Publications

Trainee Name: Edgar Aranda-Michel, PhD
Trainee: Current
Faculty Member: Dennis Trumble, PhD
Publications:

E. Aranda-Michel et al., "Miniaturized Robotic End-Effector With Piezoelectric Actuation and Fiber Optic Sensing for Minimally Invasive Cardiac Procedures," in IEEE Sensors Journal, vol. 18, no. 12, pp. 4961-4968, 15 June15, 2018, doi: 10.1109/JSEN.2018.2828940.

Aranda-Michel E, Waldman LK, Trumble DR. Left ventricular simulation of cardiac compression: Hemodynamics and regional mechanics. PLoS One. 2019 Oct 31;14(10):e0224475. doi: 10.1371/journal.pone.0224475. PMID: 31671155; PMCID: PMC6822737.

Han J, Kubala M, Aranda-Michel E, Trumble DR. Ventricle-specific epicardial pressures as a means to optimize direct cardiac compression for circulatory support: A pilot study. PLoS One. 2019 Jul 5;14(7):e0219162. doi: 10.1371/journal.pone.0219162. PMID: 31276569; PMCID: PMC6611657.

Aranda-Michel E, Bianco V, Kilic A, Gleason TG, Navid F, Sultan I. Mortality and Readmissions After On-Pump Versus Off-Pump Redo Coronary Artery Bypass Surgery. Cardiovasc Revasc Med. 2020 Jul;21(7):821-825. doi: 10.1016/j.carrev.2019.12.008. Epub 2019 Dec 5. PMID: 31836478.

Bianco, V, Aranda‐Michel, E, Sultan, I, et al. Inconsistent correlation between procedural volume and publicly reported outcomes in adult cardiac operations. J Card Surg. 2019; 34: 1194‐ 1203. https://doi.org/10.1111/jocs.14218

Aranda-Michel E, Yousef S, Sultan I, Kilic A. Septic coronary embolism in a deceptive case of presumed isolated tricuspid valve endocarditis. J Card Surg. 2019 Oct;34(10):1130-1132. doi: 10.1111/jocs.14198. Epub 2019 Aug 2. PMID: 31374581.

Aranda-Michel E, Bianco V, Sultan I, Gleason TG, Navid F, Kilic A. Predictors of increased costs following index adult cardiac operations: Insights from a statewide publicly reported registry. J Card Surg. 2019 Aug;34(8):708-713. doi: 10.1111/jocs.14117. Epub 2019 Jul 3. PMID: 31269297.

Aranda-Michel E, Bianco V, Kilic A, Gleason TG, Sultan I. Endovascular management of spontaneous rupture of the left subclavian artery. J Card Surg. 2019 Jul;34(7):645-646. doi: 10.1111/jocs.14091. Epub 2019 Jun 18. PMID: 31212383.

Aranda-Michel E, Kilic A, Gleason TG, Bianco V, Sultan I. Diagnostic dilemma in prosthetic valve endocarditis: Computed tomography to the rescue. J Card Surg. 2019 Apr;34(4):208-210. doi: 10.1111/jocs.14001. Epub 2019 Feb 25. PMID: 30803027.

Aranda-Michel E, Kilic A, Bianco V, Gleason TG, Sultan I. Aortitis Masquerading as Intramural Hematoma of the Ascending Aorta. Ann Thorac Surg. 2019 May;107(5):e353. doi: 10.1016/j.athoracsur.2018.12.049. Epub 2019 Jan 28. PMID: 30703366.

Han J, Aranda-Michel E, Trumble DR. Muscle-Powered Counterpulsation for Untethered, Non-Blood-Contacting Cardiac Support: A Path to Destination Therapy. IEEE Trans Biomed Eng. 2020 Nov;67(11):3035-3047. doi: 10.1109/TBME.2020.2974826. Epub 2020 Feb 18. PMID: 32086191; PMCID: PMC7587079.

Daniel Shiwarski*, Joshua Tashman*, Alkiviadis Tsamis, Jacqueline Bliley, Malachi Blundon, Edgar Aranda-Michel, Quentin Jallerat, John Szymanski, Brooke McCartney, and Adam Feinberg. Fibronectin-Based Nanomechanical Biosensors to Map 3D Surface Strains in Live Cells and Tissues. Nature Communications. Oct 2020.

Edgar Aranda-Michel, Valentino Bianco, Keith Dufendach, Arman Kilic, Andreas Habertheuer, Rishab Humar, Forozan Navid,Yisi Wang, and Ibrahim Sultan. Mid-term outcomes of subcoronary stentless porcine valve versus stented aortic valve replacement. Journal of Cardiac Surgery. 2020

Seese L, Aranda-Michel E, Sultan I, Morell VO, Mathier MA, Mulukutla SR, Saba S, Dueweke EJ, Levenson JE, Kilic A. Programmatic Responses to the Coronavirus Pandemic: A Survey of 502 Cardiac Surgeons. Ann Thorac Surg. 2020 Sep;110(3):761-763. doi: 10.1016/j.athoracsur.2020.04.014. Epub 2020 Apr 28. PMID: 32360389; PMCID: PMC7187822.

Aranda-Michel E, Bianco V, Kilic A, Gleason TG, Sultan I. Acute type A aortic dissection with complete intimal intussusception into the descending aorta. J Card Surg. 2020 Jul;35(7):1626-1627. doi: 10.1111/jocs.14599. Epub 2020 May 3. PMID: 32362006.

L. Seese, E. Aranda-Michel, L. Huckaby, M. Keebler, G. Hickey, M. Mathier, I. Sultan, T. Gleason, A. Kilic. Development and Validation of a Risk Score to Predict One-Year Mortality after Bridge to Heart Transplantation with Contemporary Durable Left Ventricular Assist Devices. The Journal of Heart and Lung Transplantation. 2020.

Trainee Name: Wesley Brown
Trainee: Current
Faculty Member: Alex Deiters, PhD
Publications:

Cell Lineage Tracing in Zebrafish Embryos with an Expanded Genetic Code Brown, W.; Liu, J.; Tsang, M.; Deiters, A. ChemBioChem 2018, 19, 1244-1249. Highlighted as a Very Important Paper by ChemBioChem.

Light-Activation of Cre Recombinase in Zebrafish Embryos through Genetic Code Expansion, Brown, W.; Deiters, A. Methods Enzym. 2019, 624, 265-281.

Zhou W, Brown W, Bardhan A, Delaney M, Ilk AS, Rauen RR, Kahn SI, Tsang M, Deiters A. Spatiotemporal Control of CRISPR/Cas9 Function in Cells and Zebrafish using Light-Activated Guide RNA. Angew Chem Int Ed Engl. 2020 Jun 2;59(23):8998-9003. doi: 10.1002/anie.201914575. Epub 2020 Apr 6. PMID: 32160370; PMCID: PMC7250724.

Brown W, Liu J, Deiters A. Genetic Code Expansion in Animals. ACS Chem Biol. 2018;13(9):2375-86. Epub 2018/08/21. doi: 10.1021/acschembio.8b00520. PubMed PMID: 30125487; PMCID: PMC7026698.

Brown W, Zhou W, Deiters A. Regulating CRISPR/Cas9 Function through Conditional Guide RNA Control. Chembiochem. 2021;22(1):63-72. Epub 2020/08/25. doi: 10.1002/cbic.202000423. PubMed PMID: 32833316.

Trainee Name: Ansen Burr
Trainee: Current
Faculty Member: Timothy Hand, Ph.D.
Publications:

Overacre-Delgoffe A.E., Cillo A.R., Bumgarner H.J., Burr A.H.P., Tometich J.T., Bhattacharjee A., Bruno T.C., Vignali D.A.A. and T.W. Hand. Microbiome-specific T follicular helper cells drive tertiary lymphoid structures and anti-tumor immunity against colorectal cancer 2021. Immunity. 2021 Dec 14;54(12):2812-2824.e4. doi: 10.1016/j.immuni.2021.11.003.

Van Der Kraak L.A., Schneider C., Dang V., Burr A.H.P., Weiss E.S., Hand T.W. and S.W. Canna Genetic and commensal induction of Interleukin-18 drive intestinal epithelial MHC class II via Interferon-g. Mucosal Immunology. 2021 Jun 8.  doi: 10.1038/s41385-021-00419-1

Bhattacharjee A., Burr A.H.P., Overacre-Delgoffe A.E., Tometich J.T., Yang D., Huckestein B.R., Linehan J.L., Spencer S.P., Hall J.A., Harrison O.J., Fonseca D.M., Norton, E.B., Belkaid Y. and T.W. Hand. Environmental Enteric Dysfunction induces intestinal regulatory T cells that inhibit local CD4+ T cell responses and impair the efficacy of oral vaccines. Immunity. 2021 Aug 10;54(8):1745-1757 PMID: 34348118

Gopalakrishna KP, Macadangdang BR, Rogers MB, Tometich JT, Firek BA, Baker R, Ji J, Burr AHP, Ma C, Good M, Morowitz MJ, Hand TW. Maternal IgA protects against the development of necrotizing enterocolitis in preterm infants. Nat Med. 2019 Jul;25(7):1110-1115. doi: 10.1038/s41591-019-0480-9. Epub 2019 Jun 17. PMID: 31209335

Castillo-Dela Cruz P, Wanek AG, Kumar P, An X, Elsegeiny W, Horne W, Fitch A, Burr AHP, Gopalakrishna KP, Chen K, Methé BA, Canna SW, Hand TW, Kolls JK. Intestinal IL-17R Signaling Constrains IL-18-Driven Liver Inflammation by the Regulation of Microbiome-Derived Products. Cell Rep. 2019 Nov 19;29(8):2270-2283.e7. doi: 10.1016/j.celrep.2019.10.042. PMID: 31747600; PMCID: PMC6886715.

Burr AHP, Bhattacharjee A, Hand TW. Nutritional Modulation of the Microbiome and Immune Response. J Immunol. 2020 Sep 15;205(6):1479-1487. doi: 10.4049/jimmunol.2000419. PMID: 32900885; PMCID: PMC7490768

Trainee Name: Alison Butler, PhD
Trainee: Current
Faculty Member: Gretchen Chapman, PhD
Publications:

Butler A, Chapman GB. Don't Throw Your Heart Away: Increased Transparency of Donor Utilization Practices in Transplant Center Report Cards Alters How Center Performance Is Evaluated. Med Decis Making. 2022 Apr;42(3):341-351. doi: 10.1177/0272989X211038941. Epub 2021 Oct 4. PMID: 34605713.

Godown J, Butler A, Lebovitz DJ, Chapman G. Predictors of Deceased Organ Donation in the Pediatric Population. Pediatrics. 2021 Jun;147(6):e2020009506. doi: 10.1542/peds.2020-009506. Epub 2021 May 7. PMID: 33963074;.

Butler A, Chapman G, Johnson JN, Amodeo A, Böhmer J, Camino M, Davies RR, Dipchand AI, Godown J, Miera O, Pérez-Blanco A, Rosenthal DN, Zangwill S, Kirk R. Behavioral economics-A framework for donor organ decision-making in pediatric heart transplantation. Pediatr Transplant. 2020 May;24(3):e13655. doi: 10.1111/petr.13655. Epub 2020 Jan 27. PMID: 31985140.

Godown J, Schumacher KR, Butler A, Chapman G, Dipchand AI, Kaslow WW, Bearl DW, Kirk R. Patients and their family members prioritize post-transplant survival over waitlist survival when considering donor hearts for transplantation. Pediatr Transplant. 2020;24(2):e13589. Epub 2019/09/29. doi: 10.1111/petr.13589. PubMed PMID: 31562687    

Godown J, Schumacher KR, Butler A, Chapman G, Dipchand AI, Kaslow WW, Bearl DW, Kirk R. Patients and their family members prioritize post-transplant survival over waitlist survival when considering donor hearts for transplantation. Pediatr Transplant. 2020 Mar;24(2):e13589. doi: 10.1111/petr.13589. Epub 2019 Sep 27. PMID: 31562687.

Kirk R, Dipchand AI, Davies RR, Miera O, Chapman G, Conway J, Denfield S, Gossett JG, Johnson J, McCulloch M, Schweiger M, Zimpfer D, Ablonczy L, Adachi I, Albert D, Alexander P, Amdani S, Amodeo A, Azeka E, Ballweg J, Beasley G, Böhmer J, Butler A, Camino M, Castro J, Chen S, Chrisant M, Christen U, Danziger-Isakov L, Das B, Everitt M, Feingold B, Fenton M, Garcia-Guereta L, Godown J, Gupta D, Irving C, Joong A, Kemna M, Khulbey SK, Kindel S, Knecht K, Lal AK, Lin K, Lord K, Möller T, Nandi D, Niesse O, Peng DM, Pérez-Blanco A, Punnoose A, Reinhardt Z, Rosenthal D, Scales A, Scheel J, Shih R, Smith J, Smits J, Thul J, Weintraub R, Zangwill S, Zuckerman WA. ISHLT consensus statement on donor organ acceptability and management in pediatric heart transplantation. J Heart Lung Transplant. 2020 Apr;39(4):331-341. doi: 10.1016/j.healun.2020.01.1345. Epub 2020 Jan 31. PMID: 32088108.

Trainee Name: Neil Carleton
Trainee: Current
Faculty Member: Adrian Lee, PhD
Publications:

Carleton N, Nasrazadani A, Gade K, Beriwal S, Barry PN, Brufsky AM, Bhargava R, Berg WA, Zuley ML, Marroquin OC, Thull DL, Mai PL, Diego EJ, Lotze MT, Oesterreich S, McAuliffe PF, Lee AV. Personalizing Therapy for Early-Stage ER+ Breast Cancer in Older Women. The Lancet Healthy Longevity. 2021 Nov 9. In Press.
 
Carleton N, Zou J, Fang Y, Koscumb SE, Shah OS, Chen F, Beriwal S, Diego EJ, Brufsky AM, Oesterreich S, Shapiro SD, Ferris R, Emens LA, Tseng G, Marroquin OC, Lee AV, McAuliffe PF. Outcomes After Sentinel Lymph Node Biopsy and Radiotherapy in Older Women With Early-Stage, Estrogen Receptor-Positive Breast Cancer. JAMA Netw Open. 2021 Apr 1;4(4):e216322. doi: 10.1001/jamanetworkopen.2021.6322. PubMed PMID: 33856473; PubMed Central PMCID: PMC8050744.
 
Lee JL, Ekambaram P, Carleton NM, Hu D, Klei LR, Cai Z, Myers MI, Hubel NE, Covic L, Agnihotri S, Krappmann D, Bornancin F, Lee AV, Oesterreich S, McAllister-Lucas L, Lucas PC. MALT1 is a Targetable Driver of Epithelial-to-Mesenchymal Transition in Claudin-low, Triple-Negative Breast Cancer. Mol Cancer Res. 2021 Nov 9;. doi: 10.1158/1541-7786.MCR-21-0208. [Epub ahead of print] PubMed PMID: 34753803.
 
Chen F, Ding K, Priedigkeit N, Elangovan A, Levine KM, Carleton N, Savariau L, Atkinson JM, Oesterreich S, Lee AV. Single-Cell Transcriptomic Heterogeneity in Invasive Ductal and Lobular Breast Cancer Cells. Cancer Res. 2021 Jan 15;81(2):268-281. doi: 10.1158/0008-5472.CAN-20-0696. Epub 2020 Nov 4. PubMed PMID: 33148662; PubMed Central PMCID: PMC7856056.
 
Ghosh-Choudhary S, Carleton N, Flynn JL, Kliment CR. Strategies for Achieving Gender Equity and Work-Life Integration in Physician-Scientist Training. Acad Med. 2021 Jul 20;. doi: 10.1097/ACM.0000000000004246. [Epub ahead of print] PubMed PMID: 34292189.
 

 

Trainee Name: Brittany Chamberlain
Trainee: Current
Faculty Member: Susanne Ahmari, MD, PhD
Publications:

Chamberlain B.L., Ahmari S.E. (2021) Animal Models for OCD Research. In: Fineberg N.A., Robbins T.W. (eds) The Neurobiology and Treatment of OCD: Accelerating Progress. Current Topics in Behavioral Neurosciences, vol 49. Springer, Cham. https://doi.org/10.1007/7854_2020_196

Piantadosi SC, McClain LL, Klei L, Wang J, Chamberlain BL, Springer SA, Lewis DA, Devlin B, Ahmari SE. Transcriptome alterations are enriched for synapse-associated genes in the striatum of subjects with obsessive-compulsive disorder. Transl Psychiatry. 2021 Mar 15;11(1):171. doi: 10.1038/s41398-021-01290-1. PMID: 33723209; PMCID: PMC7961029.

Piantadosi SC, Chamberlain BL, Glausier JR, Lewis DA, Ahmari SE. Lower excitatory synaptic gene expression in orbitofrontal cortex and striatum in an initial study of subjects with obsessive compulsive disorder. Mol Psychiatry. 2021 Mar;26(3):986-998. doi: 10.1038/s41380-019-0431-3. Epub 2019 Jun 5. PMID: 31168067.
 

Trainee Name: Jonathan Cohen
Trainee: Current
Faculty Member: Daniel Kaplan, MD, PhD
Publications:

Huang H, Kuzirian MS, Cai X, Snyder LM, Cohen J, Kaplan DH, Ross SE. Generation of a NK1R-CreER knockin mouse strain to study cells involved in Neurokinin 1 Receptor signaling. Genesis. 2016 Nov;54(11):593-601. doi: 10.1002/dvg.22985. Epub 2016 Oct 31. PMID: 27712014; PMCID: PMC5241089.

Cohen JA, Edwards TN, Liu AW, Hirai T, Jones MR, Wu J, Li Y, Zhang S, Ho J, Davis BM, Albers KM, Kaplan DH. Cutaneous TRPV1+ Neurons Trigger Protective Innate Type 17 Anticipatory Immunity. Cell. 2019 Aug 8;178(4):919-932.e14. doi: 10.1016/j.cell.2019.06.022. Epub 2019 Jul 25. PMID: 31353219; PMCID: PMC6788801.

Cohen JA, Wu J, Kaplan DH. Neuronal Regulation of Cutaneous Immunity. J Immunol. 2020 Jan 15;204(2):264-270. doi: 10.4049/jimmunol.1901109. PMID: 31907268; PMCID: PMC7583491.

Saloman JL, Cohen JA, Kaplan DH. Intimate neuro-immune interactions: breaking barriers between systems to make meaningful progress. Curr Opin Neurobiol. 2020 Jun;62:60-67. doi: 10.1016/j.conb.2019.11.021. Epub 2019 Dec 13. PMID: 31841783.

Trainee Name: Miranda Culley, MD, PhD
Trainee: Current
Faculty Member: Stephen Chan, MD, PhD
Publications:

Culley MK, Chan SY. Human Endogenous Retrovirus K and Pulmonary Arterial Hypertension: A New Take on a Retro Idea. Circulation. 136,1936-38 (2017).

Culley MK, and Chan SY. Mitochondrial metabolism in pulmonary hypertension: beyond mountains there are mountains. J Clin Invest. 2018;128(9):3704-15. PMCID: PMC6118596

Cai J, Culley MK, Zhao Y, and Zhao J. The role of ubiquitination and deubiquitination in the regulation of cell junctions. Protein Cell.2018;9(9):754-69.PMCID: PMC6107491

Yu Q, Tai YY, Tang Y, Zhao J, Negi V, Culley MK, et al. BOLA (BolA Family Member 3) Deficiency Controls Endothelial Metabolism and Glycine Homeostasis in Pulmonary Hypertension. Circulation. 2019;139(19):2238-55. PMCID: PMC6519484

Yu Q, Tai YY, Tang Y, Zhao J, Negi V, Culley MK, et al. BOLA (BolA Family Member 3) Deficiency Controls Endothelial Metabolism and Glycine Homeostasis in Pulmonary Hypertension. Circulation.2019;139(19):2238-55.PMCID: PMC6519484

Culley MK, Perk D, and Chan SY. NFU1, Iron-Sulfur Biogenesis, and Pulmonary Arterial Hypertension: A (Metabolic) Shift in our Thinking. Am J Respir Cell Mol Biol.2019. PMCID: PMC6993537

Trainee Name: Samuel Dienel
Trainee: Current
Faculty Member: David Lewis, MD
Publications:

Dienel SJ, Bazmi HH, Lewis DA. Development of transcripts regulating dendritic spines in layer 3 pyramidal cells of the monkey prefrontal cortex: Implications for the pathogenesis of schizophrenia. Neurobiol Dis. 2017 Sep;105:132-141. doi: 10.1016/j.nbd.2017.05.016. Epub 2017 May 31.

Hoftman GD, Dienel SJ, Bazmi HH, Zhang Y, Chen K, Lewis DA. Altered Gradients of Glutamate and Gamma-Aminobutyric Acid Transcripts in the Cortical Visuospatial Working Memory Network in Schizophrenia. Biol Psychiatry. 2018 Apr 15;83(8):670-679. doi: 10.1016/j.biopsych.2017.11.029. Epub 2017 Dec 7.

Dienel SJ, Lewis DA. Alterations in cortical interneurons and cognitive function in schizophrenia. Neurobiol Dis. 2019 Nov;131:104208. doi: 10.1016/j.nbd.2018.06.020. Epub 2018 Jun 22.

Dienel SJ, Enwright JF 3rd, Hoftman GD, Lewis DA. Markers of glutamate and GABA neurotransmission in the prefrontal cortex of schizophrenia subjects: Disease effects differ across anatomical levels of resolution. Schizophr Res. 2020 Mar;217:86-94. doi: 10.1016/j.schres.2019.06.003. Epub 2019 Jul 8.

Schoonover KE, Dienel SJ, Lewis DA. Prefrontal cortical alterations of glutamate and GABA neurotransmission in schizophrenia: Insights for rational biomarker development. Biomark Neuropsychiatry. 2020 Dec;3:100015. doi: 10.1016/j.bionps.2020.100015. Epub 2020 May 18.

