Jack Drda

My research interest is immunometabolism, with an emphasis on hepatic cholesterol biosynthesis. I study metabolic dysfunction-associated steatohepatitis (MASH), cholestasis, and primary sclerosing cholangitis. I also research isoprenoid metabolites in rare autoinflammatory disorders, such as mevalonate kinase deficiency (MKD) and the newly described phosphomevalonte kinase deficiency (PMVK). By investigating inborn errors of cholesterol biosynthesis, I seek to understand how these metabolic pathways become disordered in other diseases. I have research experience in nuclear receptors (FXR, LXR, & PXR), G protein-coupled receptors, gastrointestinal cancers, nanoparticle precision medicine, and clinical trial design.