Sebastian Hymson

My research focuses on advancing adoptive T cell therapies for cancer by addressing the mechanisms of dysfunction that limit their efficacy in solid tumors, including inhibitory receptor signaling, exhaustion, and impaired metabolic fitness. I am particularly interested in how these pathways influence T cell persistence and functionality, and in developing strategies to overcome them. By combining cellular engineering, functional assays, and tumor models, I aim to translate mechanistic insights into more durable and clinically effective immunotherapies. My work draws on approaches such as CRISPR-based gene editing, CAR-T engineering, single-cell multi-omics, and in vitro and in vivo tumor modeling.