Trainee Name: Atinuke Dosunmu-Ogunbi, PhD
Trainee: Current
Faculty Member: Adam Straub, PhD
Publications:

Dosunmu-Ogunbi AM, Wood KC, Novelli EM, Straub AC. Decoding the role of SOD2 in sickle cell disease. Blood Advances. 2019 Sep;3(17):2679-2687. DOI: 10.1182/bloodadvances.2019000527.

Trainee Name: Gaelen Dwyer, PhD
Trainee: Current
Faculty Member: Heath Turnquist, PhD
Publications:

Dwyer, G.K., Mathews, L.R., Lucas, A., Gonzalez de Peredo, A., Blazar, B.R., Girard, J.P., Shlomchik, W., Poholek, A., Turnquist, H.R. (2021). IL-33 acts as a novel costimulatory agent to generate alloreactive Type 1 T helper cells. J Clin Invest. (In revision)

Bartolacci, J.G., Behun, M., Warunek, J.J.P., Li, T., Sahu, A., Dwyer, G.K., Lucas, A., Ambrosio, F., Turnquist, H.R., and Badylak, S.F. (2021). Matrix-Bound Nanovesicle-associated IL-33 Supports Functional Recovery After Skeletal Muscle Injury by Initiating a Pro-Regenerative Macrophage Phenotypic Transition. Nature Regenerative Medicine. (In revision)

Li, T.*, Zhang, Z.*, Bartolacci, J.G., Dwyer, G.K., Liu, Q., Mathews, L.R., Velayutham, M., Roessing, A.S., Lee, Y.C., Dai, H., Shiva, S., Oberbarnscheidt, M.H., Dziki, J.L., Mullet, S.J., Wendell, S.G., Wilkinson, J.D., Webber, S.A., Wood-Trageser, M., Watkins, S.C., Demetris, A.J., Hussey, G.S., Badylak, S.F., Turnquist, H.R. (2020). Graft IL-33 regulates infiltrating macrophages to protect against chronic rejection. J Clin Invest. *Co-first authors

Liu, Q.*, Dwyer, G.K.*, Zhao, Y., Huihua L., Mathews, L.R., Chakka, A.B., Chandran, U.R., Thomson, A.W., Fan, M., Billiar, T.R., and Turnquist, H.R. (2019). IL-33-mediated IL-13 secretion by ST2+ Treg controls inflammation after lung injury. JCI Insight. *Co-first authors, equally contributed to this work.

Trainee Name: George Gabriel, PhD
Trainee: Current
Faculty Member: Cecilia Lo, PhD
Publications:

Gabriel GC, Pazour GJ, Lo CW. Congenital Heart Defects and Ciliopathies Associated With Renal Phenotypes. Front Pediatr. 2018 Jun 15;6:175. doi: 10.3389/fped.2018.00175. eCollection 2018.

Gabriel GC, Young CB, Lo CW. Role of cilia in the pathogenesis of congenital heart disease. Semin Cell Dev Biol. 2020 May 14:S1084-9521(19)30166-1. doi: 10.1016/j.semcdb.2020.04.017. Online ahead of print.

Gabriel GC, Lo   CW. Left-right patterning in congenital heart disease beyond heterotaxy. Am J Med Genet C Semin Med Genet. 2020 Mar;184(1):90-96. doi: 10.1002/ajmg.c.31768. Epub 2020 Jan 30.

Trainee Name: Jenna Gale
Trainee: Current
Faculty Member: Elias Aizenman, PhD
Publications:

Gale JR, Kosobucki GJ, Hartnett-Scott KA, Aizenman E. Imprecision in Precision Medicine: Differential Response of a Disease-Linked GluN2A Mutant to NMDA Channel Blockers. Front Pharmacol. 2021 Oct 28;12:773455. doi: 10.3389/fphar.2021.773455. PMID: 34776984; PMCID: PMC8581401.

Gale JR, Nowicki KW, Wolfe RM, Sefcik RK, Abel TJ. Infection of arachnoid cyst associated with vasospasm and stroke in a pediatric patient: case report. J Neurosurg Pediatr. 2020 Aug 28:1-5. doi: 10.3171/2020.5.PEDS20419. Epub ahead of print. PMID: 32858508

Nowicki KW, Gale JR, Agarwal V, Monaco EA 3rd. Pneumomyelia Secondary to Interlaminar Cervical Epidural Injection Causing Acute Cord Injury with Transient Quadriparesis. World Neurosurg. 2020 Nov;143:434-439. doi: 10.1016/j.wneu.2020.08.090. Epub 2020 Aug 18. PMID: 32822950.

Trainee Name: Shohini Ghosh-Choudhary
Trainee: Current
Faculty Member: Toren Finkel, MD, PhD
Publications:

Ghosh-Choudhary, Shohini1; Carleton, Neil2; Flynn, JoAnne L. PhD3; Kliment, Corrine R. MD, PhD4 Strategies for Achieving Gender Equity and Work–Life Integration in Physician-Scientist Training, Academic Medicine: July 20, 2021 - Volume - Issue - doi: 10.1097/ACM.0000000000004246

Trainee Name: Gabrielle Gilmer
Trainee: Current
Faculty Member: Fabrisia Ambrosio, PhD, MPT
Publications:

Iijima H, Gilmer G, Wang K, Sivakumar S, Evans C, Matsui Y, Ambrosio F. Meta-analysis integrated with multi-omics data analysis to elucidate pathogenic mechanisms of age-related knee osteoarthritis in mice. J Gerontol A Biol Sci Med Sci. 2022 Jan 3:glab386. doi: 10.1093/gerona/glab386. Epub ahead of print. PMID: 34979545.
 

Trainee Name: Michael Granovetter
Trainee: Current
Faculty Member: Marlene Behrmann, PhD
Publications:

Granovetter MC, Burlingham CS, Blauch NM, Minshew NJ, Heeger DJ, Behrmann M. Uncharacteristic Task-Evoked Pupillary Responses Implicate Atypical Locus Ceruleus Activity in Autism. J Neurosci. 2020 May 6;40(19):3815-3826. doi: 10.1523/JNEUROSCI.2680-19.2020. Epub 2020 Apr 6. PMID: 32253362; PMCID: PMC7204084.

Maallo AMS, Granovetter MC, Freud E, Kastner S, Pinsk MA, Patterson C, Behrmann M. Large-scale resculpting of cortical circuits in children after surgical resection. Sci Rep. 2020 Dec 9;10(1):21589. doi: 10.1038/s41598-020-78394-z. PMID: 33299002; PMCID: PMC7725819.

Trainee Name: Lloyd Harvey
Trainee: Current
Faculty Member: Stephen Chan, MD, PhD
Publications:

Harvey LD, Chan SY. Evolving systems biology approaches to understanding non-coding RNAs in pulmonary hypertension. J Physiol. 2018. PubMed PMID: 30113078.

Harvey LD, Chan SY. YAPping About Glutaminolysis in Hepatic Fibrosis. Gastroenterology. 2018;154(5):1231-1233.

Ranchoux B, Harvey LD, Ayon RJ, et al. Endothelial dysfunction in pulmonary arterial hypertension: an evolving landscape (2017 Grover Conference Series). Pulm Circ. 2018;8(1):2045893217752912. PubMed PMID: 29283043; PubMed Central PMCID: PMC5798691.

Harvey LD, Chan SY. Emerging Metabolic Therapies in Pulmonary Arterial Hypertension. J Clin Med. 2017;6(4). PubMed PMID: 28375184; PubMed Central PMCID: N/A.

Begum G*, Harvey L*, Dixon CE, Sun D. ER stress and effects of DHA as an ER stress inhibitor. Translational Stroke Research. 2013;4(6):635-42. Epub 2013/12/11. doi: 10.1007/s12975-013-0282-1. PubMed PMID: 24323417; PubMed Central PMCID: PMC3864671. *denotes co-first authorship.

Harvey L, Yin Y, Attarwala IY, Begum G, Deng J, Yan HQ, Dixon CE, Sun D. Administration of DHA reduces ER stress-associated inflammation and alters microglial or macrophage activation in traumatic brain injury. ASN Neuro. 2015;7(6). PubMed PMID: 26685193; PubMed Central PMCID: PMC4710127.

Zonouzi M, Scafidi J, Li P, McEllin B, Edwards J, Dupree JL, Harvey L, Sun D, Hubner CA, Cull-Candy SG, Farrant M, Gallo V. GABAergic regulation of cerebellar NG2 cell development is altered in perinatal white matter injury. Nature Neuroscience. 2015;18(5):674-82. Epub 2015/03/31. doi: 10.1038/nn.3990. PubMed PMID: 25821912; PubMed Central PMCID: PMC4459267.

Trainee Name: Ruby Holland
Trainee: Current
Faculty Member: Sarah Ross, PhD
Publications:

Holland RA, Ross SE. Beyond lidocaine: selective voltage-gated sodium channel blockade for vaginal pain. Pain. 2021 Jan;162(1):1-3. doi: 10.1097/j.pain.0000000000002037. PMID: 32773604.

Trainee Name: Bryan Hurtle
Trainee: Current
Faculty Member: Amantha Thathiah, PhD
Publications:

Mann JR, Gleixner AM, Gomes E, DeChellis-Marks MR, Needham PG, Hurtle B, Portz B, Mauna JC, Calder CB, Copley KE, Wills ZP, Pandey UB, Brodsky JL, Thathiah A, Shorter J, Donnelly, CJ. RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43. (2019) Neuron. 102:321-338.

Trainee Name: Deepa Issar
Trainee: Current
Faculty Member: Matthew Smith, PhD
Publications:


Johnston R, Snyder AC, Khanna SB, Issar D, Smith MA. The Eyes Reflect an Internal Cognitive State Hidden in the Population Activity of Cortical Neurons. Cereb Cortex. 2021 Dec 29:bhab418. doi: 10.1093/cercor/bhab418. Epub ahead of print. PMID: 34963140.

Issar D, Williamson RC, Khanna SB, Smith MA. A neural network for online spike classification that improves decoding accuracy. J Neurophysiol. 2020 Apr 1;123(4):1472-1485. doi: 10.1152/jn.00641.2019. Epub 2020 Feb 26. PubMed PMID: 32101491.

Johnston R, Snyder A, Khanna S, Issar D, Smith M. The eyes reflect an internal cognitive state hidden in the population activity of cortical neurons. [preprint]. 2020 June; doi: 10.1101/2020.06.29.178251.

Snyder AC, Issar D, Smith MA. What does scalp electroencephalogram coherence tell us about long-range cortical networks? Eur J Neurosci. 2018 Oct;48(7):2466-2481. doi: 10.1111/ejn.13840. Epub 2018 Feb 13. PMID: 29363843; PMCID: PMC6497452.

Trainee Name: Adriana Johnson, PhD
Trainee: Current
Faculty Member: Shyam Visweswaran, MD, PhD
Publications:

Johnson A, Cooper GF, Visweswaran S. Patient-specific modeling with personalized decision paths. In: Virtual AMIA Fall Symposium. November 2020.

Trainee Name: Jeffrey (Yong Joon) Kim
Trainee: Current
Faculty Member: Angela Gronenborn, PhD
Publications:

Cryo-EM structure of the yeast TREX complex and coordination with the SR-like protein Gbp2. Yihu Xie, Bradley P. Clarkea, Yong Joon Kim, Austin L. Iveya, Pate S. Hilla, Yi Shi, and Yi Ren. bioRxiv 2021.01.04.425184

Trainee Name: Alexandar Layden, PhD
Trainee: Current
Faculty Member: Janet Catov, PhD
Publications:

Medina-Rivera M, Centeno-Tablante E, Finkelstein JL, Rayco-Solon P, Peña-Rosas JP, Garcia-Casal MN, Rogers L, Ridwan P, Martinez SS, Andrade J, Layden AJ, Chang J, Zambrano MP, Ghezzi-Kopel K, Mehta S. Presence of Ebola virus in breast milk and risk of mother-to-child transmission: synthesis of evidence. Ann N Y Acad Sci. 2020 Oct 28. doi: 10.1111/nyas.14519. Epub ahead of print. PMID: 33113592.

Layden A, 2018, B-Vitamins and HIV/AIDS, Nutrition and HIV/AIDS.

Layden A, Täse K, Finkelstein J, 2018, Neglected tropical diseases and vitamin B12: a review of the current evidence, Transactions of the Royal Society of Tropical Medicine and Hygiene, 112:423-435.

Finkelstein J, Colt S, Layden A, Krisher J, Stewart-Ibarra A, Polhemus M, Beltrán-Ayala E, Tedesco J, Cárdenas W, Endy T, Mehta S, 2020, Micronutrients, Immunological Parameters, and Dengue Virus Infection in Coastal Ecuador: A Nested Case-Control Study in an Infectious Disease Surveillance Program, The Journal of infectious diseases, 221:91-101.

Trainee Name: Andrew Liu
Trainee: Current
Faculty Member: Daniel Kaplan, MD, PhD
Publications:

Cohen JA, Edwards TN, Liu AW, Hirai T, Jones MR, Wu J, Li Y, Zhang S, Ho J, Davis BM, Albers KM, Kaplan DH. Cutaneous TRPV1+ Neurons Trigger Protective Innate Type 17 Anticipatory Immunity. Cell. 2019 Aug 8;178(4):919-932.e14. doi: 10.1016/j.cell.2019.06.022. Epub 2019 Jul 25. PMID: 31353219; PMCID: PMC6788801.

Trainee Name: Philip Mannes
Trainee: Current
Faculty Member: Sina Tavakoli, MD, PhD
Publications:


Mannes PZ, Tavakoli S. Imaging Immunometabolism in Atherosclerosis. J Nucl Med. 2021 Jul 1;62(7):896-902. doi: 10.2967/jnumed.120.245407. Epub 2021 May 7. PMID: 33963045; PMCID: PMC8882876.

Mannes PZ, Wang TL, Ma W, Selzer J, Blanco C. Student Substance Use Policies in US Allopathic Medical Schools: A National Study. JAMA Psychiatry. 2021 Dec 1;78(12):1393-1395. doi: 10.1001/jamapsychiatry.2021.2666. PMID: 34586347; PMCID: PMC8482301.

Wagner S , Sudhamalla B , Mannes P, Sappa S , Kavoosi S , Dey D , Wang S , Islam K . Engineering bromodomains with a photoactive amino acid by engaging 'Privileged' tRNA synthetases. Chem Commun (Camb). 2020 Mar 28;56(25):3641-3644. doi: 10.1039/c9cc09891g. Epub 2020 Feb 28. PMID: 32107512; PMCID: PMC7146825.

Demirdelen S, Mannes PZ, Aral AM, Haddad J, Leers SA, Gomez D, Tavakoli S. Divergence of acetate uptake in proinflammatory and inflammation-resolving macrophages: implications for imaging atherosclerosis. J Nucl Cardiol. 2021. Epub 2021/01/10. doi: 10.1007/s12350-020-02479-5. PubMed PMID: 33420659.

Trainee Name: Amir Mina
Trainee: Current
Faculty Member: Shyam Visweswaran, MD, PhD
Publications:

Melachuri SR, Melachuri MK, Mina A, Anetakis K, Crammond DJ, Balzer JR, Shandal V, Thirumala PD. Optimal "Low" Pedicle Screw Stimulation Threshold to Predict New Postoperative Lower-Extremity Neurologic Deficits During Lumbar Spinal Fusions. World Neurosurg. 2021 Jul;151:e250-e256. doi: 10.1016/j.wneu.2021.04.022. Epub 2021 Apr 16. PMID: 33872842.
 

Trainee Name: Laura Molina, PhD
Trainee: Current
Faculty Member: Paul Monga, MD
Publications:

Molina L, Zhu J, Li Q, Pradhan-Sundd T, Krutsenko Y, Sayed K, Jenkins N, Vats R, Bhushan B, Ko S, Hu S, Poddar M, Singh S, Tao J, Sundd P, Singhi A, Watkins S, Ma X, Benos PV, Feranchak A, Michalopoulos G, Nejak-Bowen K, Watson A, Bell A, Monga SP. Compensatory hepatic adaptation accompanies permanent absence of intrahepatic biliary network due to YAP1 loss in liver progenitors. Cell Reports, 2021, Jul 6. PMID: 34233187

Hirsch T*, Pilet J*, Morcrette G*, Roehrig A, Monteiro B, Molina L, Bayard Q, Trépo E, Meunier L, Caruso S, Renault V, Deleuze JF, Fresneau B, Chardot C, Gonzales E, Jacquemin E, Guerin F, Fabre M, Aerts I, Taque S, Laithier V, Branchereau S, Guettier C, Brugières L, Rebouissou S, Letouzé E, Zucman-Rossi J. Integrated genomic analysis identifies driver genes and cisplatin-resistant progenitor phenotype in pediatric liver cancer. Cancer Discovery, 2021, in press. *co-first authors. PMID: 33893148

Bhushan B, Molina L, Koral K, Stoops JW, Mars WM, Banerjee S, Orr A, Paranjpe S, Monga SP, Locker J, Michalopoulos GK. Yap is crucial for CAR-driven hepatocyte proliferation but not for induction of drug metabolism genes in mice. Hepatology, 2020 Aug 13. PMID: 32794202

Ko S, Russell JO, Molina LM, Monga SP. Liver Progenitors and Adult Cell Plasticity in Hepatic Injury and Repair: Knowns and Unknowns. Annu Rev Pathol. 2020 Jan 24;15:23-50. doi: 10.1146/annurev-pathmechdis-012419-032824. Epub 2019 Aug 9.

Bhushan B, Molina L, Koral K, Stoops JW, Mars WM, Banerjee S, Orr A, Paranjpe S, Monga SP, Locker J, Michalopoulos GK. Yap is crucial for CAR-driven hepatocyte proliferation, but not for induction of drug metabolism genes in mice. Hepatology. 2020 Aug 13. doi: 10.1002/hep.31521. Online ahead of print.

Min Q, Molina L, Li J, Adebayo Michael AO, Russell JO, Preziosi ME, Singh S, Poddar M, Matz-Soja M, Ranganathan S, Bell AW, Gebhardt R, Gaunitz F, Yu J, Tao J, Monga SP. β-Catenin and Yes-Associated Protein 1 Cooperate in Hepatoblastoma Pathogenesis. Am J Pathol. 2019 May;189(5):1091-1104. doi: 10.1016/j.ajpath.2019.02.002. Epub 2019 Feb 19.

Molina L, Yang H, Michael AOA, Oertel M, Bell A, Singh S, Chen X, Tao J, Monga SP. Correction: mTOR inhibition affects Yap1-β-catenin-induced hepatoblastoma growth and development. Oncotarget. 2019 Sep 24;10(54):5670. doi: 10.18632/oncotarget.27218. eCollection 2019 Sep 24.

Pradhan-Sundd T, Vats R, Russell JO, Singh S, Michael AA, Molina L, Kakar S, Cornuet P, Poddar M, Watkins SC, Nejak-Bowen KN, Monga SP, Sundd P. Dysregulated Bile Transporters and Impaired Tight Junctions During Chronic Liver Injury in Mice. Gastroenterology. 2018 Oct;155(4):1218-1232.e24. doi: 10.1053/j.gastro.2018.06.048. Epub 2018 Jun 30.

Pradhan-Sundd T, Zhou L, Vats R, Jiang A, Molina L, Singh S, Poddar M, Russell J, Stolz DB, Oertel M, Apte U, Watkins S, Ranganathan S, Nejak-Bowen KN, Sundd P, Monga SP. Dual catenin loss in murine liver causes tight junctional deregulation and progressive intrahepatic cholestasis. Hepatology. 2018 Jun;67(6):2320-2337. doi: 10.1002/hep.29585. Epub 2018 Apr 19.

Molina L, Bell D, Tao J, Preziosi M, Pradhan-Sundd T, Singh S, Poddar M, Luo J, Ranganathan S, Chikina M, Monga SP. Hepatocyte-Derived Lipocalin 2 Is a Potential Serum Biomarker Reflecting Tumor Burden in Hepatoblastoma. Am J Pathol. 2018 Aug;188(8):1895-1909. doi: 10.1016/j.ajpath.2018.05.006. Epub 2018 Jun 18.

Trainee Name: Shruti Nanivadekar
Trainee: Current
Faculty Member: Aryn Gittis, PhD
Publications:

Spix TA, Nanivadekar S, Toong N, Kaplow IM, Isett BR, Goksen Y, Pfenning AR, Gittis AH. Population-specific neuromodulation prolongs therapeutic benefits of deep brain stimulation. Science. 2021 Oct 8;374(6564):201-206. doi: 10.1126/science.abi7852. Epub 2021 Oct 7. PMID: 34618556.

Trainee Name: Eileen Nguyen, PhD
Trainee: Current
Faculty Member: Sarah Ross, PhD
Publications:

Nguyen E, Lim G, Ross SE. Evaluation of Therapies for Peripheral and Neuraxial Opioid-induced Pruritus based on Molecular and Cellular Discoveries. Anesthesiology. 2021 Aug 1;135(2):350-365. doi: 10.1097/ALN.0000000000003844. PMID: 34237130.

Nguyen, E, Lim, G, Ding, H, Hachisuka, J, Ko, M.-C, and Ross, S.E. 2021. Morphine acts on spinal dynorphin neurons to cause itch through disinhibition. Science Translational Medicine.

Nguyen, E, Lim, G, and Ross, S.E. 2021. Mechanistic insights into spinal neurones involved in neuraxial opioid-induced pruritus. British Journal of Anaesthesia.

Chiang MC, Nguyen E, Bustos M, Papale A, and Ross SE. 2020. Divergent neural pathways emanating from the lateral parabrachial nucleus mediate distinct components of the pain response. Neuron.

Fuller A, Parmhans N, Nguyen E, et al. 2020. Identification of Retinal Ganglion Cell Types and Brain Nuclei expressing the transcription factor Brn3c/Pou4f3 using a Cre recombinase knock-in allele. Journal of Comparative Neurology.

Trainee Name: Hector Nieves-Rosado
Trainee: Current
Faculty Member: Lawrence Kane, PhD
Publications:

Banerjee H, Nieves-Rosado H, Kulkarni A, Murter B, McGrath KV, Chandran UR, Chang A, Szymczak-Workman AL, Vujanovic L, Delgoffe GM, Ferris RL, Kane LP. Expression of Tim-3 drives phenotypic and functional changes in Treg cells in secondary lymphoid organs and the tumor microenvironment. Cell Rep. 2021 Sep 14;36(11):109699. doi: 10.1016/j.celrep.2021.109699. PMID: 34525351.

