The Pandey laboratory is to elucidate the molecular mechanisms of amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, and other related motor neurons diseases. Recently, several RNA-binding proteins have been found to be mutated in both sporadic and familial forms of ALS. Disease causing mutations in these RNA binding proteins suggest that underlying defects in RNA metabolism might play an important role in causing motor neuron degeneration in ALS. The Pandey lab is looking for genetic and small molecule modifiers of ALS in fly and mammalian neuronal models. We expect that these modifiers will not only allow us to understand molecular basis of ALS but also help in developing therapeutic interventions for ALS.
*Currently accepting graduate students