Dr. Gottschalk's laboratory uses quantitative approaches to understand healthy versus aberrant regulation of inflammation with major projects including (1) computational modeling of signaling-to-transcription in macrophages, (2) interrogating tissue-specific macrophage signaling, and (3) dissecting molecular determinants of monocyte and macrophage inflammatory function. The lab uses experimental approaches, together with both data-driven and mechanistic modeling to integrate transcription factor activity, phosphorylation, and transcriptomic data to explore signaling mechanisms that shape stimulus-specific macrophage function. These efforts will yield insights into dysregulation of signaling and inflammation, while informing therapeutic strategies.
*Currently accepting graduate students