Trainee Name: Maryanna Owoc, PhD
Trainee: Current
Faculty Member: Karl Kandler, PhD , Srivatsun Sadagopan, PhD
Publications:

Reitz, KM, Terhorst, L, Smith, CN, Campwala, IK, Owoc, MS, Downs-Canner, SM, Diego, EJ, Switzer, GE, Rosengart, MR, Myers, SP. Healthcare providers’ perceived support from their organization is associated with lower burnout and anxiety amid the COVID-19 pandemic. Plos One. 2021 Nov 19. PMID: 34797847, PMCID: PMC8604356  

Baddour K, Fadel M, Zhao M, Corcoran M, Owoc MS, Thomas TH, Sabik LM, Nilsen ML, Ferris RL, Mady LJ. The cost of cure: Examining objective and subjective financial toxicity in head and neck cancer survivors. Head Neck. 2021 Jul 8. PMID: 34235804

Mady LJ, Lyu L, Owoc MS, Peddada SD, Thomas TH, Sabik LM, Johnson JT, Nilsen ML. Understanding financial toxicity in head and neck cancer survivors. Oral Oncology. 2019 Aug. PMID: 31345389

Trainee Name: BaDoi Phan
Trainee: Current
Faculty Member: Andreas Pfenning, PhD
Publications:

Chen HC, Polisetty TS, Zhu K, Phan BN, Durr NJ, Tian J, Mahoney NR. A quantitative analysis of factors influencing lower lid retraction and involutional ectropion. J Plast Reconstr Aesthet Surg. 2019 Jan;72(1):137-171. doi: 10.1016/j.bjps.2018.10.020. Epub 2018 Nov 2. PubMed PMID: 30467002. 


Perez JL, Ozpinar A, Kano H, Phan B, Niranjan A, Lunsford LD. Salvage Stereotactic Radiosurgery in Breast Cancer Patients with Multiple Brain Metastases. World Neurosurg. 2019 May;125:e479-e486. doi: 10.1016/j.wneu.2019.01.108. Epub 2019 Jan 31. PubMed PMID: 30710716. 


Phan, B.N., Bohlen, J.F., Davis, B.A. et al. A myelin-related transcriptomic profile is shared by Pitt–Hopkins syndrome models and human autism spectrum disorder. Nat Neurosci 23, 375–385 (2020). https://doi.org/10.1038/s41593-019-0578-x

Srinivasan C*, Phan BN*, Lawler AJ, Ramamurthy E, Kleyman M, Brown AR, Kaplow IM, Wirthlin ME, Pfenning AR. Addiction-associated genetic variants implicate brain cell type- and region-specific cis-regulatory elements in addiction neurobiology. bioRxiv 2020.09.29.318329; doi: https://doi.org/10.1101/2020.09.29.318329. In review


Seney ML, Moon-Kim S, Glausier JR, Hildebrand MA, XiangningXue, Zong W, Wang J, Shelton MA, Phan BN, Srinivasan C, Pfenning AR, Tseng GC, Lewis DA, Freyberg Z, Logan RW. Transcriptional alterations in opioid use disorder reveal an interplay between neuroinflammation and synaptic remodeling.bioRxiv 2020.09.14.296707; doi: https://doi.org/10.1101/2020.09.14.296707. In review


Phan BN, Bohlen JF, Davis BA, Ye Z, Chen HY, Mayfield B, Sripathy SR, Cerceo Page S, Campbell MN, Smith HL, Gallop D, Kim H, Thaxton CL, Simon JM, Burke EE, Shin JH, Kennedy AJ, Sweatt JD, Philpot BD, Jaffe AE, Maher BJ. A myelin-related transcriptomic profile is shared by Pitt-Hopkins syndrome models and human autism spectrum disorder. Nat Neurosci. 2020 Feb 3;. doi: 10.1038/s41593-019-0578-x. [Epub ahead of print] PubMed PMID: 32015540. 


Burke EE, Chenoweth JG, Shin JH, Collado-Torres L, Kim SK, Micali N, Wang Y, Colantuoni C, Straub RE, Hoeppner DJ, Chen HY, Sellers A, Shibbani K, Hamersky GR, Diaz Bustamante M, Phan BN, Ulrich WS, Valencia C, Jaishankar A, Price AJ, Rajpurohit A, Semick SA, Bürli RW, Barrow JC, Hiler DJ, Page SC, Martinowich K, Hyde TM, Kleinman JE, Berman KF, Apud JA, Cross AJ, Brandon NJ, Weinberger DR, Maher BJ, McKay RDG, Jaffe AE. Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs. Nat Commun. 2020 Jan 23;11(1):462. doi: 10.1038/s41467-019-14266-z. PubMed PMID: 31974374; PubMed Central PMCID: PMC6978526. 


Maynard KR, Tippani M, Takahashi Y, Phan BN, Hyde TM, Jaffe AE, Martinowich K. dotdotdot: an automated approach to quantify multiplex single molecule fluorescent in situ hybridization (smFISH) images in complex tissues. Nucleic Acids Research, Volume 48, Issue 11, 19 June 2020, Page e66, https://doi.org/10.1093/nar/gkaa312


Srinivasan C, Phan BN, Lawler AJ, Ramamurthy E, Kleyman M, Brown AR, Kaplow IM, Wirthlin ME, Pfenning AR. Addiction-associated genetic variants implicate brain cell type- and region-specific cis-regulatory elements in addiction neurobiology. J Neurosci. 2021 Aug 30:JN-RM-2534-20. doi: 10.1523/JNEUROSCI.2534-20.2021. Epub ahead of print. PMID: 34462306.

Trainee Name: Joshua Tashman, PhD
Trainee: Current
Faculty Member: Adam Feinberg, PhD
Publications:

3D printing of collagen to rebuild components of the heart.

A. Lee*, A. R. Hudson*, D. J. Shiwarski, J. W. Tashman, T. J. Hinton, S. Yerneni, J. Bliley, and Adam W. Feinberg. Science. 365, 6452 (2019); doi: 10.1126/science.aav9051.

 

Organ-on-e-chip: Three-dimensional self-rolled biosensor array for electrical interrogations of human electrogenic spheroids.

A. Kalmykov, C. Huang, J. Bliley,1 D. J. Shiwarski, J. W. Tashman, A. Abdullah, S. Rastogi, E. Mataev, A. W. Feinberg, K. J. Hsia, T. Cohen-Karni. Science Advances. 5, 8 (2019); doi: 10.1126/sciadv.aax0729.

 

3D Printed Biaxial Stretcher Compatible with Live Fluorescence Microscopy

D. J. Shiwarski*, J. W. Tashman *, A. Eaton, G. Apodaca, A. W. Feinberg. HardwareX. 7, e00095 (2020).

 

Fibronectin-Based Nanomechanical Biosensors to Map 3D Mechanical Strain in Live Cells and Tissues

D. J. Shiwarski*, J. W. Tashman*, A. Tsamis, Malachi Blundon, E. A. Michel, B. McCartney, L. Davidson, and A. W. Feinberg. Nat. Commun. 11 (2020), doi:10.1038/s41467-020-19659-z.

 

FRESH 3D Bioprinting a Full-Size Model of the Human Heart

E. Mirdamadi, J. W. Tashman, D. J. Shiwarski, R. N. Palchesko, A. W. Feinberg, ACS Biomater. Sci. Eng. 6, 6453–6459 (2020).

 

3D Bioprinting using UNIversal Orthogonal Network (UNION) Bioinks

S. M. Hull, C. D. Lindsay, L. G. Brunel, D. J. Shiwarski, J. W. Tashman, J. G. Roth, D. Myung, A. W. Feinberg, S. C. Heilshorn. Adv. Funct. Mater. n/a, 2007983.

 

Transparent Support Bath for Embedded 3D Printing and System for In Process Monitoring.

J.W. Tashman, D. J. Shiwarski, F. Lanni, A. W. Feinberg. U.S. Provisional Patent 63/082621

 

Emergence of FRESH 3D Printing as a Platform for Advanced Tissue Biofabrication

D. J. Shiwarski, A. R. Hudson, J. W. Tashman, A. W. Feinberg. APL Bioeng. 5, 010904 (2021).

 

Dynamic Loading of Human Engineered Heart Tissue Improves Contractility and Provokes Cardiac Disease

J. M. Bliley*, M. Vermeer*, R. Duffy, I. Batalov, D. Kramer, J. W. Tashman, D. J. Shiwarski, A. Lee, A. S. Teplenin, L. Volkers, B. Coffin, M. F. Hoes, A. Kalmykov, R. Palchesko, Y. Sun, J. D. H. Jongbloed, N. Bomer, R.. A. de Boer, A. J. H. Suurmeijer, D. A. Pijnappels, M. C. Bolling, P. van der Meer, A. W. Feinberg. Science Translational Medicine. Accepted

 

A High Performance Open-source Syringe Extruder Optimized for Extrusion and Retraction during FRESH 3D Bioprinting

J. W. Tashman*, D. J. Shiwarski*, A. W. Feinberg. HardwareX. 9, e00170 (2021).

 

FRESH 3D Bioprinting a Contractile Heart Tube Using Human Stem Cell-Derived Cardiomyocytes

J. M. Bliley, J. W. Tashman, D. J. Shiwarski, M. A. Stang, A. Lee, B. Coffin, A. Behre, A. R. Hudson, A. W. Feinberg. Biofabrication. In Revision

 

Long-fiber Embedded Hydrogel 3D Printing for Structural Reinforcement

W. Sun, J. W. Tashman, D. J. Shiwarski, A. W. Feinberg, and V. A. Webster-Wood. Submitted to ACS Biomater. Sci. Eng

 

In Situ Volumetric Imaging and Analysis of FRESH 3D Bioprinted Constructs Using Optical Coherence Tomography

J. W. Tashman*, D. J. Shiwarski*, A. Ruesch, F. Lanni, J. M. Kainerstorfer, A. W. Feinberg. Preprint on bioRxiv Prepared for submission to Science Advances.

 

A Low-Cost, Open-Source Bioprinter Conversion with the Replistruder 4

J. W. Tashman*, D. J. Shiwarski*, A.W.Feinberg. Prepared for submission to Scientific Reports.

 

FRESH Printed Patient-Specific Extracellular Matrix Patches for Volumetric Muscle Loss

A. Behre1*, J. W. Tashman1*, D. J. Shiwarski1, R. Crum2, S. Johnson2, G. Hussey2, S. F. Badylak2, A. W. Feinberg1.3. In Preparation

 

Understanding the Role of Rheology, Deformability, and Pathing for the 3D Printing of Silicone Prepolymers using Freeform Reversible Embedding

M. A. Stang, J. W. Tashman, D. J.  Shiwarski, H. Yang, L. Yao, A. W. Feinberg. In Preparation

 

*  indicates co-first authorship

 

Trainee Name: Roger Tieu
Trainee: Current
Faculty Member: Fadi Lakkis, MD
Publications:

Hughes AD, Zhao D, Dai H, Abou-Daya KI, Tieu R, Rammal R, Williams AL, Landsittel DP, Shlomchik WD, Morelli AE, Oberbarnscheidt MH, Lakkis FG. Cross-dressed dendritic cells sustain effector T cell responses in islet and kidney allografts. J Clin Invest. 2020 Jan 2;130(1):287-294. doi: 10.1172/JCI125773. PMID: 31763998; PMCID: PMC6934226.

Trainee Name: Paolo Vignali
Trainee: Current
Faculty Member: Greg Delgoffe, PhD
Publications:

Watson MJ, Vignali PDA, Mullett SJ, Overacre-Delgoffe AE, Peralta R, Grebinowski S, Menk AV, Rittenhouse NL, DePeaux K, Whetstone RD, Vignali DAA, Hand TW, Poholek AC, Morrison BM, Rothstein JD, Wendell SG, Delgoffe GM. (2021). Regulatory T cell functional identity is sustained by a glucose:lactate axis that is exploited in the tumor microenvironment. Nature. doi: https://doi.org/10.1038/s41586-020-03045-2

Scharping NE, Rivadeneria DB*, Menk AV*, Vignali PDA, Rittenhouse NL, Ford RB, Ronal P, DePeaux K, Poholek AC, Delgoffe GM. (2021). Metabolic stress induced by continuous stimulation under hypoxia rapidly promotes a terminally exhausted T cell state. Nature Immunology. doi: https://doi.org/10.1038/s41590-020-00834-9.

Trainee Name: Maxwell Wang
Trainee: Current
Faculty Member: Avniel Ghuman, PhD
Publications:

Karim HT, Wang M, Andreescu C, Tudorascu D, Butters MA, Karp JF, Reynolds CF 3rd, Aizenstein HJ. Acute trajectories of neural activation predict remission to pharmacotherapy in late-life depression. Neuroimage Clin. 2018 Jun 8;19:831-839. doi: 10.1016/j.nicl.2018.06.006. PMID: 30013927; PMCID: PMC6024196.

Karim, H. T.*, Wang, M. B.*, Andreescu, C., Tudorascu, D., Butters, M. A., Karp, J. F., ... & Aizenstein, H. J. (2018). Acute trajectories of neural activation predict remission to pharmacotherapy in late-life depression. NeuroImage: Clinical, PubMed PMID: 30013927 (*: equal contribution)

Palacios E., Owen J., Yuh E., Wang M. B., Vassar M., Ferguson A., … & Mukherjee P. (2020). The Evolution of White Matter Changes After Mild Traumatic Brain Injury. Science Advances, PubMed PMID: 32821816

Payabvash S., Palacios E., Owen J., Wang M. B., Tavassoli T., … & Marco, E. (2019). White Matter Connectome Correlates of Auditory Over-Responsivity: Edge Density Imaging and Machine-learning Classifiers. Frontiers in Integrative Neuroscience, PubMed PMID: 30983979

Payabvash, S., Palacios, E. M., Owen, J. P., Wang, M. B., Tavassoli, T., Gerdes, M., ... & Mukherjee, P. (2019). Diffusion tensor tractography in children with sensory processing disorder: Potentials for devising machine learning classifiers. NeuroImage: Clinical, 23, 101831., PMID: 31035231

Payabvash, S., Palacios, E. M., Owen, J. P., Wang, M. B., Tavassoli, T., Gerdes, M., ... & Mukherjee, P. (2019). White matter connectome edge density in children with autism spectrum disorders: potential imaging biomarkers using machine-learning models. Brain connectivity, 9(2), 209-220., PMID: 30661372

Trainee Name: Joshua Wesalo, PhD
Trainee: Current
Faculty Member: Alex Deiters, PhD
Publications:

[submitted manuscript] Joest, E. F.; Winter, C.; Wesalo, J. S.; Deiters, A.; Tampé, R. “Efficient Amber Suppression by Ribosomal Skipping for In Situ Synthesis of Photoconditional Nanobodies.” Angewandte Chemie.

Joest, E. F.; Winter, C.; Wesalo, J. S.; Deiters, A.; Tampé, R. “Light-guided intrabodies for on-demand in situ target recognition in human cells.” Chem. Sci. 2021, 12, 5787–5795.

Zhou, W.; Wesalo, J. S.; Liu, J.; Deiters, A. “Genetic code expansion in mammalian cells: A plasmid system comparison.” Bioorg. Med. Chem. 2020, 28, 115772.

Wesalo, J. S.; Deiters, A. “Fast phosphine-activated control of protein function using unnatural lysine analogues.” Methods Enzymol. 2020, 638, 191–217.

Wesalo, J. S.; Luo, J.; Morihiro, K.; Liu, J.; Deiters, A. “Phosphine-Activated Lysine Analogues for Fast Chemical Control of Protein Subcellular Localization and Protein SUMOylation.” ChemBioChem 2020, 21, 141–148

Trainee Name: Anne Wondisford
Trainee: Current
Faculty Member: Roderick O'Sullivan, PhD
Publications:

Hoang SM, Kaminski N, Bhargava R, Barroso-González J, Lynskey ML, García-Expósito L, Roncaioli JL, Wondisford AR, Wallace CT, Watkins SC, James DI, Waddell ID, Ogilvie D, Smith KM, da Veiga Leprevost F, Mellacharevu D, Nesvizhskii AI, Li J, Ray-Gallet D, Sobol RW, Almouzni G, O'Sullivan RJ. Regulation of ALT-associated homology-directed repair by polyADP-ribosylation. Nat Struct Mol Biol. 2020 Dec;27(12):1152-1164. doi: 10.1038/s41594-020-0512-7. Epub 2020 Oct 12. PMID: 33046907.

Trainee Name: Megan Yates
Trainee: Current
Faculty Member: Steffi Oesterreich, PhD
Publications:

Buck TM, Zeng X, Cantrell PS, Cattley RT, Hasanbasri Z, Yates ME, Nguyen D, Yates NA, Brodsky JL. The Capture of a Disabled Proteasome Identifies Erg25 as a Substrate for Endoplasmic Reticulum Associated Degradation. Mol Cell Proteomics. 2020 Nov;19(11):1896-1909. doi: 10.1074/mcp.RA120.002050. Epub 2020 Aug 31. PubMed PMID: 32868373; PubMed Central PMCID: PMC7664122.

Koppes EA, Redel BK, Johnson MA, Skvorak KJ, Ghaloul-Gonzalez L, Yates ME, Lewis DW, Gollin SM, Wu YL, Christ SE, Yerle M, Leshinski A, Spate LD, Benne JA, Murphy SL, Samuel MS, Walters EM, Hansen SA, Wells KD, Lichter-Konecki U, Wagner RA, Newsome JT, Dobrowolski SF, Vockley J, Prather RS, Nicholls RD. A porcine model of phenylketonuria generated by CRISPR/Cas9 genome editing. JCI Insight. 2020 Oct 15;5(20). doi: 10.1172/jci.insight.141523. PubMed PMID: 33055427; PubMed Central PMCID: PMC7605535.

Trainee Name: Zachary Yochum
Trainee: Current
Faculty Member: Burns, Timothy F.
Publications:

Delgado E, Boisen MM, Laskey R, Chen R, Song C, Sallit J, Yochum ZA, Andersen CL, Sikora MJ, Wagner J, Safe S, Elishaev E, Lee A, Edwards RP, Haluska P, Tseng G, Schurdak M, Oesterreich S. 2016, High expression of orphan nuclear receptor NR4A1 in a subset of ovarian tumors with worse outcome. Gynecol Oncol. 2016 May;141(2):348-356. doi: 10.1016/j.ygyno.2016.02.030. Epub 2016 Mar 11. PMID: 26946093 PMCID: PMC5154956

Yochum ZA, Socinski MA, Burns TF. 2016, Paradoxical functions of ZEB1 in EGFR-mutant lung cancer: tumor suppressor and driver of therapeutic resistance. J Thorac Dis. 2016 Nov;8(11):E1528-E1531. doi: 10.21037/jtd.2016.11.59. No abstract available. PMID: 28066651 PMCID: PMC5179406

Yochum ZA, Cades J, Mazzacurati L, Neumann NM, Khetarpal SK, Chatterjee S, Wang H, Attar MA, Huang EH, Chatley SN, Nugent K, Somasundaram A, Engh JA, Ewald AJ, Cho YJ, Rudin CM, Tran PT, Burns TF. 2017, A First-in-Class TWIST1 Inhibitor with Activity in Oncogene-Driven Lung Cancer. Mol Cancer Res. 2017 Dec;15(12):1764-1776. doi: 10.1158/1541-7786.MCR-17-0298. Epub 2017 Aug 29. PMID: 28851812 PMCID: PMC5712248

Godse NR, Khan N, Yochum ZA, Gomez-Casal R, Kemp C, Shiwarski DJ, Seethala RS, Kulich S, Seshadri M, Burns TF, Duvvuri U. 2017, TMEM16A/ANO1 Inhibits Apoptosis Via Downregulation of Bim Expression. Clin Cancer Res. 2017 Dec 1;23(23):7324-7332. doi: 10.1158/1078-0432.CCR-17-1561. Epub 2017 Sep 12. PMID: 28899969 PMCID: PMC5898434

Yochum ZA, Cades J, Wang H, Chatterjee S, Simons BW, O'Brien JP, Khetarpal SK, Lemtiri- Chlieh G, Myers KV, Huang EH, Rudin CM, Tran PT Burns TF 2018, Targeting the EMT transcription factor TWIST1 overcomes resistance to EGFR inhibitors in EGFR-mutant non- small-cell lung cancer. Oncogene. 2018 Aug 31. doi: 10.1038/s41388-018-0482-y. PMID: 30171258 PMCID: PMC6358506

Yochum ZA, Burns TF. TWIST1 regulation of circRNA: a novel mechanism to promote epithelial-mesenchymal transition in hepatocellular carcinoma. Noncoding RNA Investig. 2018 Dec;2. pii: 71. doi: 10.21037/ncri.2018.12.01. Epub 2018 Dec 19. No abstract available. PMID: 30734026 PMCID: PMC6363344

Trainee Name: Heather Acuff
Trainee: Past
Faculty Member: Phillips, Mary
Publications:

Acuff HE, Versace A, Bertocci MA, Ladouceur CD, Hanford LC, Manelis A, Monk K, Bonar L, McCaffrey A, Goldstein BI, Goldstein TR, Sakolsky D, Axelson D, Birmaher B, Phillips ML. Baseline and follow-up activity and functional connectivity in reward neural circuitries in offspring at risk for bipolar disorder. Neuropsychopharmacology: official publication of the American College of Neuropsychopharmacology. 2019 February 13. PubMed PMID: 30755725; DOI: 10.1038/s41386-019-0339-2.

Acuff HE, Versace A, Bertocci MA, Hanford LC, Ladouceur CD, Manelis A, Monk K, Bonar L, McCaffrey A, Goldstein BI, Goldstein TR, Sakolsky D, Axelson D, Birmaher B, Phillips ML. White matter - emotion processing activity relationships in youth offspring of bipolar parents. Journal of affective disorders. 2019 January 15;243:153-164. PubMed PMID: 30243195; PubMed Central PMCID: PMC6476540; DOI: 10.1016/j.jad.2018.09.010.

