Tampé, R. “Light-guided intrabodies for on-demand in situ target recognition in human cells.” Chem. Sci. 2021, 12, 5787–5795.

Zhou, W.; Wesalo, J. S.; Liu, J.; Deiters, A. “Genetic code expansion in mammalian cells: A plasmid system comparison.” Bioorg. Med. Chem. 2020, 28, 115772.

Wesalo, J. S.; Deiters, A. “Fast phosphine-activated control of protein function using unnatural lysine analogues.” Methods Enzymol. 2020, 638, 191–217.

Wesalo, J. S.; Luo, J.; Morihiro, K.; Liu, J.; Deiters, A. “Phosphine-Activated Lysine Analogues for Fast Chemical Control of Protein Subcellular Localization and Protein SUMOylation.” ChemBioChem 2020, 21, 141–148

Career Advisor
Donald DeFranco, PhD
Thesis Advisor
Alex Deiters, PhD
Dissertation Title

Optical and small-molecule control of protein and nucleic acid function

Graduate Year
Training Start Year