The Steinhauser laboratory is broadly interested in how metabolism is altered by and contributes to disease. Within this context, the lab is focused in three inter-related areas: (1) how systemic metabolic function is modulated by local cellular and molecular derangements in adipose tissue arising during development, aging, or in contexts of energy imbalance. (2) Development of novel stable isotope- based methods to study metabolism. This includes a new quantitative imaging platform called multi- isotope imaging mass spectrometry (MIMS). We have established MIMS as a powerful tool for interrogation of cell turnover and metabolism, in situ, at sub-organelle resolution with studies in model organisms and more recently with first-in-human studies. (3) Defining the molecular and metabolic responses to physiological stressors of relevance to aging biology that drive resiliency.
*Currently accepting graduate students