Acuff HE, Versace A, Bertocci MA, et al. Association of Neuroimaging Measures of Emotion Processing and Regulation Neural Circuitries With Symptoms of Bipolar Disorder in Offspring at Risk for Bipolar Disorder. JAMA Psychiatry. 2018;75(12):1241–1251. doi:10.1001/jamapsychiatry.2018.2318

Versace A, Ladouceur CD, Graur S, Acuff HE, Bonar LK, Monk K, McCaffrey A, Yendiki A, Leemans A, Travis MJ, Diwadkar VA, Holland SK, Sunshine JL, Kowatch RA, Horwitz SM, Frazier TW, Arnold LE, Fristad MA, Youngstrom EA, Findling RL, Goldstein BI, Goldstein T, Axelson D, Birmaher B, Phillips ML. Diffusion imaging markers of bipolar versus general psychopathology risk in youth at-risk. Neuropsychopharmacology. 2018 Oct;43(11):2212-2220. doi: 10.1038/s41386-018-0083-z. Epub 2018 May 4. PMID: 29795244; PMCID: PMC6135796.

Versace A, Acuff H, Bertocci MA, et al. White matter structure in youth with behavioral and emotional dysregulation disorders: a probabilistic tractographic study. JAMA Psychiatry. 2015;72(4):367–376. doi:10.1001/jamapsychiatry.2014.2170 ans

Trainee Name: Amin Afrazi
Trainee: Past
Faculty Member: Hackam, David
Publications:

Hackam DJ, Afrazi A, Good M, Sodhi CP. Innate immune signaling in the pathogenesis of necrotizing enterocolitis. Clin Dev Immunol. 2013;2013:475415. doi: 10.1155/2013/475415. Epub 2013 May 23. PMID: 23762089; PMCID: PMC3677005.

Afrazi A, Sodhi CP, Richardson W, Neal M, Good M, Siggers R, Hackam DJ. New insights into the pathogenesis and treatment of necrotizing enterocolitis: Toll-like receptors and beyond. Pediatr Res. 2011 Mar;69(3):183-8. doi: 10.1203/PDR.0b013e3182093280. PMID: 21135755; PMCID: PMC3125129.

Afrazi A, Branca MF, Sodhi CP, Good M, Yamaguchi Y, Egan CE, Lu P, Jia H, Shaffiey S, Lin J, Ma C, Vincent G, Prindle T Jr, Weyandt S, Neal MD, Ozolek JA, Wiersch J, Tschurtschenthaler M, Shiota C, Gittes GK, Billiar TR, Mollen K, Kaser A, Blumberg R, Hackam DJ. Toll-like receptor 4-mediated endoplasmic reticulum stress in intestinal crypts induces necrotizing enterocolitis. J Biol Chem. 2014 Apr 4;289(14):9584-99. doi: 10.1074/jbc.M113.526517. Epub 2014 Feb 11. PMID: 24519940; PMCID: PMC3975009.

Neal MD, Jia H, Eyer B, Good M, Guerriero CJ, Sodhi CP, Afrazi A, Prindle T Jr, Ma C, Branca M, Ozolek J, Brodsky JL, Wipf P, Hackam DJ. Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors. PLoS One. 2013 Jun 12;8(6):e65779. doi: 10.1371/journal.pone.0065779. PMID: 23776545; PMCID: PMC3680486.

Afrazi A, Sodhi CP, Good M, Jia H, Siggers R, Yazji I, Ma C, Neal MD, Prindle T, Grant ZS, Branca MF, Ozolek J, Chang EB, Hackam DJ. Intracellular heat shock protein-70 negatively regulates TLR4 signaling in the newborn intestinal epithelium. J Immunol. 2012 May 1;188(9):4543-57. doi: 10.4049/jimmunol.1103114. Epub 2012 Mar 28. PMID: 22461698; PMCID: PMC3331906.

Yazji I, Sodhi CP, Lee EK, Good M, Egan CE, Afrazi A, Neal MD, Jia H, Lin J, Ma C, Branca MF, Prindle T, Richardson WM, Ozolek J, Billiar TR, Binion DG, Gladwin MT, Hackam DJ. Endothelial TLR4 activation impairs intestinal microcirculatory perfusion in necrotizing enterocolitis via eNOS-NO-nitrite signaling. Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):9451-6. doi: 10.1073/pnas.1219997110. Epub 2013 May 6. PMID: 23650378; PMCID: PMC3677476.

Richardson WM, Sodhi CP, Russo A, Siggers RH, Afrazi A, Gribar SC, Neal MD, Dai S, Prindle T Jr, Branca M, Ma C, Ozolek J, Hackam DJ. Nucleotide-binding oligomerization domain-2 inhibits toll-like receptor-4 signaling in the intestinal epithelium. Gastroenterology. 2010 Sep;139(3):904-17, 917.e1-6. doi: 10.1053/j.gastro.2010.05.038. Epub 2010 May 24. PMID: 20580721; PMCID: PMC2930126.

Neal MD, Sodhi CP, Dyer M, Craig BT, Good M, Jia H, Yazji I, Afrazi A, Richardson WM, Beer-Stolz D, Ma C, Prindle T, Grant Z, Branca MF, Ozolek J, Hackam DJ. A critical role for TLR4 induction of autophagy in the regulation of enterocyte migration and the pathogenesis of necrotizing enterocolitis. J Immunol. 2013 Apr 1;190(7):3541-51. doi: 10.4049/jimmunol.1202264. Epub 2013 Mar 1. PMID: 23455503; PMCID: PMC3608826.

Good M, Siggers RH, Sodhi CP, Afrazi A, Alkhudari F, Egan CE, Neal MD, Yazji I, Jia H, Lin J, Branca MF, Ma C, Prindle T, Grant Z, Shah S, Slagle D 2nd, Paredes J, Ozolek J, Gittes GK, Hackam DJ. Amniotic fluid inhibits Toll-like receptor 4 signaling in the fetal and neonatal intestinal epithelium. Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11330-5. doi: 10.1073/pnas.1200856109. Epub 2012 Jun 25. PMID: 22733781; PMCID: PMC3396489.

Trainee Name: Matthew Amdahl
Trainee: Past
Faculty Member: Tejero Bravo, Jesus
Publications:

Amdahl, M.B., Sparacino-Watkins, C.E., Corti, P., Gladwin, M.T. & Tejero, J.‡ (2017) Efficient reduction of vertebrate cytoglobins by the cytochrome b5/cytochrome b5 reductase/NADH system. Biochemistry, 56, 3993-4004.

Amdahl, M.B., Petersen, E.E., Bocian, K.A., Kaliszuk, S.J., DeMartino, Q.W., Tiwari, S., Sparacino-Watkins, C.E., Corti, P., Rose, J.J., Gladwin, M.T., Fago, A. & Tejero, J.‡ (2019) The zebrafish cytochrome b5/cytochrome b5 reductase/NADH system reduces efficiently cytoglobins 1 and 2 – Conserved activity of Cytochrome b5/Cytochrome b5 reductases during vertebrate evolution. Biochemistry, 58, 3212-3223.

DeMartino, A.W., Amdahl, M.B., Bocian, K.A., Rose, J.J., Tejero, J. ‡ & Gladwin, M.T. ‡ (2020) Tunable redox sensor properties of human cytoglobin allosterically regulate heme pocket reactivity. Free Rad. Biol. Med., in press, https://doi.org/10.1016/j.freeradbiomed.2020.10.321.

Trainee Name: Matthew Amdahl
Trainee: Past
Faculty Member: Gladwin, Mark T.
Publications:

Amdahl MB, Petersen EE, Bocian K, Kaliszuk SJ, DeMartino AW, Tiwari S, Sparacino-Watkins CE, Corti P, Rose JJ, Gladwin MT, Fago A, Tejero J. The Zebrafish Cytochrome b5/Cytochrome b5 Reductase/NADH System Efficiently Reduces Cytoglobins 1 and 2: Conserved Activity of Cytochrome b5/Cytochrome b5 Reductases during Vertebrate Evolution. Biochemistry. 2019 Jul 23;58(29):3212-3223. doi: 10.1021/acs.biochem.9b00406. Epub 2019 Jul 10.PMID:31257865

Amdahl MB, DeMartino AW, Tejero J, Gladwin MT. 2017. Cytoglobin at the Crossroads of Vascular Remodeling. Arterioscler Throm Vasc Biol. 1803-1805. PMID: 28954806.

Amdahl MB, Sparacino-Watkins CE, Corti P, Gladwin MT, Tejero J. 2017. Efficient Reduction of Vertebrate Cytoglobins by the Cytochrome b5/Cytochrome b5 Reductase/NADH System. Biochemistry. 3993-4004. PMID: 28671819.

DeMartino AW, Rose JJ, Amdahl MB, Dent MR, Shah FA, Bain W, McVerry BJ, Kitsios GD, Tejero J, Gladwin MT. No evidence of hemoglobin damage by SARS-CoV-2 infection. Haematologica. 2020 Sep 10;Online ahead of print(12):264267. doi: 10.3324/haematol.2020.264267. PMID: 33054129; PMCID: PMC7716349.

DeMartino AW, Amdahl MB, Bocian K, Rose JJ, Tejero J, Gladwin MT. Redox sensor properties of human cytoglobin allosterically regulate heme pocket reactivity. Free Radic Biol Med. 2020 Nov 2:S0891-5849(20)31595-1. doi: 10.1016/j.freeradbiomed.2020.10.321. Epub ahead of print. PMID: 33144263.

Amdahl MB, DeMartino AW, Gladwin MT. Inorganic nitrite bioactivation and role in physiological signaling and therapeutics. Biol Chem. 2019 Dec 18;401(1):201-211. doi: 10.1515/hsz-2019-0349. PMID: 31747370.

Trainee Name: Alyce Anderson (Marsh)
Trainee: Past
Faculty Member: Binion, David
Publications:

Ferris LK, Anderson AM, Matsumoto M. Performance of Dermatology Physician Assistants - Reply. JAMA Dermatology. 2018;154(10):1229-30.

Eddens T, Kaplan DJ, Anderson AJM, Nowalk AJ, Campfield BT. Insights From the Geographic Spread of the Lyme Disease Epidemic. Clinical Infectious Diseases. 2019;68(3):426-34.

Anderson AJM, Ferris LK, Binion DG, Smith KJ. Cost-Effectiveness of Melanoma Screening in Inflammatory Bowel Disease. Digestive Diseases and Sciences. 2018;63(10):2564-72.

Anderson A, Click B, Ramos-Rivers C, Koutroubakis IE, Hashash JG, Dunn MA, et al. The Association Between Sustained Poor Quality of Life and Future Opioid Use in Inflammatory Bowel Disease. Inflammatory Bowel Diseases. 2018;24(7):1380-8.

Anderson AM, Matsumoto M, Saul MI, Secrest AM, Ferris LK. Accuracy of Skin Cancer Diagnosis by Physician Assistants Compared With Dermatologists in a Large Health Care System. JAMA Dermatology. 2018;154(5):569-73.

Anderson A, Ferris LK, Click B, Ramos-Rivers C, Koutroubakis IE, Hashash JG, et al. Low Rates of Dermatologic Care and Skin Cancer Screening Among Inflammatory Bowel Disease Patients. Digestive Diseases and Sciences. 2018;63(10):2729-39.

Regueiro M, Click B, Anderson A, Shrank W, Kogan J, McAnallen S, et al. Reduced Unplanned Care and Disease Activity and Increased Quality of Life After Patient Enrollment in an Inflammatory Bowel Disease Medical Home. Clinical Gastroenterology and Hepatology. 2018;16(11):1777-85.

Matsumoto M, Secrest A, Anderson A, Saul MI, Ho J, Kirkwood JM, et al. Estimating the cost of skin cancer detection by dermatology providers in a large health care system. Journal of the American Academy of Dermatology. 2018;78(4):701,709.e1.

Gajendran M, Bauer AJ, Buchholz BM, Watson AR, Koutroubakis IE, Hashash JG, et al. Ileocecal Anastomosis Type Significantly Influences Long-Term Functional Status, Quality of Life, and Healthcare Utilization in Postoperative Crohn's Disease Patients Independent of Inflammation Recurrence. American Journal of Gastroenterology. 2018;113(4):576-83.

Click B, Anderson AM, Ramos Rivers C, Koutroubakis IE, Hashash JG, Dunn MA, et al. Telephone Encounters Predict Future High Financial Expenditures in Inflammatory Bowel Disease Patients: A 3-Year Prospective Observational Study. Journal of Clinical Gastroenterology. 2018;52(4):319-25.

Hashash JG, Anderson AJ, Rivers CR, Koutroubakis I, Regueiro MD, Click BH, et al. Sa1856 - Is High Globulin Fraction a Biomarker of Severity in Inflammatory Bowel Disease (IBD)? Analysis of a 6-Year, Prospective Natural History Registry. Gastroenterology. 2017;152(5):S372-.

Click B, Anderson AM, Koutroubakis IE, Ramos Rivers C, Babichenko D, Machicado JD, et al. Peripheral Eosinophilia in Patients With Inflammatory Bowel Disease Defines an Aggressive Disease Phenotype. American Journal of Gastroenterology. 2017;112(12):1849-58.

Cheng DF, Anderson AJ, Rivers CR, Click BH, Koutroubakis I, Hashash JG, et al. Mo1822 - Variation in Annual Rate of Steroid Prescriptions Amongst Providers for Inflammatory Bowel Disease Patients is Dependent on Cohort Size and Disease Severity. Gastroenterology. 2017;152(5):S792-.

Boiko JR, Anderson AJM, Gordon RA. Representation of Women Among Academic Grand Rounds Speakers. JAMA Internal Medicine. 2017;177(5):722-4.

Click B, MD, Binion, David G., MD, FACG, Anderson AM, BS. Predicting Costs of Care for Patients With Inflammatory Bowel Diseases. Clinical Gastroenterology and Hepatology. 2016;2017;15(3):393-5.

Anderson A, Click B, Ramos-Rivers C, Cheng D, Babichenko D, Koutroubakis IE, et al. Lasting Impact of Clostridium difficile Infection in Inflammatory Bowel Disease: A Propensity Score Matched Analysis. Inflammatory bowel diseases. 2017;23(12):2180-8.

Anderson AJM, Click B, Ramos-Rivers C, Babichenko D, Koutroubakis IE, Hartman DJ, et al. Development of an Inflammatory Bowel Disease Research Registry Derived from Observational Electronic Health Record Data for Comprehensive Clinical Phenotyping. Digestive Diseases and Sciences. 2016;61(11):3236-45.

Jiang J, Click B, Anderson AM, Koutroubakis IE, Rivers CR, Hashash JG, et al. Group-Based Trajectory Modeling of Healthcare Financial Charges in Inflammatory Bowel Disease: A Comprehensive Phenotype. Clinical and translational gastroenterology. 2016;7(7):e181.

Cherfane C, Anderson AJ, Rivers CR, Schwartz M, Barrie A, Hashash JG, et al. 165 Is Monocytosis a Biomarker of Severity in Inflammatory Bowel Disease? Analysis of a 6 Year, Prospective Natural History Registry. Gastroenterology. 2016;150(4):S42-.

Anderson AJ, Rivers CR, Click BH, Regueiro M, Dunn MA, Hashash JG, et al. Sa1918 Weight Fluctuation in Inflammatory Bowel Disease Predicts Future Healthcare Utilization. Gastroenterology. 2016;150(4):S403-.

Anderson AJ, Rivers CR, Click BH, Cheng DF, Koutroubakis I, Hashash JG, et al. Su1810 Clostridium difficile Infection in Inflammatory Bowel Disease Predicts Future Healthcare Utilization. Gastroenterology. 2016;150(4):S559-.

Click BH, Jiang J, Anderson AJ, Koutroubakis I, Rivers CR, Hashash JG, et al. Tu1946 Can We Phenotype IBD Patients Based on Financial Charges Over Time? Trajectory Modeling of Healthcare Utilization in a Large, Prospective IBD Cohort. Gastroenterology. 2016;150(4):S986-7.

Click B, Ramos Rivers C, Koutroubakis IE, Babichenko D, Anderson AM, Hashash JG, et al. Demographic and clinical predictors of high healthcare use in patients with inflammatory bowel disease. Inflammatory Bowel Diseases. 2016;22(6):1442-9.

Click B, Vargas EJ, Anderson AM, Proksell S, Koutroubakis IE, Ramos Rivers C, et al. Silent Crohn's Disease: Asymptomatic Patients with Elevated C-reactive Protein Are at Risk for Subsequent Hospitalization. Inflammatory Bowel Diseases. 2015;21(10):2254-61.

Anderson A, Binion DG. 59.00James D.LewisFrank M.RuemmeleGary D.WuNutrition, Gut Microbiota and Immunity: Therapeutic Targets for IBD (79th Nestlé Nutrition Institute Workshop, New York, New York, September 2013)2014KargerBasel, Switzerland166ISBN: 978-3-318-02669-6. Web address for ordering:www.karger.com. Gastroenterology. 2015;149(4):1124-5.

Click B, Vargas EJ, Anderson AM, Proksell S, Koutroubakis IE, Ramos Rivers C, et al. Silent Crohn's Disease: Asymptomatic Patients with Elevated C-reactive Protein Are at Risk for Subsequent Hospitalization. Inflammatory Bowel Diseases. 2015;21(10):2254-61.

Loganathan P., Anderson A., Rivers W., Rivers C.R., Gajendran M., Binion D.G. (2016) Total Parenteral Nutrition and Inflammatory Bowel Disease: Indications, Long term Outcomes, and Complications. In: Ananthakrishnan A. (eds) Nutritional Management of Inflammatory Bowel Diseases. Springer, Cham

Du F, Marsh A, Henkel M, Ming L, McGeachy MJ. 71 : Mechanisms of IL-23 mediated Th17 inflammation. Cytokine. 2013;63(3):260-.

Neal MD, Marsh A, Marino R, Kautza B, Raval JS, Forsythe RM, et al. Massive Transfusion: An Evidence-Based Review of Recent Developments. Archives of Surgery. 2012;147(6):563-71.

Trainee Name: Mandar Aras
Trainee: Past
Faculty Member: Aizenman, Elias
Publications:

Aras M.A. and E. Aizenman. 2005, Obligatory role of ASK1 in the apoptotic surge of K+ currents. Neurosci Lett. 2005 Oct 28;387(3):136-40. PMID: 16006035 PMCID: PMC2947746

Aras, M. A.., K.A. Hartnett and E. Aizenman. 2008, Assessment of Cell Viability in Primary Neuronal Cultures. Curr Protoc Neurosci. 2008 Jul;Chapter 7:Unit 7.18. doi: 10.1002/0471142301.ns0718s44 PMID: 18633999

Hershfinkel, M., K. Kandler, M.E. Knoch, M. Dagan-Rabin, M. Aras, C. Abramovitch-Dahan, I. Sekler and E. Aizenman. 2009, Intracellular zinc inhibits KCC2 transporter activity. Nat Neurosci. 2009 Jun;12(6):725-7. doi: 10.1038/nn.2316. Epub 2009 May 10. PMID: 19430470 PMCID: PMC2737597

Aras, M.A., H. Hara, K.A. Hartnett, K. Kandler and E. Aizenman. 2009, PKC regulation of neuronal zinc signaling mediates survival during preconditioning. J Neurochem. 2009 Jul;110(1):106-17. doi: 10.1111/j.1471-4159.2009.06106.x. Epub 2009 Apr 22. PMID: 19453299 PMCID: PMC2719843

Aras, M.A., R.A. Saadi and E. Aizenman. 2009, Zn2+ regulates Kv2.1 voltage-dependent gating and localization following ischemia. Eur J Neurosci. 2009 Dec;30(12):2250-7. doi: 10.1111/j.1460-9568.2009.07026.x. Epub 2009 Dec 10. PMID: 20092568 PMCID:

Trainee Name: James Bales
Trainee: Past
Faculty Member: Dixon, Edward
Publications:

Bales, J.W., Ma, X., Yan, H.Q., Jenkins, L.W., Dixon, C.E. Expression of protein phosphatase 2b (calcineurin) subunit a isoforms in rat hippocampus following a traumatic brain injury. Journal of Neurotrauma. 2010 Jan;27(1):109-20. PMID: 19751097

Bales, J.W., Ma, X. , Yan , H.Q., Jenkins, L.W., Dixon, C.E. Regional calcineurin subunit 8 isoform expression in rat hippocampus following a traumatic brain injury. Brain Res. 2010 Oct 28;1358:211-20. PM/0: 20713027

Bales, J.W., Yan , H.Q., Ma, X., Li, Y., Samarasinghe, R. , Dixon, C.E. Dopamine and cAMP regulated phosphoprotein, 32 kDA: A novel therapeutic target in traumatic brain injury. Experimental Neurology. 2011, March. PMID: 21376040

Osier ND, Bales JW, Pugh B, Shin S, Wyrobek J, Puccio AM, Okonkwo DO, Ren D, Alexander S, Conley YP, Dixon CE. Variation in PPP3CC Genotype Is Associated with Long-Term Recovery after Severe Brain Injury. J Neurotrauma. 2017 Jan 1;34(1):86-96. doi: 10.1089/neu.2015.4343. Epub 2016 Jun 27. PMID: 27225880; PMCID: PMC5198144.

Shin SS, Bales JW, Edward Dixon C, Hwang M. Structural imaging of mild traumatic brain injury may not be enough: overview of functional and metabolic imaging of mild traumatic brain injury. Brain Imaging Behav. 2017 Apr;11(2):591-610. doi: 10.1007/s11682-017-9684-0. PMID: 28194558.

Shin SS, Bales JW, Yan HQ, Kline AE, Wagner AK, Lyons-Weiler J, Dixon CE. The effect of environmental enrichment on substantia nigra gene expression after traumatic brain injury in rats. J Neurotrauma. 2013 Feb 15;30(4):259-70. doi: 10.1089/neu.2012.2462. Epub 2013 Feb 5. PMID: 23094804; PMCID: PMC3579325.

