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Ansen Burr MD, PhD

    Education & Training

  • University of Pittsburgh, MD, 2023
  • University of Pittsburgh, PhD, 2022
  • University of Oregon, BS, 2015
Representative Publications

Ansen H.P. Burr, Junyi Ji, Kadir Ozler, Onur Eskiocak, Brian Yueh, Ashley Menk, Ana Costa, Natalie Rittenhouse, Chris Marshall, Pailin Chiaranunt, Lauren Mullinax, Abigail Overacre-Delgoffe, Vaugh Cooper, Amanda Poholek, Greg Delgoffe, Semir Beyaz, Timothy Hand. “Dietary sugar alters colonocyte pyruvate metabolism and impairs the early proliferative response to damage.” Cell. Mol. Gastroenterol. Hepatol. May 10, 2023, DOI:

Chelseá Johnson-Hence, Kathyayini Gopalakrishna, Kara Coffey, Ansen H.P. Burr, Syed Rahman, Yelissa Sosa, Justin Tometich, Jishnu Das, Timothy W. Hand. “Stability and heterogeneity in the anti-microbiota repertoire of human milk-derived Immunoglobulin A.” J Exp Med (2023) 220 (8): e20220839. DOI:

Alfonso Santos-Lopez, Melissa J Fritz, Jeffrey B Lombardo, Ansen H.P. Burr, Victoria A Heinrich, Christopher W Marshall, Vaughn S Cooper, “Evolved resistance to a novel cationic peptide antibiotic requires high mutation supply”, Evolution, Medicine, and Public Health, Volume 10, Issue 1, 2022, Pages 266–276, DOI:

Overacre-Delgoffe A.E., Cillo A.R., Bumgarner H.J., Burr A.H.P., Tometich J.T., Bhattacharjee A., Bruno T.C., Vignali D.A.A. and T.W. Hand. Microbiome-specific T follicular helper cells drive tertiary lymphoid structures and anti-tumor immunity against colorectal cancer 2021. Immunity. 2021 Dec 14;54(12):2812-2824.e4. doi: 10.1016/j.immuni.2021.11.003.

Van Der Kraak L.A., Schneider C., Dang V., Burr A.H.P., Weiss E.S., Hand T.W. and S.W. Canna Genetic and commensal induction of Interleukin-18 drive intestinal epithelial MHC class II via Interferon-g. Mucosal Immunology. 2021 Jun 8.  doi: 10.1038/s41385-021-00419-1

Bhattacharjee A., Burr A.H.P., Overacre-Delgoffe A.E., Tometich J.T., Yang D., Huckestein B.R., Linehan J.L., Spencer S.P., Hall J.A., Harrison O.J., Fonseca D.M., Norton, E.B., Belkaid Y. and T.W. Hand. Environmental Enteric Dysfunction induces intestinal regulatory T cells that inhibit local CD4+ T cell responses and impair the efficacy of oral vaccines. Immunity. 2021 Aug 10;54(8):1745-1757 PMID: 34348118

Gopalakrishna KP, Macadangdang BR, Rogers MB, Tometich JT, Firek BA, Baker R, Ji J, Burr AHP, Ma C, Good M, Morowitz MJ, Hand TW. Maternal IgA protects against the development of necrotizing enterocolitis in preterm infants. Nat Med. 2019 Jul;25(7):1110-1115. doi: 10.1038/s41591-019-0480-9. Epub 2019 Jun 17. PMID: 31209335

Castillo-Dela Cruz P, Wanek AG, Kumar P, An X, Elsegeiny W, Horne W, Fitch A, Burr AHP, Gopalakrishna KP, Chen K, Methé BA, Canna SW, Hand TW, Kolls JK. Intestinal IL-17R Signaling Constrains IL-18-Driven Liver Inflammation by the Regulation of Microbiome-Derived Products. Cell Rep. 2019 Nov 19;29(8):2270-2283.e7. doi: 10.1016/j.celrep.2019.10.042. PMID: 31747600; PMCID: PMC6886715.

Burr AHP, Bhattacharjee A, Hand TW. Nutritional Modulation of the Microbiome and Immune Response. J Immunol. 2020 Sep 15;205(6):1479-1487. doi: 10.4049/jimmunol.2000419. PMID: 32900885; PMCID: PMC7490768

Student Year
Career Advisor
Lisa Borghesi, PhD
Thesis Advisor
Timothy Hand, Ph.D.
Microbiology and Immunology
Dissertation Title

Excess dietary sugar directly alters epithelial metabolism and macrophage polarization resulting in lethal colitis

Graduate Year
Training Start Year