Bales JW, Kline AE, Wagner AK, Dixon CE. Targeting Dopamine in Acute Traumatic Brain Injury. Open Drug Discov J. 2010;2:119-128. doi: 10.2174/1877381801002010119. PMID: 22308176; PMCID: PMC3269831.

Bales JW, Wagner AK, Kline AE, Dixon CE. Persistent cognitive dysfunction after traumatic brain injury: A dopamine hypothesis. Neurosci Biobehav Rev. 2009 Jul;33(7):981-1003. doi: 10.1016/j.neubiorev.2009.03.011. Epub 2009 Apr 1. PMID: 19580914; PMCID: PMC2806224.

Trainee Name: Allison Bean
Trainee: Past
Faculty Member: Tuan, Rocky
Publications:

Xue J, Lin H, Bean A, Tang Y, Tan J, Tuan RS, Wang B. One-Step Fabrication of Bone Morphogenetic Protein-2 Gene-Activated Porous Poly-L-Lactide Scaffold for Bone Induction. Mol Ther Methods Clin Dev. 2017 Sep 7;7:50-59. doi: 10.1016/j.omtm.2017.08.008. PMID: 29018836; PMCID: PMC5626914.

Bean AC, Tuan RS. Fiber diameter and seeding density influence chondrogenic differentiation of mesenchymal stem cells seeded on electrospun poly(ε-caprolactone) scaffolds. Biomed Mater. 2015 Jan 29;10(1):015018. doi: 10.1088/1748-6041/10/1/015018. PMID: 25634427; PMCID: PMC4345119.

Shimomura K, Bean AC, Lin H, Nakamura N, Tuan RS. In Vitro Repair of Meniscal Radial Tear Using Aligned Electrospun Nanofibrous Scaffold. Tissue Eng Part A. 2015 Jul;21(13-14):2066-75. doi: 10.1089/ten.TEA.2014.0549. Epub 2015 May 4. PMID: 25813386; PMCID: PMC4507122.

Trainee Name: Colin Beckwitt
Trainee: Past
Faculty Member: Wells, Alan
Publications:

Beckwitt CH, Clark AM, Ma B, Whaley D, Oltvai ZN, Wells A. Statins attenuate outgrowth of breast cancer metastases. Br J Cancer. 2018 Oct;119(9):1094-1105. doi: 10.1038/s41416-018-0267-7. Epub 2018 Nov 7. PMID: 30401978; PMCID: PMC6220112.

Beckwitt CH, Monaco SJ, Gruen GS. Primary arthrodesis of tibiotalar joint achieves comparable outcomes to ORIF in severely comminuted high-energy pilon fractures: a retrospective cohort study. Foot & Ankle Orthopedics 2018 Aug 2; 3:3

Ishikawa T, Hosaka YZ, Beckwitt C, Wells A, Oltvai ZN, and Warita K. Attenuation of HMG-CoA reductase expression potentiates the cancer cell growth-inhibitory effect of statins. Oncotarget, 2018, June 29; 9: 23904-29315.

Beckwitt CH, Shiraha K, and Wells A. Lipophilic statins limit cancer cell growth and survival, via involvement of Akt signaling. PLoS One, 2018, May 15; 13(5): e0197422.

Warita K, Warita T, Beckwitt CH, Schurdak ME, Vazquez A, Wells A, Oltvai ZN. Statin-induced mevalonate pathway inhibition attenuates the growth of mesenchymal-like cancer cells that lack functional E-cadherin mediated cell cohesion. Sci Rep. 2014 Dec 23;4:7593. doi: 10.1038/srep07593. PMID: 25534349; PMCID: PMC4274516.

Ishikawa T, Hosaka YZ, Beckwitt C, Wells A, Oltvai ZN, Warita K. Concomitant attenuation of HMG-CoA reductase expression potentiates the cancer cell growth-inhibitory effect of statins and expands their efficacy in tumor cells with epithelial characteristics. Oncotarget. 2018 Jun 29;9(50):29304-29315. doi: 10.18632/oncotarget.25448. PMID: 30034619; PMCID: PMC6047681.

Beckwitt CH, Brufsky A, Oltvai ZN, Wells A. Statin drugs to reduce breast cancer recurrence and mortality. Breast Cancer Res. 2018 Nov 20;20(1):144. doi: 10.1186/s13058-018-1066-z. PMID: 30458856; PMCID: PMC6247616

Raghu VK, Beckwitt CH, Warita K, Wells A, Benos PV, Oltvai ZN. Biomarker identification for statin sensitivity of cancer cell lines. Biochem Biophys Res Commun. 2018 Jan 1;495(1):659-665. doi: 10.1016/j.bbrc.2017.11.065. Epub 2017 Nov 14. PMID: 29146185; PMCID: PMC5827944.

Dioufa N, Clark AM, Ma B, Beckwitt CH, Wells A. Bi-directional exosome-driven intercommunication between the hepatic niche and cancer cells. Mol Cancer. 2017 Nov 14;16(1):172. doi: 10.1186/s12943-017-0740-6. PMID: 29137633; PMCID: PMC5686836.

Beckwitt CH, Clark AM, Wheeler S, Taylor DL, Stolz DB, Griffith L, Wells A. Liver 'organ on a chip'. Exp Cell Res. 2018 Feb 1;363(1):15-25. doi: 10.1016/j.yexcr.2017.12.023. Epub 2017 Dec 29. PMID: 29291400; PMCID: PMC5944300.

Trainee Name: Mehret Birru
Trainee: Past
Faculty Member: Matthews, Karen A.
Publications:

Birru MS, Matthews KA, Thurston RC, Brooks MM, Ibrahim S, Barinas-Mitchell E, Janssen I, Sutton-Tyrrell K; SWAN Heart Study, 2011, African-American ethnicity and cardiovascular risk factors are related to aortic pulse-wave velocity progression, Am J Hypertens, 24(7):809-15.

Birru MS, Monaco VM, Charles L, Drew H, Njie V, Bierria T, Detlefsen E, Steinman RA. Internet usage by low-literacy adults seeking health information: an observational analysis. J Med Internet Res. 2004 Sep 3;6(3):e25. doi: 10.2196/jmir.6.3.e25. PMID: 15471751; PMCID: PMC1550604.

Birru M, Steinman RA. Online health information and low-literacy African Americans. J Med Internet Res. 2004 Sep 3;6(3):e26. doi: 10.2196/jmir.6.3.e26. PMID: 15471752; PMCID: PMC1550609.

Trainee Name: Matthew Boyer
Trainee: Past
Faculty Member: Cheng, Tao
Publications:

XuFeng R, Boyer MJ, Shen H, Li Y, Yu H, Gao Y, Yang Q, Wang Q, Cheng T. ADAR1 is required for hematopoietic progenitor cell survival via RNA editing. Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17763-8. doi: 10.1073/pnas.0903324106. Epub 2009 Oct 2. PMID: 19805087; PMCID: PMC2764897.

Boyer MJ, Cheng T. The CDK inhibitors: potential targets for therapeutic stem cell manipulations? Gene Ther. 2008 Jan;15(2):117-25. doi: 10.1038/sj.gt.3303064. Epub 2007 Nov 8. PMID: 17989702.

Shen H, Boyer M, Cheng T. Flow cytometry-based cell cycle measurement of mouse hematopoietic stem and progenitor cells. Methods Mol Biol. 2008;430:77-86. doi: 10.1007/978-1-59745-182-6_5. PMID: 18370292.

Yuan Y, Yu H, Boyer MJ, Song X, Cao S, Shen H, Cheng T. Hematopoietic stem cells are not the direct target of spontaneous leukemic transformation in p18(INK4C)-null reconstituted mice. Cancer Res. 2006 Jan 1;66(1):343-51. doi: 10.1158/0008-5472.CAN-05-2945. PMID: 16397248.

Trainee Name: L.B. Brilli-Skvarca
Trainee: Past
Faculty Member: Hukriede, Neil
Publications:

Mo, D., Ihrke, G., Costa, S.A., Brilli, L.B., Cianciolo Cosentino, C., Hukriede, N.A., and O.A. Weis (2012) Apical Targeting and Endocytosis of the Sialomucin Endolyn are Essential for Establishment of Zebrafish Pronephric Kidney Function. J Cell Science 125(22), 5546-54. PMCID: PMC3561862

Brilli, L.B., Swanhart, L.M., de Caestecker, M., and N.A. Hukriede (2013) Histone deacetylase inhibitors in renal development and disease. Pediatric Nephrology Oct. 7 (10): 1909-27. PMCID: PMC3751322

Cianciolo Cosentino, C, Skrypnyk, N., Brilli L.B., Chiba, T., Novitskaya, T., Woods, C., West, J., Korotchenko, V.N., McDermott, L., Day, B.W., Davidson A.J., Harris, R., de Caestecker, M.P., and N.A. Hukriede (2013) Histone Deacetylase inhibitor enhances recovery after AKI. JASN May 26(6), 943-53. PMCID: PMC3665399

Chiba, T, Skrypnyk, N., Brilli Skvarca, L, Penchey, R., Zhang, K.X., Rochon, E.R., Fall, J.L., Paueksakon, P., Yang, H., Roman, B.L., Zhang, M-Z., Harris, R., Hukriede, N.A., and M.P. de Caestecker (2015) Retinoic Acid Signaling Coordinates Macrophage-Dependent Injury and Repair after Acute Kidney Injury. JASN Jun 24. pii: ASN.2014111108. PMCID: PMC4731115

Skrypnyk, N. I., Sanker, S., Brilli Skvarca, L., Woods, C., Chiba, T., Patel, K., Goldberg, N. D., McDermott, L., Vinson, P. N., Calcutt, M. W., Vernetti, L. A., Vogt, A., Huryn, D. M., Hukriede, N. A., and M. P. de Caestecker. (2016) Delayed treatment with PTBA analogues reduces post injury renal fibrosis after kidney injury. AJP-Renal Physiology 310: F705-16. PMCID: PMC4835925

Naylor R.A., Brilli Skvarca L, Thisse C, Thisse, Hukriede N.A., and Davidson AJ. (2016) The anterior–posterior axis of the non-axial mesoderm aligns with the classic dorsal-ventral axis and is sequentially patterned by the BMP and RA pathways. Nature Comm. Jul 13;7:12197. PMCID: PMC4947171

Han, H.I., Skvarca, L.B., Espiritu, E.J., Davidson, A.J., and Hukriede, N.A., (2018) The role of macrophages during acute kidney injury: destruction and repair. Pediatric Nephrology Jan 30. DOI: 10.1007/s00467-017-3883-1. PMCID: PMC6066473

Skvarca, L.B., Han, H.I, Missinato, M.A., Espiritu, E., Rochon, E.R., McDaniels, M.D., Roman, B.L., Waxman, J.S., Watkins, S., Davidson, A.J., Tsang, M., and Hukriede, N.A., (2019) Enhancing acute kidney injury regeneration by promoting cellular dedifferentiation in zebrafish. Disease Models and Mech. Apr 5;12(4). pii: dmm037390. DOI:10.1242/dmm.037390 PMCID: PMC6505474

Brilli LL, Swanhart LM, de Caestecker MP, Hukriede NA. HDAC inhibitors in kidney development and disease. Pediatr Nephrol. 2013 Oct;28(10):1909-21. doi: 10.1007/s00467-012-2320-8. Epub 2012 Oct 7. PMID: 23052657; PMCID: PMC3751322.

Naylor RW, Skvarca LB, Thisse C, Thisse B, Hukriede NA, Davidson AJ. BMP and retinoic acid regulate anterior-posterior patterning of the non-axial mesoderm across the dorsal-ventral axis. Nat Commun. 2016 Jul 13;7:12197. doi: 10.1038/ncomms12197. PMID: 27406002; PMCID: PMC4947171.

Trainee Name: Frank Cackowski
Trainee: Past
Faculty Member: Roodman, David
Publications:

Cackowski FC, Anderson JL, Patrene KD, Choksi RJ, Shapiro SD, Windle JJ, Blair HC, Roodman GD. Osteoclasts are important for bone angiogenesis. Blood. 2010; 115:140-149.

Trainee Name: Yvonne Chao
Trainee: Past
Faculty Member: Wells, Alan
Publications:

Wells A, Chao YL, Grahovac J, Wu Q, Lauffenburger DA. Epithelial and mesenchymal phenotypic switchings modulate cell motility in metastasis. Front Biosci (Landmark Ed). 2011 Jan 1;16:815-37. doi: 10.2741/3722. PMID: 21196205; PMCID: PMC4003907.

Chao Y, Wu Q, Acquafondata M, Dhir R, Wells A. Partial mesenchymal to epithelial reverting transition in breast and prostate cancer metastases. Cancer Microenviron. 2012 Apr;5(1):19-28. doi: 10.1007/s12307-011-0085-4. Epub 2011 Sep 3. PMID: 21892699; PMCID: PMC3343195.

Chao Y, Wu Q, Shepard C, Wells A. Hepatocyte induced re-expression of E-cadherin in breast and prostate cancer cells increases chemoresistance. Clin Exp Metastasis. 2012 Jan;29(1):39-50. doi: 10.1007/s10585-011-9427-3. Epub 2011 Oct 2. PMID: 21964676; PMCID: PMC3991430.

Chao YL, Shepard CR, Wells A. Breast carcinoma cells re-express E-cadherin during mesenchymal to epithelial reverting transition. Mol Cancer. 2010 Jul 7;9:179. doi: 10.1186/1476-4598-9-179. PMID: 20609236; PMCID: PMC2907333.

Trainee Name: Michael Chiang, MD, PhD
Trainee: Past
Faculty Member: Ross, Sarah
Publications:

Patel A, Abou-Al-Shaar H, Chiang MC, Algattas HN, McDowell MM, Stone JG, Mitchell EB, Emery SP, Greene S. Neuro-Ophthalmologic Manifestations of Congenital Aqueductal Stenosis. Journal of Neurosurgery Pediatrics, Submitted October 2020.

McDowell MM*, Chiang MC*, Abou-Al-Shaar H, Zenonos GA, Wang EW, Snyderman CH, Gardner PA. Applications of endoscopic endonasal surgery in early childhood. Journal of Neurosurgery Pediatrics, Submitted, September 2020.

Chiang MC, Canto-Bustos M, Nguyen EK, Papale AE, Oswald, AMM, Ross SE. Divergent pathways emanating from the lateral parabrachial nucleus mediate separable aspects of the pain response. Neuron. 2020 Apr 8. pii: S0896-6273(20)30221-X.  doi: 10.1016/j.neuron.2020.03.014. PMID: 32289251

Chiang MC*, McDowell MM*, Weaver K, Broniscer A, Greene S. Is Schimmelpenning syndrome associated with intracranial tumors? A case report. Pediatric Neurosurgery. 2019 Mar 15; 1-6. doi: 10.1159/000497149. * These two authors contributed equally to this manuscript. PMID: 30879010

McDowell MM*, Chiang MC*, Agarwal N, Ismail N, Friedlander RM, Wecht DA. Exclusive use of fixed pressure valves for cerebrospinal fluid diversion in a modern adult cohort. Heliyon. 2018 Dec 29;4(12):e01099. doi: 10.1016/j.heliyon.2018.e01099. * These two authors contributed equally to this manuscript. PMID: 30627679

Snyder LM, Chiang MC, Loeza-Alcocer E, Omori Y, Hachisuka J, Sheahan T, Adelman PC, Sypek EI, Fulton SA, Friedman RL, Wright MC, Duque MG, Lee YS, Hu Z, Huang H, Cai X, Gale JR, Nagarajan V, Hirai T, Meerschaert KA, Scherrer G, Kaplan DH, Porreca F, Davis BM, Gold MS, Koerber HR, Ross SE. Kappa Opioid Receptor Distribution and Function in Primary Afferents. Neuron. 2018 Sep 19;99(6):1274-1288.e6. doi: 10.1016/j.neuron.2018.08.044. PMID: 30236284

Hachisuka J, Omori Y, Chiang MC, Koerber HR, Ross SE. Wind-up in lamina I spinoparabrachial neurons: a role for reverberatory circuits. Pain. 2018 Mar 23.doi: 10.1097/j.pain.0000000000001229. PMID: 29578943

Hachisuka J, Chiang MC, Ross SE. Itch and Neuropathic Itch. Pain. 2018. Jan 2; doi: 10.1097/j.pain.0000000000001141. PMID: 29389746

Zhao Y, Sivaji S, Chiang MC, Cheng A, Haadi A, Guo Z, Reed A, Kodali R, Borowski J, Frost G, Beukema P, Wills ZP. Amyloid Beta Peptides Block New Synapse Assembly by Nogo Receptor Mediated Inhibition of T-Type Calcium Channels. Neuron. 2017. Oct 11;96(2):355-372.e6. doi: 10.1016/j.neuron.2017.09.041. PMID: 29024660.

Trainee Name: Alexis Chidi
Trainee: Past
Faculty Member: Bryce, Cindy L.
Publications:

Chidi AP, Bryce CL, Myaskovsky L, Fine MJ, Geller DA, Landsittel DP, Tsung A, 2015, Differences in Physician Referral Drive Disparities in Surgical Intervention for Hepatocellular Carcinoma: A Retrospective Cohort Study, Ann Surg. [Epub ahead of print]

Chidi AP, Rogal S, Bryce CL, Fine MJ, Good CB, Myaskovsky L, Rustgi VK, Tsung A, Smith KJ, 2015, Cost-Effectiveness of New Antiviral Regimens for Treatment-Naïve US Veterans with Hepatitis C, Hepatology.  [Epub ahead of print]

Dong ZM, Chidi AP, Goswami J, Han K, Simmons RL, Rosengart MR, Tsung A, 2015, Prior inpatient admission increases the risk of post-operative infection in hepatobiliary and pancreatic surgery, HPB (Oxford), 17(12):1105-12.

Tohme S, Goswami J, Han K, Chidi AP, Geller DA, Reddy S, Gleisner A, Tsung A, 2015, Minimally Invasive Resection of Colorectal Cancer Liver Metastases Leads to an Earlier Initiation of Chemotherapy Compared to Open Surgery, J Gastrointest Surg, 19(12):2199-206.

Tohme S, Varley PR, Landsittel DP, Chidi AP, Tsung A. Preoperative anemia and postoperative outcomes after hepatectomy. HPB (Oxford). 2016 Mar;18(3):255-61. doi: 10.1016/j.hpb.2015.09.002. Epub 2015 Nov 14. PMID: 27017165; PMCID: PMC4814609.

Tohme S, Chidi AP, Sud V, Tsung A. Prognostic Nutritional Index Is Associated with Survival in Patients with Unresectable Hepatocellular Carcinoma Treated with Radioembolization. J Vasc Interv Radiol. 2017 Mar;28(3):470-472. doi: 10.1016/j.jvir.2016.10.016. PMID: 28231927.

Varley PR, Tohme ST, Chidi AP, Goswami J, van der Windt D, Geller DA, Tsung A. Dissemination of Minimally Invasive Liver Resection for Primary Malignancy: Reevaluating Effectiveness. Ann Surg Oncol. 2018 Mar;25(3):808-817. doi: 10.1245/s10434-017-6308-2. Epub 2018 Jan 4. PMID: 29302818.

Chidi AP, Bryce CL, Donohue JM, Fine MJ, Landsittel DP, Myaskovsky L, Rogal SS, Switzer GE, Tsung A, Smith KJ. Economic and Public Health Impacts of Policies Restricting Access to Hepatitis C Treatment for Medicaid Patients. Value Health. 2016 Jun;19(4):326-34. 

Rogal SS, Arnold RM, Chapko M, Hanusa BV, Youk A, Switzer GE, Sevick MA, Bayliss NK, Zook CL, Chidi A, Obrosky DS, Zickmund SL. The Patient-Provider Relationship Is Associated with Hepatitis C Treatment Eligibility: A Prospective Mixed-Methods Cohort Study. PLoS One. 2016 Feb 22;11(2):e0148596. doi: 10.1371/journal.pone.0148596. PMID: 26900932; PMCID: PMC4763474.

Rogal SS, Udawatta V, Akpan I, Moghe A, Chidi A, Shetty A, Szigethy E, Bielefeldt K, DiMartini A. Risk factors for hospitalizations among patients with cirrhosis: A prospective cohort study. PLoS One. 2017 Nov 17;12(11):e0187176. doi: 10.1371/journal.pone.0187176. PMID: 29149171; PMCID: PMC5693413.

Trainee Name: Wai Chiu
Trainee: Past
Faculty Member: Palladino, Michael
Publications:

Celotto AM, Chiu WK, Van Voorhies W, Palladino MJ. Modes of metabolic compensation during mitochondrial disease using the Drosophila model of ATP6 dysfunction. PLoS One. 2011;6(10):e25823. doi: 10.1371/journal.pone.0025823. Epub 2011 Oct 3. PMID: 21991365; PMCID: PMC3185040.

Chiu WK, Towheed A, Palladino MJ. Genetically encoded redox sensors. Methods Enzymol. 2014;542:263-87. doi: 10.1016/B978-0-12-416618-9.00014-5. PMID: 24862271.

Chiu WK, Brand RM, Camp D, Edick S, Mitchell C, Karas S, Zehmisch A, Ho K, Brand RE, Harrison J, Abo S, Cranston RD, McGowan I. The Safety of Multiple Flexible Sigmoidoscopies with Mucosal Biopsies in Healthy Clinical Trial Participants. AIDS Res Hum Retroviruses. 2017 Aug;33(8):820-826. doi: 10.1089/aid.2016.0293. Epub 2017 Mar 15. PMID: 28296471; PMCID: PMC5564058.

Trainee Name: Serah Choi
Trainee: Past
Faculty Member: Bakkenist, Christopher J.
Publications:

White JS, Choi S, Bakkenist CJ, 2008, Irreversible chromosome damage accumulates rapidly in the absence of ATM kinase activity, Cell Cycle, 7(9):1277-84.

Goff JP, Shields DS, Seki M, Choi S, Epperly MW, Dixon T, Wang H, Bakkenist CJ, Dertinger SD, Torous DK, Wittschieben J, Wood RD, Greenberger JS, 2009, Lack of DNA polymerase theta (POLQ) radiosensitizes bone marrow stromal cells in vitro and increases reticulocyte micronuclei after total-body irradiation, Radiat Res, 172(2):165-74.

Momcilović O, Choi S, Varum S, Bakkenist C, Schatten G, Navara C, 2009, Ionizing radiation induces ataxia telangiectasia mutated-dependent checkpoint signaling and G(2) but not G(1) cell cycle arrest in pluripotent human embryonic stem cells, Stem Cells, 27(8):1822-35.

Choi S, Gamper AM, White JS, Bakkenist CJ, 2010, Inhibition of ATM kinase activity does not phenocopy ATM protein disruption: implications for the clinical utility of ATM kinase inhibitors, Cell Cycle, 9(20):4052-7.

Rajagopalan MS, Stone B, Rwigema JC, Salimi U, Epperly MW, Goff J, Franicola D, Dixon T, Cao S, Zhang X, Buchholz BM, Bauer AJ, Choi S, Bakkenist C, Wang H, Greenberger JS, 2010, Intraesophageal manganese superoxide dismutase-plasmid liposomes ameliorates novel total-body and thoracic radiation sensitivity of NOS1-/- mice, Radiat Res, 174(3):297-312.

White JS, Choi S, Bakkenist CJ, 2010, Transient ATM kinase inhibition disrupts DNA damage-induced sister chromatid exchange, Sci Signal, 3(124):ra44.

Bista RK, Uttam S, Wang P, Staton K, Choi S, Bakkenist CJ, Hartman DJ, Brand RE, Liu Y, 2011, Quantification of nanoscale nuclear refractive index changes during the cell cycle, J Biomed Opt, 16(7):070503.

Choi S, Toledo LI, Fernandez-Capetillo O, Bakkenist CJ, 2011, CGK733 does not inhibit ATM or ATR kinase activity in H460 human lung cancer cells, DNA Repair (Amst), 10(10):1000-1; author reply 1002.

Choi S, Srivas R, Fu KY, Hood BL, Dost B, Gibson GA, Watkins SC, Van Houten B, Bandeira N, Conrads TP, Ideker T, Bakkenist CJ, 2012, Quantitative proteomics reveal ATM kinase-dependent exchange in DNA damage response complexes, J Proteome Res, 11(10):4983-91.

Gamper AM, Choi S, Matsumoto Y, Banerjee D, Tomkinson AE, Bakkenist CJ, 2012, ATM protein physically and functionally interacts with proliferating cell nuclear antigen to regulate DNA synthesis, J Biol Chem, 287(15):12445-54.

Qian W, Choi S, Gibson GA, Watkins SC, Bakkenist CJ, Van Houten B, 2012, Mitochondrial hyperfusion induced by loss of the fission protein Drp1 causes ATM-dependent G2/M arrest and aneuploidy through DNA replication stress, J Cell Sci, 125(Pt 23):5745-57.

Choi S, Bakkenist CJ, 2013, Brd4 shields chromatin from ATM kinase signaling storms, Sci Signal, 6(293):pe30.

Uttam S, Bista RK, Staton K, Alexandrov S, Choi S, Bakkenist CJ, Hartman DJ, Brand RE, Liu Y, 2013, Investigation of depth-resolved nanoscale structural changes in regulated cell proliferation and chromatin decondensation, Biomed Opt Express, 4(4):596-613. Erratum: Oct 2013 Biomed Opt Express 4(11):2491.

Trainee Name: D. Won-Jae Chung
Trainee: Past
Faculty Member: Lewis, David
Publications:

Chung DW, Volk DW, Arion D, Zhang Y, Sampson AR, Lewis DA. Dysregulated ErbB4 Splicing in Schizophrenia: Selective Effects on Parvalbumin Expression. Am J Psychiatry. 2016 Jan;173(1):60-8.

Chung DW, Fish KN, Lewis DA. Pathological Basis for Deficient Excitatory Drive to Cortical Parvalbumin Interneurons in Schizophrenia. Am J Psychiatry. 2016 Nov 1;173(11):1131-1139.

Chung DW, Fish KN, Lewis DA. Pathological Basis for Deficient Excitatory Drive to Cortical Parvalbumin Interneurons in Schizophrenia. Am J Psychiatry. 2016 Nov 1;173(11):1131-1139.

Chung DW, Chung Y, Bazmi HH, Lewis DA. Altered ErbB4 splicing and cortical parvalbumin interneuron dysfunction in schizophrenia and mood disorders. Neuropsychopharmacology. 2018 Nov;43(12):2478-2486.

Trainee Name: Samuel Clanton
Trainee: Past
Faculty Member: Schwartz, Andrew
Publications:

Velliste M, McMorland AJ, Diril E, Clanton ST, Schwartz AB. State-space control of prosthetic hand shape. Annu Int Conf IEEE Eng Med Biol Soc. 2012;2012:964-7. doi: 10.1109/EMBC.2012.6346093. PMID: 23366054.

Collinger JL, Kryger MA, Barbara R, Betler T, Bowsher K, Brown EH, Clanton ST, Degenhart AD, Foldes ST, Gaunt RA, Gyulai FE, Harchick EA, Harrington D, Helder JB, Hemmes T, Johannes MS, Katyal KD, Ling GS, McMorland AJ, Palko K, Para MP, Scheuermann J, Schwartz AB, Skidmore ER, Solzbacher F, Srikameswaran AV, Swanson DP, Swetz S, Tyler-Kabara EC, Velliste M, Wang W, Weber DJ, Wodlinger B, Boninger ML. Collaborative approach in the development of high-performance brain-computer interfaces for a neuroprosthetic arm: translation from animal models to human control. Clin Transl Sci. 2014 Feb;7(1):52-9. doi: 10.1111/cts.12086. Epub 2013 Aug 27. PMID: 24528900; PMCID: PMC3929226.

Trainee Name: Elliot Collins, MD, PhD
Trainee: Past
Faculty Member: Behrmann, Marlene
Publications:

Collins, E., Behrmann, M. (2020). Exemplar Learning Reveals the Representational Origins of Expert Visual Perception. Proceedings of the National Academy of Sciences. 117(20), 11167-11177. DOI: https://doi.org/10.1073/pnas.1912734117. PMID: 32366664 PMCID: PMC7245133

Collins, E., Freud, E., Kainerstorfer, J.M., Cao, J., Behrmann, M. (2019). Temporal Dynamics of Shape Processing Differentiate Contributions of Dorsal and Ventral Visual Pathways. Journal of Cognitive Neuroscience, 31(6), 821-836. DOI: https://doi.org/10.1162/jocn_a_01391 

Collins, E., Robinson, A., Behrmann, M. (2018). Distinct Neural Processes for the Perception of Familiar Versus Unfamiliar Faces Along the Visual Hierarchy Revealed by EEG. NeuroImage, 181, 120-131. DOI: 10.1016/j.neuroimage.2018.06.080. PMCID: PMC6139062

Collins, E., Dundas, E., Gabay, Y., Plaut, D.C., Behrmann, M. (2017). Hemispheric Organization in Disorders of Development. Visual Cognition, 25(4-6): 416-429. DOI:10.1080/13506285.2017.1370430 PMCID: PMC6241318

Collins, E., Park, J., Behrmann, M. (2017). Numerosity Representation is Encoded in the Human Subcortex. Proceedings of the National Academy of Sciences, 114(14), E2806–E2815. DOI: 10.1073/pnas.1613982114. PMCID: PMC5389276

Trainee Name: Natasha Corbitt
Trainee: Past
Faculty Member: Demetris, Jake A
Publications:

Isse K, Grama K, Abbott IM, Lesniak A, Lunz JG, Lee WM, Specht S, Corbitt N, Mizuguchi Y, Roysam B, Demetris AJ. Adding value to liver (and allograft) biopsy evaluation using a combination of multiplex quantum dot immunostaining, high-resolution whole-slide digital imaging, and automated image analysis. Clin Liver Dis. 2010 Nov;14(4):669-85. doi: 10.1016/j.cld.2010.07.004. PMID: 21055689.

Mizuguchi Y, Isse K, Specht S, Lunz JG 3rd, Corbitt N, Takizawa T, Demetris AJ. Small proline rich protein 2a in benign and malignant liver disease. Hepatology. 2014 Mar;59(3):1130-43. doi: 10.1002/hep.26889. Epub 2014 Jan 27. PMID: 24123265.

Raimondi G, Sumpter TL, Matta BM, Pillai M, Corbitt N, Vodovotz Y, Wang Z, Thomson AW. Mammalian target of rapamycin inhibition and alloantigen-specific regulatory T cells synergize to promote long-term graft survival in immunocompetent recipients. J Immunol. 2010 Jan 15;184(2):624-36. doi: 10.4049/jimmunol.0900936. Epub 2009 Dec 9. PMID: 20007530; PMCID: PMC2923839.

Mizuguchi Y, Specht S, Lunz JG 3rd, Isse K, Corbitt N, Takizawa T, Demetris AJ. Cooperation of p300 and PCAF in the control of microRNA 200c/141 transcription and epithelial characteristics. PLoS One. 2012;7(2):e32449. doi: 10.1371/journal.pone.0032449. Epub 2012 Feb 22. PMID: 22384255; PMCID: PMC3284570.

Yan J, Hokey DA, Morrow MP, Corbitt N, Harris K, Harris D, Weiner DB. Novel SIVmac DNA vaccines encoding Env, Pol and Gag consensus proteins elicit strong cellular immune responses in cynomolgus macaques. Vaccine. 2009 May 26;27(25-26):3260-6. doi: 10.1016/j.vaccine.2009.01.065. Epub 2009 Feb 5. PMID: 19200811.

Corbitt N, Kimura S, Isse K, Specht S, Chedwick L, Rosborough BR, Lunz JG, Murase N, Yokota S, Demetris AJ. Gut bacteria drive Kupffer cell expansion via MAMP-mediated ICAM-1 induction on sinusoidal endothelium and influence preservation-reperfusion injury after orthotopic liver transplantation. Am J Pathol. 2013 Jan;182(1):180-91. doi: 10.1016/j.ajpath.2012.09.010. Epub 2012 Nov 14. PMID: 23159949; PMCID: PMC3532712.

Mizuguchi Y, Specht S, Lunz JG 3rd, Isse K, Corbitt N, Takizawa T, Demetris AJ. SPRR2A enhances p53 deacetylation through HDAC1 and down regulates p21 promoter activity. BMC Mol Biol. 2012 Jun 25;13:20. doi: 10.1186/1471-2199-13-20. PMID: 22731250; PMCID: PMC3495018.

Trainee Name: Christopher David
Trainee: Past
Faculty Member: Berman, Sarah B.
Publications:

Dukes AA, Bai Q, Van Laar VS, Zhou Y, Ilin V, David CN, Agim ZS, Bonkowsky JL, Cannon JR, Watkins SC, Croix CM, Burton EA, Berman SB. Live imaging of mitochondrial dynamics in CNS dopaminergic neurons in vivo demonstrates early reversal of mitochondrial transport following MPP(+) exposure. Neurobiol Dis. 2016;95:238-49. Epub 2016/07/28. doi: 10.1016/j.nbd.2016.07.020. PubMed PMID: 27452482; PMCID: PMC5010936.

Trainee Name: Patricia dela Cruz (Castillo), MD, PhD
Trainee: Past
Faculty Member: Kolls, Jay
Publications:

Kumar P, Monin L, Castillo P, Elsegeiny W, Horne W, Eddens T, Vikram A, Good M, Schoenborn AA, Bibby K, Montelaro RC, Metzger DW, Gulati AS, Kolls JK. Intestinal Interleukin-17 Receptor Signaling Mediates Reciprocal Control of the Gut Microbiota and Autoimmune Inflammation. Immunity. 2016 Mar 15;44(3):659-671. doi: 10.1016/j.immuni.2016.02.007. PMID: 26982366; PMCID: PMC4794750.

Castillo P, Kolls JK. IL-10: A Paradigm for Counterregulatory Cytokines. J Immunol. 2016 Sep 1;197(5):1529-30. doi: 10.4049/jimmunol.1601192. PMID: 27543665.

Eddens T, Elsegeiny W, Garcia-Hernadez ML, Castillo P, Trevejo-Nunez G, Serody K, Campfield BT, Khader SA, Chen K, Rangel-Moreno J, Kolls JK. Pneumocystis-Driven Inducible Bronchus-Associated Lymphoid Tissue Formation Requires Th2 and Th17 Immunity. Cell Rep. 2017 Mar 28;18(13):3078-3090. doi: 10.1016/j.celrep.2017.03.016. PMID: 28355561; PMCID: PMC5411079.

Elsegeiny W, Zheng M, Eddens T, Gallo RL, Dai G, Trevejo-Nunez G, Castillo P, Kracinovsky K, Cleveland H, Horne W, Franks J, Pociask D, Pilarski M, Alcorn JF, Chen K, Kolls JK. Murine models of Pneumocystis infection recapitulate human primary immune disorders. JCI Insight. 2018 Jun 21;3(12):e91894. doi: 10.1172/jci.insight.91894. PMID: 29925696; PMCID: PMC6124425.

Trevejo-Nunez G, Elsegeiny W, Aggor FEY, Tweedle JL, Kaplan Z, Gandhi P, Castillo P, Ferguson A, Alcorn JF, Chen K, Kolls JK, Gaffen SL. Interleukin-22 (IL-22) Binding Protein Constrains IL-22 Activity, Host Defense, and Oxidative Phosphorylation Genes during Pneumococcal Pneumonia. Infect Immun. 2019 Oct 18;87(11):e00550-19. doi: 10.1128/IAI.00550-19. PMID: 31451621; PMCID: PMC6803344.

Castillo-Dela Cruz P, Wanek AG, Kumar P, An X, Elsegeiny W, Horne W, Fitch A, Burr AHP, Gopalakrishna KP, Chen K, Methé BA, Canna SW, Hand TW, Kolls JK. Intestinal IL-17R Signaling Constrains IL-18-Driven Liver Inflammation by the Regulation of Microbiome-Derived Products. Cell Rep. 2019 Nov 19;29(8):2270-2283.e7. doi: 10.1016/j.celrep.2019.10.042. PMID: 31747600; PMCID: PMC6886715.

Castillo, P.A.C. & Hand, T.W. A little fiber goes a long way. Immunity. 2018, May; 48(5): 844-846.

Trainee Name: Sherrie Divito
Trainee: Past
Faculty Member: Morelli, Adrian
Publications:

Zhuang, Q., Q. Liu, S. J. Divito, Q. Zeng, K. M. Yatim, A. D. Hughes, D. M. Rojas-Canales, A. Nakao, W. J. Shufesky, A. L. Williams, R. Humar, R. A. Hoffman, W. D. Shlomchik, M. H. Oberbarnscheidt, F. G. Lakkis, and A. E. Morelli. 2016. Graft-infiltrating host dendritic cells play a key role in organ transplant rejection. Nat Commun 7:12623.

Liu, Q., D. M. Rojas-Canales, S. J. Divito, W. J. Shufesky, D. B. Stolz, G. Erdos, M. L. Sullivan, G. A. Gibson, S. C. Watkins, A. T. Larregina, and A. E. Morelli. 2016. Donor dendritic cell-derived exosomes promote allograft-targeting immune response. J Clin Invest 126:2805-2820.

Larregina, A. T., S. J. Divito, and A. E. Morelli. 2015. Clinical implications of basic science discoveries: nociceptive neurons as targets to control immunity--potential relevance for transplantation. Am J Transplant 15:1472-1474.

Perone, M. J., S. Bertera, W. J. Shufesky, S. J. Divito, A. Montecalvo, A. R. Mathers, A. T. Larregina, M. Pang, N. Seth, K. W. Wucherpfennig, M. Trucco, L. G. Baum, and A. E. Morelli. 2009. Suppression of autoimmune diabetes by soluble galectin-1. J Immunol 182:2641-2653.

Montecalvo, A., W. J. Shufesky, D. B. Stolz, M. G. Sullivan, Z. Wang, S. J. Divito, G. D. Papworth, S. C. Watkins, P. D. Robbins, A. T. Larregina, and A. E. Morelli. 2008. Exosomes as a short-range mechanism to spread alloantigen between dendritic cells during T cell allorecognition. J Immunol 180:3081-3090.

Wang, Z., Shufesky W.J., Montecalvo A., Divito S.J., Larregina A.T. and Morelli A.E. 2009. In situ-targeting of dendritic cells with donor-derived apoptotic cells restrains indirect allorecognition and ameliorates allograft vasculopathy. PLoS One 4:e4940.

Divito, S.J., A. Montecalvo, Z. Wang, W.J. Shufesky, G. Erdos, A.T. Larregina, and A.E. Morelli. 2010 Endogenous dendritic cells mediate the effects of intravenously injected therapeutic immunosuppressive dendritic cells in transplantation. Blood 116:2694-2705.

Divito S.J., Morelli A.E., and Larregina A.T. 2011 Role of neurokinin-1 receptor in the initiation and maintenance of skin chronic inflammatory diseases. Immunol. Res. 50:195-201.

Montecalvo A, AT Larregina, WJ Shufesky, D Beer Stolz, MLG Sullivan, JM Karlsson, CJ Baty, GA Gibson, G Erdos, Z Wang, J Milosevic, O Tkacheva, SJ Divito, R Jordan, J Lyons-Weiler, SC Watkins, and AE Morelli. 2012 Mechanism of transfer of functionalmicroRNAs between mouse dendritic cells via exosomes. Blood, 119:756-766.

Wang Z, Divito SJ, Shufesky WJ, Sumpter T, Wang H, Tkacheva OA, Wang W, Liu C, Larregina AT, and AE Morelli. 2012 Dendritic cell (DC) therapies in transplantation revisited: Deletion of conventional DCs deters the effect of therapeutic tolerogenic DCs. Am J Transplant, 12:1398-1408.

Larregina AT, Divito SJ, and Morelli AE. 2015 Nociceptive neurons as targets to control immunity: Potential relevance for transplantation. Am. J. Transplant., 15:1472-1474.

Divito S.J. and Morelli A.E. 2009 Apoptotic cells for therapy of transplant rejection. In: “Phagocytosis of dying cells: From molecular mechanism to human diseases”.  (Ed. D.V. Krysko and P. Vandernabeele). Springer. Chapter 11:319-346.

Trainee Name: Taylor Eddens
Trainee: Past
Faculty Member: Kolls, Jay
Publications:

Hebert KD, Mclaughlin N, Galeas-Pena M, Zhang Z, Eddens T, Govero A, Pilewski JM, Kolls JK, Pociask DA. Targeting the IL-22/IL-22BP axis enhances tight junctions and reduces inflammation during influenza infection. Mucosal Immunol. 2020 Jan;13(1):64-74. doi: 10.1038/s41385-019-0206-9. Epub 2019 Oct 9. PMID: 31597930; PMCID: PMC6917921.

Eddens T, Elsegeiny W, Ricks D, Goodwin M, Horne WT, Zheng M, Kolls JK. Transcriptomic and Proteomic Approaches to Finding Novel Diagnostic and Immunogenic Candidates in Pneumocystis. mSphere. 2019 Sep 4;4(5):e00488-19. doi: 10.1128/mSphere.00488-19. PMID: 31484742; PMCID: PMC6731532.

Elsegeiny W, Zheng M, Eddens T, Gallo RL, Dai G, Trevejo-Nunez G, Castillo P, Kracinovsky K, Cleveland H, Horne W, Franks J, Pociask D, Pilarski M, Alcorn JF, Chen K, Kolls JK. Murine models of Pneumocystis infection recapitulate human primary immune disorders. JCI Insight. 2018 Jun 21;3(12):e91894. doi: 10.1172/jci.insight.91894. PMID: 29925696; PMCID: PMC6124425.

Eddens T, Kaplan DJ, Anderson AJM, Nowalk AJ, Campfield BT. Insights From the Geographic Spread of the Lyme Disease Epidemic. Clin Infect Dis. 2019 Jan 18;68(3):426-434. doi: 10.1093/cid/ciy510. PMID: 29920580; PMCID: PMC6336907.

Campfield, B. T., Eddens T., Henkel M., Majewski M., Horne W., Chaly Y., Gaffen S. L., Hirsch R., Kolls J.K. 2017. Follistatin-like protein 1 modulates IL-17 signaling via IL-17RC regulation in stromal cells. Immunol Cell Biol. 2017.

Eddens T, Elsegeiny W, de la Luz Garcia-Hernadez M, et al. Pneumocystis driven inducible bronchus associated lymphoid tissue formation requires Th2 and Th17 immunity. Cell reports. 2017;18(13):3078-3090. doi:10.1016/j.celrep.2017.03.016.

Flitter BA, Hvorecny KL, Ono E, Eddens T, Yang J, Kwak DH, Bahl CD, Hampton TH, Morisseau C, Hammock BD, Liu X, Lee JS, Kolls JK, Levy BD, Madden DR, Bomberger JM. Pseudomonas aeruginosa sabotages the generation of host proresolving lipid mediators. Proc Natl Acad Sci U S A. 2017 Jan 3;114(1):136-141. doi: 10.1073/pnas.1610242114. Epub 2016 Dec 15. PMID: 27980032; PMCID: PMC5224368.

Chen K, Eddens T, Trevejo-Nunez G, Way EE, Elsegeiny W, Ricks DM, Garg AV, Erb CJ, Bo M, Wang T, Chen W, Lee JS, Gaffen SL, Kolls JK. IL-17 Receptor Signaling in the Lung Epithelium Is Required for Mucosal Chemokine Gradients and Pulmonary Host Defense against K. pneumoniae. Cell Host Microbe. 2016 Nov 9;20(5):596-605. doi: 10.1016/j.chom.2016.10.003. Epub 2016 Oct 27. PMID: 27923703; PMCID: PMC5149406.

Chen K, Campfield BT, Wenzel SE, McAleer JP, Kreindler JL, Kurland G, Gopal R, Wang T, Chen W, Eddens T, Quinn KM, Myerburg MM, Horne WT, Lora JM, Albrecht BK, Pilewski JM, Kolls JK. Antiinflammatory effects of bromodomain and extraterminal domain inhibition in cystic fibrosis lung inflammation. JCI Insight. 2016 Jul 21;1(11):e87168. doi: 10.1172/jci.insight.87168. PMID: 27517095; PMCID: PMC4978187.

Eddens T, Song E, Ardura MI, Kolls JK. A protracted course of Pneumocystis pneumonia in the setting of an immunosuppressed child with GMS-negative bronchoalveolar lavage. Med Mycol Case Rep. 2016 Apr 25;11:48-52. doi: 10.1016/j.mmcr.2016.04.004. PMID: 27182485; PMCID: PMC4857217.

Eddens T, Campfield BT, Serody K, Manni ML, Horne W, Elsegeiny W, McHugh KJ, Pociask D, Chen K, Zheng M, Alcorn JF, Wenzel S, Kolls JK. A Novel CD4+ T Cell-Dependent Murine Model of Pneumocystis-driven Asthma-like Pathology. Am J Respir Crit Care Med. 2016 Oct 1;194(7):807-820. doi: 10.1164/rccm.201511-2205OC. PMID: 27007260; PMCID: PMC5074654.

Kumar P, Monin L, Castillo P, Elsegeiny W, Horne W, Eddens T, Vikram A, Good M, Schoenborn AA, Bibby K, Montelaro RC, Metzger DW, Gulati AS, Kolls JK. Intestinal Interleukin-17 Receptor Signaling Mediates Reciprocal Control of the Gut Microbiota and Autoimmune Inflammation. Immunity. 2016 Mar 15;44(3):659-671. doi: 10.1016/j.immuni.2016.02.007. PMID: 26982366; PMCID: PMC4794750.

Zheng M, Horne W, McAleer JP, Pociask D, Eddens T, Good M, Gao B, Kolls JK. Therapeutic Role of Interleukin 22 in Experimental Intra-abdominal Klebsiella pneumoniae Infection in Mice. Infect Immun. 2016 Jan 4;84(3):782-9. doi: 10.1128/IAI.01268-15. PMID: 26729763; PMCID: PMC4771339.

Eddens T, Elsegeiny W, Nelson MP, Horne W, Campfield BT, Steele C, Kolls JK. Eosinophils Contribute to Early Clearance of Pneumocystis murina Infection. J Immunol. 2015 Jul 1;195(1):185-93. doi: 10.4049/jimmunol.1403162. Epub 2015 May 20. PMID: 25994969; PMCID: PMC4475669.

Elsegeiny W, Eddens T, Chen K, Kolls JK. Anti-CD20 antibody therapy and susceptibility to Pneumocystis pneumonia. Infect Immun. 2015 May;83(5):2043-52. doi: 10.1128/IAI.03099-14. Epub 2015 Mar 2. PMID: 25733518; PMCID: PMC4399075.

Eddens T, Kolls JK. Pathological and protective immunity to Pneumocystis infection. Semin Immunopathol. 2015 Mar;37(2):153-62. doi: 10.1007/s00281-014-0459-z. Epub 2014 Nov 25. PMID: 25420451; PMCID: PMC4329019.

Zheng M, Cai Y, Eddens T, Ricks DM, Kolls JK. Novel pneumocystis antigen discovery using fungal surface proteomics. Infect Immun. 2014 Jun;82(6):2417-23. doi: 10.1128/IAI.01678-13. Epub 2014 Mar 31. Erratum in: Infect Immun. 2014 Aug;82(8):3513. PMID: 24686066; PMCID: PMC4019171.

Eddens T, Kolls JK. Host defenses against bacterial lower respiratory tract infection. Curr Opin Immunol. 2012 Aug;24(4):424-30. doi: 10.1016/j.coi.2012.07.005. Epub 2012 Jul 25. PMID: 22841348; PMCID: PMC3971433.

Eddens T, Kolls JK. Pathological and protective immunity to Pneumocystis infection. Semin Immunopathol. 2015 Mar;37(2):153-62.

Trainee Name: Judson Englert
Trainee: Past
Faculty Member: Oury, Timothy
Publications:

Milutinovic PS, Englert JM, Crum LT, Mason NS, Ramsgaard L, Enghild JJ, Sparvero LJ, Lotze MT, Oury TD. Clearance kinetics and matrix binding partners of the receptor for advanced glycation end products. PLoS One. 2014 Mar 18;9(3):e88259. doi: 10.1371/journal.pone.0088259. PMID: 24642901; PMCID: PMC3958346.

Ramsgaard L, Englert JM, Tobolewski J, Tomai L, Fattman CL, Leme AS, Kaynar AM, Shapiro SD, Enghild JJ, Oury TD. The role of the receptor for advanced glycation end-products in a murine model of silicosis. PLoS One. 2010 Mar 19;5(3):e9604. doi: 10.1371/journal.pone.0009604. PMID: 20333255; PMCID: PMC2841632.

Milutinovic PS, Alcorn JF, Englert JM, Crum LT, Oury TD. The receptor for advanced glycation end products is a central mediator of asthma pathogenesis. Am J Pathol. 2012 Oct;181(4):1215-25. doi: 10.1016/j.ajpath.2012.06.031. Epub 2012 Aug 11. PMID: 22889845; PMCID: PMC3463633.

Ramsgaard L, Englert JM, Manni ML, Milutinovic PS, Gefter J, Tobolewski J, Crum L, Coudriet GM, Piganelli J, Zamora R, Vodovotz Y, Enghild JJ, Oury TD. Lack of the receptor for advanced glycation end-products attenuates E. coli pneumonia in mice. PLoS One. 2011;6(5):e20132. doi: 10.1371/journal.pone.0020132. Epub 2011 May 23. PMID: 21629785; PMCID: PMC3100338.

Englert JM, Kliment CR, Ramsgaard L, Milutinovic PS, Crum L, Tobolewski JM, Oury TD. Paradoxical function for the receptor for advanced glycation end products in mouse models of pulmonary fibrosis. Int J Clin Exp Pathol. 2011 Mar;4(3):241-54. Epub 2011 Mar 21. PMID: 21487520; PMCID: PMC3071657.

Englert JM, Hanford LE, Kaminski N, Tobolewski JM, Tan RJ, Fattman CL, Ramsgaard L, Richards TJ, Loutaev I, Nawroth PP, Kasper M, Bierhaus A, Oury TD. A role for the receptor for advanced glycation end products in idiopathic pulmonary fibrosis. Am J Pathol. 2008 Mar;172(3):583-91. doi: 10.2353/ajpath.2008.070569. Epub 2008 Feb 2. PMID: 18245812; PMCID: PMC2258251.

Englert JM, Ramsgaard L, Valnickova Z, Enghild JJ, Oury TD. Large scale isolation and purification of soluble RAGE from lung tissue. Protein Expr Purif. 2008 Sep;61(1):99-101. doi: 10.1016/j.pep.2008.05.004. Epub 2008 May 20. PMID: 18558495; PMCID: PMC2547992.

Kliment CR, Englert JM, Crum LP, Oury TD. A novel method for accurate collagen and biochemical assessment of pulmonary tissue utilizing one animal. Int J Clin Exp Pathol. 2011 Apr;4(4):349-55. Epub 2011 Apr 12. PMID: 21577320; PMCID: PMC3093059.

Kliment CR, Englert JM, Gochuico BR, Yu G, Kaminski N, Rosas I, Oury TD. Oxidative stress alters syndecan-1 distribution in lungs with pulmonary fibrosis. J Biol Chem. 2009 Feb 6;284(6):3537-45. doi: 10.1074/jbc.M807001200. Epub 2008 Dec 9. PMID: 19073610; PMCID: PMC2635035.

Trainee Name: Amir Faraji
Trainee: Past
Faculty Member: Weber, Stephen
Publications:

Faraji AH, Jaquins-Gerstl AS, Valenta AC, Ou Y, Weber SG. Electrokinetic Convection-Enhanced Delivery of Solutes to the Brain. ACS Chem Neurosci. 2020 Jul 15;11(14):2085-2093. doi: 10.1021/acschemneuro.0c00037. Epub 2020 Jul 6. PMID: 32559365.

Faraji AH, Jaquins-Gerstl AS, Valenta AC, Weber SG. Electrokinetic infusions into hydrogels and brain tissue: Control of direction and magnitude of solute delivery. J Neurosci Methods. 2019 Jan 1;311:76-82. doi: 10.1016/j.jneumeth.2018.10.005. Epub 2018 Oct 9. PMID: 30308210; PMCID: PMC6258323.

Guy Y, Faraji AH, Gavigan CA, Strein TG, Weber SG. Iontophoresis from a micropipet into a porous medium depends on the ζ-potential of the medium. Anal Chem. 2012 Mar 6;84(5):2179-87. doi: 10.1021/ac202434c. Epub 2012 Feb 17. PMID: 22264102; PMCID: PMC3312800.

Faraji AH, Cui JJ, Guy Y, Li L, Gavigan CA, Strein TG, Weber SG. Synthesis and characterization of a hydrogel with controllable electroosmosis: a potential brain tissue surrogate for electrokinetic transport. Langmuir. 2011 Nov 15;27(22):13635-42. doi: 10.1021/la202198k. Epub 2011 Oct 20. PMID: 21905710; PMCID: PMC3221612.

Trainee Name: Andrey Finegersh
Trainee: Past
Faculty Member: Homanics, Gregg E
Publications:

Finegersh A, Homanics GE. 2014, Paternal alcohol exposure reduces alcohol drinking and increases behavioral sensitivity to alcohol selectively in male offspring. PLoS One. 2014 Jun 4;9(6):e99078. doi: 10.1371/journal.pone.0099078. eCollection 2014. PMID: 24896617 PMCID: PMC4045990

Finegersh A, Homanics GE.2014, Acute ethanol alters multiple histone modifications at model gene promoters in the cerebral cortex. Alcohol Clin Exp Res. 2014 Jul;38(7):1865-73. doi: 10.1111/acer.12465. Epub 2014 Jun 18. PMID: 24942484 PMCID: PMC4107049

Finegersh A, Rompala GR, Martin DI, Homanics GE. 2015, Drinking beyond a lifetime: New and emerging insights into paternal alcohol exposure on subsequent generations. Alcohol. 2015 Aug;49(5):461-70. doi: 10.1016/j.alcohol.2015.02.008. Epub 2015 Mar 30. Review. PMID: 25887183 PMCID: PMC4469624

Finegersh A, Ferguson C, Maxwell S, Mazariegos D, Farrell D, Homanics GE. 2015, Repeated vapor ethanol exposure induces transient histone modifications in the brain that are modified by genotype and brain region. Front Mol Neurosci. 2015 Aug 5;8:39. doi: 10.3389/fnmol.2015.00039. eCollection 2015. PMID: 26300722 PMCID: PMC4524924

Finegersh A, Homanics GE. 2016, Chromatin immunoprecipitation and gene expression analysis of neuronal subtypes after fluorescence activated cell sorting. J Neurosci Methods. 2016 Apr 1;263:81-8. doi: 10.1016/j.jneumeth.2016.02.006. Epub 2016 Feb 8. PMID: 26868730 PMCID: PMC4801782

Rompala GR, Finegersh A, Homanics GE. 2016, Paternal preconception ethanol exposure blunts hypothalamic-pituitary-adrenal axis responsivity and stress-induced excessive fluid intake in male mice. Alcohol. 2016 Jun;53:19-25. doi: 10.1016/j.alcohol.2016.03.006. Epub 2016 Apr 22. PMID: 27286933 PMCID: PMC4904231

Trainee Name: Andrey Finegersh
Trainee: Past
Faculty Member: Homanics, Gregg
Publications:

Finegersh A, Rompala GR, Martin DI, Homanics GE. Drinking beyond a lifetime: New and emerging insights into paternal alcohol exposure on subsequent generations. Alcohol. 2015 Aug;49(5):461-70. doi: 10.1016/j.alcohol.2015.02.008. Epub 2015 Mar 30. PMID: 25887183; PMCID: PMC4469624.

Finegersh A, Homanics GE. Acute ethanol alters multiple histone modifications at model gene promoters in the cerebral cortex. Alcohol Clin Exp Res. 2014 Jul;38(7):1865-73. doi: 10.1111/acer.12465. Epub 2014 Jun 18. PMID: 24942484; PMCID: PMC4107049.

Rompala GR, Finegersh A, Slater M, Homanics GE. Paternal preconception alcohol exposure imparts intergenerational alcohol-related behaviors to male offspring on a pure C57BL/6J background. Alcohol. 2017 May;60:169-177. doi: 10.1016/j.alcohol.2016.11.001. Epub 2016 Nov 5. PMID: 27876231; PMCID: PMC5419883.

Rompala GR, Finegersh A, Homanics GE. Paternal preconception ethanol exposure blunts hypothalamic-pituitary-adrenal axis responsivity and stress-induced excessive fluid intake in male mice. Alcohol. 2016 Jun;53:19-25. doi: 10.1016/j.alcohol.2016.03.006. Epub 2016 Apr 22. PMID: 27286933; PMCID: PMC4904231.

Finegersh A, Homanics GE. Paternal alcohol exposure reduces alcohol drinking and increases behavioral sensitivity to alcohol selectively in male offspring. PLoS One. 2014 Jun 4;9(6):e99078. doi: 10.1371/journal.pone.0099078. PMID: 24896617; PMCID: PMC4045990.

Finegersh A, Ferguson C, Maxwell S, Mazariegos D, Farrell D, Homanics GE. Repeated vapor ethanol exposure induces transient histone modifications in the brain that are modified by genotype and brain region. Front Mol Neurosci. 2015 Aug 5;8:39. doi: 10.3389/fnmol.2015.00039. PMID: 26300722; PMCID: PMC4524924.

Finegersh A, Homanics GE. Chromatin immunoprecipitation and gene expression analysis of neuronal subtypes after fluorescence activated cell sorting. J Neurosci Methods. 2016 Apr 1;263:81-8. doi: 10.1016/j.jneumeth.2016.02.006. Epub 2016 Feb 8. PMID: 26868730; PMCID: PMC4801782.

Trainee Name: James Fisher
Trainee: Past
Faculty Member: Little, Steven R.
Publications:

Fisher, J. D., Acharya, A.P., Little, S.R., (2015) Micro and Nanoparticle Drug Delivery Systems for Preventing Allotransplant Rejections. (Clinical Immunology, 160: 24-35). PMID: 25937032.

Fisher, J.D., Zhang, W., Aral, A.M., Balmert, S.C., Kulahci, Y., Turnquist, H.R., Solari, M.G., Gorantla, V.S., Little, S.R. (2018) Biomimetic Microparticles Promote Survival of Vascularized Composite Allografts. (United States Department of Defense Report to the Executive Agent, FY17: 217-218).

Fisher, J.D., Zhang, W., Aral, A.M., Balmert, S.C., Kulahci, Y., Turnquist, H.R., Solari, M.G., Gorantla, V.S., Little, S.R. (2019) In situ recruitment of regulatory T cells promotes donor-specific tolerance in vascularized composite allotransplantation. (Science Advances, 13;6(11): eaax8429, DOI: 10.1126/sciadv.aax8429). PMID: 32201714

Fisher, J.D., Zhang, W., Balmert, S.C., Schweizer, R., Aral, A.M., Unadkat, J.V., Komatsu, C., Dong, L., Erubas, V., Schnider, J., Zhaoxiang, Z., Turnquist, H.R., Solari, M.G., Gorantla, V.S., Little, S.R. (2020) Treg Inducing Microparticles Promote Donor-Specific Tolerance in Experimental Vascularized Composite Allotransplantation. (Proceedings of the National Academy of Sciences, 116(51): 25784-25789). PMID: 31792185

Trainee Name: James Fisher
Trainee: Past
Faculty Member: Little, Steve
Publications:

Ginty AT, Kraynak TE, Fisher JP, Gianaros PJ. 2017. Cardiovascular and autonomic reactivity to psychological stress: Neurophysiological substrates and links to cardiovascular disease. Auton Neurosci. PMCID: PMC5600671

Fisher JD, Acharya AP, Little SR. Micro and nanoparticle drug delivery systems for preventing allotransplant rejection. Clin Immunol. 2015 Sep;160(1):24-35. doi: 10.1016/j.clim.2015.04.013. Epub 2015 May 1. PMID: 25937032; PMCID: PMC4554802.

DiLeo MV, Fisher JD, Burton BM, Federspiel WJ. Selective improvement of tumor necrosis factor capture in a cytokine hemoadsorption device using immobilized anti-tumor necrosis factor. J Biomed Mater Res B Appl Biomater. 2011 Jan;96(1):127-33. doi: 10.1002/jbm.b.31748. PMID: 21086427; PMCID: PMC3221482.

DiLeo MV, Fisher JD, Federspiel WJ. Experimental validation of a theoretical model of cytokine capture using a hemoadsorption device. Ann Biomed Eng. 2009 Nov;37(11):2310-6. doi: 10.1007/s10439-009-9780-4. Epub 2009 Aug 14. PMID: 19680812; PMCID: PMC2771882.

Trainee Name: Vanessa Franco (Chan)
Trainee: Past
Faculty Member: Turner, Robert
Publications:

Gardinier, J. Franco, V. and Schieber, M.H. Interactions between lateralized choices of hand and target Experimental Brain Research. 2006 Apr;170(2):149-159. PMID: 16328287

Franco, V. "Inducible Variations in Functional Connections Between M1 and Muscles." Journal of Undergraduate Research. University of Rochester. Spring 2006: 4(2): 15-20.

Davidson AG. , O'dell R, Chan V, Schieber MH et al. , Comparing effects in spike-triggered averages of rectified EMG across different behaviors. J Neurosci Methods, 2007. 163(2):283-94. PMID: 17477974

Davidson AG, Chan V, O'dell R, Schieber MH. "Rapid changes in throughput from single motor cortex neurons to muscle activity." Science. 2007 Dec 21 ; 318(5858):1934-7. PMID: 18096808

Chan V, Starr PA, Turner RS. "Bursts and oscillations as independent properties of neural activity in the parkinsonian Globus Pallidus internus." Neurobiol. Dis. 2010 Aug 18. PMID: 20727974.

Franco, V and Turner, RS. "Testing the Contributions of Striatal Dopamine Loss to the Genesis of Parkinsonian Signs." Accepted to Neurobiology of Disease, 2012 March.

Trainee Name: Lauren Frazer
Trainee: Past
Faculty Member: Darville, Toni
Publications:

Qu Y, Frazer LC, O'Connell CM, Tarantal AF, Andrews CW Jr, O'Connor SL, Russell AN, Sullivan JE, Poston TB, Vallejo AN, Darville T. Comparable Genital Tract Infection, Pathology, and Immunity in Rhesus Macaques Inoculated with Wild-Type or Plasmid-Deficient Chlamydia trachomatis Serovar D. Infect Immun. 2015 Oct;83(10):4056-67. doi: 10.1128/IAI.00841-15. Epub 2015 Jul 27. PMID: 26216426; PMCID: PMC4567646.

Frazer LC, Sullivan JE, Zurenski MA, Mintus M, Tomasak TE, Prantner D, Nagarajan UM, Darville T. CD4+ T cell expression of MyD88 is essential for normal resolution of Chlamydia muridarum genital tract infection. J Immunol. 2013 Oct 15;191(8):4269-79. doi: 10.4049/jimmunol.1301547. Epub 2013 Sep 13. PMID: 24038087; PMCID: PMC3796063.

Corr TE, Sullivan J, Frazer LC, Andrews CW Jr, O'Connell CM, Darville T. Steroids alone or as adjunctive therapy with doxycycline fail to improve oviduct damage in mice infected with Chlamydia muridarum. Clin Vaccine Immunol. 2014 Jun;21(6):824-30. doi: 10.1128/CVI.00006-14. Epub 2014 Apr 2. PMID: 24695778; PMCID: PMC4054235.

Russell AN, Zheng X, O'Connell CM, Wiesenfeld HC, Hillier SL, Taylor BD, Picard MD, Flechtner JB, Zhong W, Frazer LC, Darville T. Identification of Chlamydia trachomatis Antigens Recognized by T Cells From Highly Exposed Women Who Limit or Resist Genital Tract Infection. J Infect Dis. 2016 Dec 15;214(12):1884-1892. doi: 10.1093/infdis/jiw485. Epub 2016 Oct 12. PMID: 27738051; PMCID: PMC5142095.

Riley MM, Zurenski MA, Frazer LC, O'Connell CM, Andrews CW Jr, Mintus M, Darville T. The recall response induced by genital challenge with Chlamydia muridarum protects the oviduct from pathology but not from reinfection. Infect Immun. 2012 Jun;80(6):2194-203. doi: 10.1128/IAI.00169-12. Epub 2012 Mar 19. PMID: 22431649; PMCID: PMC3370586.

Frazer LC, O'Connell CM, Andrews CW Jr, Zurenski MA, Darville T. Enhanced neutrophil longevity and recruitment contribute to the severity of oviduct pathology during Chlamydia muridarum infection. Infect Immun. 2011 Oct;79(10):4029-41. doi: 10.1128/IAI.05535-11. Epub 2011 Aug 8. PMID: 21825059; PMCID: PMC3187238.

Barral R, Desai R, Zheng X, Frazer LC, Sucato GS, Haggerty CL, O'Connell CM, Zurenski MA, Darville T. Frequency of Chlamydia trachomatis-specific T cell interferon-γ and interleukin-17 responses in CD4-enriched peripheral blood mononuclear cells of sexually active adolescent females. J Reprod Immunol. 2014 Jun;103:29-37. doi: 10.1016/j.jri.2014.01.002. Epub 2014 Feb 1. PMID: 24582738; PMCID: PMC4505803.

Frazer LC, Darville T, Chandra-Kuntal K, Andrews CW Jr, Zurenski M, Mintus M, AbdelRahman YM, Belland RJ, Ingalls RR, O'Connell CM. Plasmid-cured Chlamydia caviae activates TLR2-dependent signaling and retains virulence in the guinea pig model of genital tract infection. PLoS One. 2012;7(1):e30747. doi: 10.1371/journal.pone.0030747. Epub 2012 Jan 24. PMID: 22292031; PMCID: PMC3265510.

Frazer LC, Scurlock AM, Zurenski MA, Riley MM, Mintus M, Pociask DA, Sullivan JE, Andrews CW Jr, Darville T. IL-23 induces IL-22 and IL-17 production in response to Chlamydia muridarum genital tract infection, but the absence of these cytokines does not influence disease pathogenesis. Am J Reprod Immunol. 2013 Dec;70(6):472-84. doi: 10.1111/aji.12171. PMID: 24238108; PMCID: PMC3852156.

Trainee Name: Matthew Geramita
Trainee: Past
Faculty Member: Urban, Nathan
Publications:

Wen J, Geramita M, Urban NN. Highly conserved deficits in sensory evoked responses in the olfactory bulb of two mouse models of autism. Submitted to eLife (2017).

Geramita M, Hofer J, Cooper J, Moritz ML. Decreased severity of Shiga toxin-producing Escherichia coli hemolytic uremic syndrome (STEC-HUS) in a child with Type 1 von Willebrand Disease. Submitted to Journal of Pediatrics (2017).

Geramita M, Urban NN. Differences in feed-forward inhibition on mitral and tufted cells lead to distinct modes of intensity coding. Journal of Neuroscience. 2017 Feb 8;37(6):1428-1438. PMID: 28028200.

Geramita EM, Herbeck Belnap B, Abebe KZ, Rothenberger SD, Rotondi AJ, Rollman BL. The Association Between Increased Levels of Patient Engagement With an Internet Support Group and Improved Mental Health Outcomes at 6-Month Follow-Up: Post-Hoc Analyses From a Randomized Controlled Trial. J Med Internet Res. 2018 Jul 17;20(7):e10402.

Trainee Name: Christin Glorioso
Trainee: Past
Faculty Member: Sibille, Etienne
Publications:

Glorioso CA, Pfenning AR, Lee SS, Bennett DA, Sibille EL, Kellis M, Guarente LP. Rate of brain aging and APOE ε4 are synergistic risk factors for Alzheimer's disease. Life Sci Alliance. 2019 May 27;2(3):e201900303. doi: 10.26508/lsa.201900303. PMID: 31133613; PMCID: PMC6537750.

Glorioso C, Sibille E. Between destiny and disease: genetics and molecular pathways of human central nervous system aging. Prog Neurobiol. 2011 Feb;93(2):165-81. doi: 10.1016/j.pneurobio.2010.11.006. Epub 2010 Dec 2. PMID: 21130140; PMCID: PMC3034779.

Glorioso C, Oh S, Douillard GG, Sibille E. Brain molecular aging, promotion of neurological disease and modulation by sirtuin 5 longevity gene polymorphism. Neurobiol Dis. 2011 Feb;41(2):279-90. doi: 10.1016/j.nbd.2010.09.016. Epub 2010 Sep 29. PMID: 20887790; PMCID: PMC3014380.

Sibille E, Su J, Leman S, Le Guisquet AM, Ibarguen-Vargas Y, Joeyen-Waldorf J, Glorioso C, Tseng GC, Pezzone M, Hen R, Belzung C. Lack of serotonin1B receptor expression leads to age-related motor dysfunction, early onset of brain molecular aging and reduced longevity. Mol Psychiatry. 2007 Nov;12(11):1042-56, 975. doi: 10.1038/sj.mp.4001990. Epub 2007 Apr 10. PMID: 17420766; PMCID: PMC2515886.

Glorioso C, Sabatini M, Unger T, Hashimoto T, Monteggia LM, Lewis DA, Mirnics K. Specificity and timing of neocortical transcriptome changes in response to BDNF gene ablation during embryogenesis or adulthood. Mol Psychiatry. 2006 Jul;11(7):633-48. doi: 10.1038/sj.mp.4001835. Epub 2006 May 9. PMID: 16702976.

Butters MA, Aizenstein HJ, Hayashi KM, Meltzer CC, Seaman J, Reynolds CF 3rd, Toga AW, Thompson PM, Becker JT; IMAGe Research Group. Three-dimensional surface mapping of the caudate nucleus in late-life depression. Am J Geriatr Psychiatry. 2009 Jan;17(1):4-12. doi: 10.1097/JGP.0b013e31816ff72b. PMID: 18790876; PMCID: PMC2970509.

Trainee Name: Rachael Gordon
Trainee: Past
Faculty Member: Shlomchik, Mark
Publications:

Tilstra JS, Avery L, Menk AV, Gordon RA, Smita S, Kane LP, Chikina M, Delgoffe GM, Shlomchik MJ. Kidney-infiltrating T cells in murine lupus nephritis are metabolically and functionally exhausted. J Clin Invest. 2018 Nov 1;128(11):4884-4897. doi: 10.1172/JCI120859. Epub 2018 Sep 24. PMID: 30130253; PMCID: PMC6205402.

Gordon RA, Herter JM, Rosetti F, Campbell AM, Nishi H, Kashgarian M, Bastacky SI, Marinov A, Nickerson KM, Mayadas TN, Shlomchik MJ. Lupus and proliferative nephritis are PAD4 independent in murine models. JCI Insight. 2017 May 18;2(10):e92926. doi: 10.1172/jci.insight.92926. PMID: 28515361; PMCID: PMC5436537.

Tilstra JS, John S, Gordon RA, Leibler C, Kashgarian M, Bastacky S, Nickerson KM, Shlomchik MJ. B cell-intrinsic TLR9 expression is protective in murine lupus. J Clin Invest. 2020 Jun 1;130(6):3172-3187. doi: 10.1172/JCI132328. PMID: 32191633; PMCID: PMC7260024.

Gordon RA, Tilstra JS, Marinov A, Nickerson KM, Bastacky SI, Shlomchik MJ. Murine lupus is neutrophil elastase-independent in the MRL.Faslpr model. PLoS One. 2020 Apr 3;15(4):e0226396. doi: 10.1371/journal.pone.0226396. PMID: 32243431; PMCID: PMC7122749.

Boiko JR, Anderson AJM, Gordon RA. Representation of Women Among Academic Grand Rounds Speakers. JAMA Intern Med. 2017 May 1;177(5):722-724. doi: 10.1001/jamainternmed.2016.9646. PMID: 28264094; PMCID: PMC5818773.

Tohme S, Yazdani HO, Al-Khafaji AB, Chidi AP, Loughran P, Mowen K, Wang Y, Simmons RL, Huang H, Tsung A. Neutrophil Extracellular Traps Promote the Development and Progression of Liver Metastases after Surgical Stress. Cancer Res. 2016 Mar 15;76(6):1367-80. doi: 10.1158/0008-5472.CAN-15-1591. Epub 2016 Jan 12. PMID: 26759232; PMCID: PMC4794393.

Trainee Name: Melanie Grubisha
Trainee: Past
Faculty Member: Defranco, Donald B.
Publications:

Wolf IM, Heitzer MD, Grubisha M, DeFranco DB. 2008, Coactivators and nuclear receptor transactivation. J Cell Biochem. 2008 Aug 1;104(5):1580-6. doi: 10.1002/jcb.21755. Review. PMID: 18393355

Wheeler DS, Barrick SR, Grubisha MJ, Brufsky AM, Friedman PA, Romero G. 2011, Direct interaction between NHERF1 and Frizzled regulates β-catenin signaling. Oncogene. 2011 Jan 6;30(1):32-42. doi: 10.1038/onc.2010.389. Epub 2010 Aug 30. PMID: 20802536 PMCID: PMC2995822

Grubisha MJ, Cifuentes ME, Hammes SR, Defranco DB. 2012, A local paracrine and endocrine network involving TGFβ, Cox-2, ROS, and estrogen receptor β influences reactive stromal cell regulation of prostate cancer cell motility. Mol Endocrinol. 2012 Jun;26(6):940-54. doi: 10.1210/me.2011-1371. Epub 2012 May 16. Erratum in: Mol Endocrinol. 2014 Feb;28(2):275. PMID: 22593181 PMCID: PMC3355541

Grubisha MJ, DeFranco DB. 2013, Local endocrine, paracrine and redox signaling networks impact estrogen and androgen crosstalk in the prostate cancer microenvironment. Steroids. 2013 Jun;78(6):538-41. doi: 10.1016/j.steroids.2013.01.005. Epub 2013 Feb 1. Review.PMID: 23380371 PMCID: PMC3644803

Leach DA, Need EF, Trotta AP, Grubisha MJ, DeFranco DB & Buchanan G. (2014). Hic-5 influences genomic and nongenomic actions of androgen receptor in prostate in myofibroblasts. Mol. Cell. Endocrinol. 384, 185-199 PMID: 24440747, PMCID in process

Liu TT, Grubisha MJ, Frahm KA, Wendell SG, Liu J, Ricke WA, Auchus RJ & DeFranco DB (2016). Opposing effects of cyclooxygenase-2 on estrogen receptor-ß response to 5- reductase inhibition in prostate epithelial cells. J. Biol. Chem. 291, 14747-14760. PMID 27226548, PMCID: PMC4938192

Trainee Name: Anoopum Gupta
Trainee: Past
Faculty Member: Touretzky, David
Publications:

Gupta AS, van der Meer MA, Touretzky DS, Redish AD (2012) Segmentation of spatial experience by hippocampal theta sequences. Nature Neuroscience 15(7):1032-1039. PMID: 22706269.

Gupta AS, van der Meer MA, Touretzky DS, Redish AD (2010) Hippocampal replay is not a simple function of experience. Neuron 65(5): 695-705. PMID: 20223204. *Previewed by Derdikman and Moser, Neuron 65(5):582-584. PMID: 20223195.

Trainee Name: Matthew Hedberg
Trainee: Past
Faculty Member: Grandis, Jennifer R.
Publications:

Lui VW, Hedberg ML, Li H, Vangara BS, Pendleton K, Zeng Y, Lu Y, Zhang Q, Du Y, Gilbert BR, Freilino M, Sauerwein S, Peyser ND, Xiao D, Diergaarde B, Wang L, Chiosea S, Seethala R, Johnson JT, Kim S, Duvvuri U, Ferris RL, Romkes M, Nukui T, Kwok-Shing Ng P, Garraway LA, Hammerman PS, Mills GB, Grandis JR, 2013, Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkers, Cancer Discov, 3(7):761-9.

Feng H, Lopez GY, Kim CK, Alvarez A, Duncan CG, Nishikawa R, Nagane M, Su AJ, Auron PE, Hedberg ML, Wang L, Raizer JJ, Kessler JA, Parsa AT, Gao WQ, Kim SH, Minata M, Nakano I, Grandis JR, McLendon RE, Bigner DD, Lin HK, Furnari FB, Cavenee WK, Hu B, Yan H, Cheng SY, 2014, EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis, J Clin Invest, 124(9):3741-56.

Hedberg ML, Goh G, Chiosea SI, Bauman JE, Freilino ML, Zeng Y, Wang L, Diergaarde BB, Gooding WE, Lui VW, Herbst RS, Lifton RP, Grandis JR, 2015, Genetic landscape of metastatic and recurrent head and neck squamous cell carcinoma, J Clin Invest. 2015 Nov 30. [Epub ahead of print]

Hedberg ML, Goh G, Chiosea SI, Bauman JE, Freilino ML, Zeng Y, Wang L, Diergaarde BB, Gooding WE, Lui VW, Herbst RS, Lifton RP, Grandis JR. Genetic landscape of metastatic and recurrent head and neck squamous cell carcinoma. J Clin Invest. 2016 Apr 1;126(4):1606. 

Geiger JL, Bauman JE, Gibson MK, Gooding WE, Varadarajan P, Kotsakis A, Martin D, Gutkind JS, Hedberg ML, Grandis JR, Argiris A. Phase II trial of everolimus in patients with previously treated recurrent or metastatic head and neck squamous cell carcinoma. Head Neck. 2016 Dec;38(12):1759-1764.

Li YY, Chung GT, Lui VW, To KF, Ma BB, Chow C, Woo JK, Yip KY, Seo J, Hui EP, Mak MK, Rusan M, Chau NG, Or YY, Law MH, Law PP, Liu ZW, Ngan HL, Hau PM, Verhoeft KR, Poon PH, Yoo SK, Shin JY, Lee SD, Lun SW, Jia L, Chan AW, Chan JY, Lai PB, Fung CY, Hung ST, Wang L, Chang AM, Chiosea SI, Hedberg ML, Tsao SW, van Hasselt AC, Chan AT, Grandis JR, Hammerman PS, Lo KW. Exome and genome sequencing of nasopharynx cancer identifies NF-κB pathway activating mutations. Nat Commun. 2017 Jan 18;8:14121.

Trainee Name: Niyathi Hegde-Shah
Trainee: Past
Faculty Member: Aizenman, Elias
Publications:

Shah, N.H. and E. Aizenman. 2013, Voltage-gated potassium channels at the crossroads of neuronal function, ischemic tolerance, and neurodegeneration. Transl Stroke Res. 2014 Feb;5(1):38-58. doi: 10.1007/s12975-013-0297-7. Epub 2013 Nov 19. PMID: 24323720 PMCID: PMC3946373

Shah, N.H., A.J. Schulien, K. Clemens, T.D. Aizenman, T.M. Hageman, Z.P. Wills and E. Aizenman. 2014, Cyclin E1 regulates Kv2.1 channel phosphorylation and localization in neuronal ischemia. J Neurosci. 2014 Mar 19;34(12):4326-31. doi: 10.1523/JNEUROSCI.5184-13.2014. PMID: 24647953 PMCID: PMC3960471

Schulien, A.J., J.A. Justice, R. Di Maio, Z.P. Wills, N.H. Shah and E. Aizenman. 2016, Zn(2+)-induced Ca(2+) release via ryanodine receptors triggers calcineurin-dependent redistribution of cortical neuronal Kv2.1 K(+) channels. J Physiol. 2016 May 15;594(10):2647-59. doi: 10.1113/JP272117. PMID: 26939666 PMCID: PMC4865584

Justice, J.A., A. J. Schulien, K. He, K.A. Hartnett, E. Aizenman and N.H. Shah. 2017, Disruption of Kv2.1 somato-dendritic clusters prevents the apoptogenic increase in potassium currents. Neuroscience. 2017 Jun 23;354:158-167. doi: 10.1016/j.neuroscience.2017.04.034. Epub 2017 Apr 28 PMID: 28461216 PMCID: PMC5709998

Trainee Name: G Hoftman
Trainee: Past
Faculty Member: Lewis, David
Publications:

Hoftman GD and Lewis DA: Postnatal developmental trajectories of neural circuits in the primate prefrontal cortex: Identifying sensitive periods for vulnerability to schizophrenia. Schizophr Bull 37:493-503, 2011.

Fish KN, Hoftman G, Sheikh W, Kitchens M, Lewis DA: Parvalbumin-containing chandelier and basket cell boutons have distinctive modes of maturation in monkey prefrontal cortex. J Neurosci 33:8352-8358, 2013.

Hoftman GD, Volk DW, Bazmi HH, Li S, Sampson AR, Lewis DA: Altered cortical expression of GABA-related genes in schizophrenia: Illness progression vs developmental disturbance. Schizophr Bull 41:180-191, 2015.

Hoftman G, Datta D, Lewis DA: Layer 3 excitatory and inhibitory circuitry in the prefrontal cortex: Developmental trajectories and alterations in schizophrenia. Biol Psychiatry 81:862-873, 2017.

Hoftman G, Dienel S, Bazmi H, Zhang Y, Chen K, Lewis DA: Altered gradients of glutamate and GABA transcripts in the cortical visuospatial working memory network in schizophrenia. Biol Psychiatry 83:670-679, 2018.

Dienel SJ, Enwright JF, Hoftman G, Lewis DA: Markers of glutamate and GABA neurotransmission in the prefrontal cortex of schizophrenia subjects: disease effects differ across anatomical levels of resolution. Schizophrenia Res 217:86-94, 2020.

Hoftman GD, Bazmi HH, Ciesielski AJ, Dinka LA, Chen K, Lewis DA: Postnatal development of glutamate and GABA transcript expression in monkey visual, parietal and prefrontal cortices. Cereb Cortex ePub December 7, 2020.

Trainee Name: Max Horowitz
Trainee: Past
Faculty Member: Greenamyre, Timothy
Publications:

Horowitz MP, Greenamyre JT. Mitochondrial iron metabolism and its role in neurodegeneration. J Alzheimers Dis. 2010;20 Suppl 2(Suppl 2):S551-68. doi: 10.3233/JAD-2010-100354. PMID: 20463401; PMCID: PMC3085540.

Horowitz MP, Milanese C, Di Maio R, Hu X, Montero LM, Sanders LH, Tapias V, Sepe S, van Cappellen WA, Burton EA, Greenamyre JT, Mastroberardino PG. Single-cell redox imaging demonstrates a distinctive response of dopaminergic neurons to oxidative insults. Antioxid Redox Signal. 2011 Aug 15;15(4):855-71. doi: 10.1089/ars.2010.3629. Epub 2011 Jun 6. PMID: 21395478; PMCID: PMC3135271.

Mastroberardino PG, Hoffman EK, Horowitz MP, Betarbet R, Taylor G, Cheng D, Na HM, Gutekunst CA, Gearing M, Trojanowski JQ, Anderson M, Chu CT, Peng J, Greenamyre JT. A novel transferrin/TfR2-mediated mitochondrial iron transport system is disrupted in Parkinson's disease. Neurobiol Dis. 2009 Jun;34(3):417-31. doi: 10.1016/j.nbd.2009.02.009. Epub 2009 Feb 26. PMID: 19250966; PMCID: PMC2784936.

Horowitz MP, Greenamyre JT. Gene-environment interactions in Parkinson's disease: the importance of animal modeling. Clin Pharmacol Ther. 2010 Oct;88(4):467-74. doi: 10.1038/clpt.2010.138. Epub 2010 Sep 1. PMID: 20811350; PMCID: PMC3085510.

Zharikov AD, Cannon JR, Tapias V, Bai Q, Horowitz MP, Shah V, El Ayadi A, Hastings TG, Greenamyre JT, Burton EA. shRNA targeting α-synuclein prevents neurodegeneration in a Parkinson's disease model. J Clin Invest. 2015 Jul 1;125(7):2721-35. doi: 10.1172/JCI64502. Epub 2015 Jun 15. PMID: 26075822; PMCID: PMC4563670.

Trainee Name: Uzoma Iheagwara
Trainee: Past
Faculty Member: Finn, Olivera
Publications:

Slater RC, Iheagwara U, Chen ML. Radiographical resolution of renal lymphangiomatosis following cardiac transplantation. Can J Urol. 2014 Apr;21(2):7248-50. PMID: 24775581.

Iheagwara UK, Beatty PL, Van PT, Ross TM, Minden JS, Finn OJ. Influenza virus infection elicits protective antibodies and T cells specific for host cell antigens also expressed as tumor-associated antigens: a new view of cancer immunosurveillance. Cancer Immunol Res. 2014 Mar;2(3):263-73. doi: 10.1158/2326-6066.CIR-13-0125. Epub 2013 Dec 5. PMID: 24778322; PMCID: PMC4006373.

Trainee Name: Soma Jobbagy
Trainee: Past
Faculty Member: Freeman, Bruce
Publications:

Jobbagy S, Tan RJ. Nitrolipids in kidney physiology and disease. Nitric Oxide. 2018 Mar 29. pii: S1089-8603(18)30006-5. doi: 10.1016/j.niox.2018.03.021. [Epub ahead of print] Review. PMID: 29605557

Villacorta L, Minarrieta L, Salvatore SR, Khoo NK, Rom O, Gao Z, Berman RC, Jobbagy S, Li L, Woodcock SR, Chen YE, Freeman BA, Ferreira AM, Schopfer FJ, Vitturi DA. In situ generation, metabolism and immunomodulatory signaling actions of nitro-conjugated linoleic acid in a murine model of inflammation. Redox Biol. 2018 May;15:522-531. doi: 10.1016/j.redox.2018.01.005. Epub 2018 Jan 12. PMID: 29413964; PMCID: PMC5881417.

Rahaman MM, Nguyen AT, Miller MP, Hahn SA, Sparacino-Watkins C, Jobbagy S, Carew NT, Cantu-Medellin N, Wood KC, Baty CJ, Schopfer FJ, Kelley EE, Gladwin MT, Martin E, Straub AC. 2017. Cytochrome b5 Reductase 3 Modulates Soluble Guanylate Cyclase Redox State and cGMP Signaling. Circ Res. 137-148. PMCID: PMC5527687.

Jobbagy S, Vitturi DA, Salvatore SR, Turell L, Pires MF, Kansanen E, Batthyany C, Lancaster JR Jr, Freeman BA, Schopfer FJ. Electrophiles modulate glutathione reductase activity via alkylation and upregulation of glutathione biosynthesis. Redox Biol. 2019 Feb;21:101050. doi: 10.1016/j.redox.2018.11.008. Epub 2018 Nov 22. PMID: 30654300; PMCID: PMC6348771.

Bonacci G, Baker PR, Salvatore SR, Shores D, Khoo NK, Koenitzer JR, Vitturi DA, Woodcock SR, Golin-Bisello F, Cole MP, Watkins S, St Croix C, Batthyany CI, Freeman BA, Schopfer FJ. Conjugated linoleic acid is a preferential substrate for fatty acid nitration. J Biol Chem. 2012 Dec 28;287(53):44071-82. doi: 10.1074/jbc.M112.401356. Epub 2012 Nov 9. PMID: 23144452; PMCID: PMC3531723.

Trainee Name: Colleen Judge-Golden, MD, PhD
Trainee: Past
Faculty Member: Sonya Borrero, MD
Publications:

Judge-Golden CP, Wiesenfeld HC, Chen BA, Borrero S. Adherence to Recommended Practices for Provision of Long-Acting Reversible Contraception Among Providers in a Large U.S. Health Care System. J Womens Health (Larchmt). 2020 Dec;29(12):1586-1595. doi: 10.1089/jwh.2019.8169. Epub 2020 Jul 13. PMID: 32667847; PMCID: PMC7757543.

Judge-Golden CP, Wolgemuth TE, Zhao X, Mor MK, Borrero S. Agreement between self-reported “ideal” and currently used contraceptive methods among women Veterans using the Veterans Affairs healthcare system. Women’s Health Issues. 2020 Jul; 30(4): 283-291. PMID: 32321666; PMC7347446

Quinn, D.A., Sileanu, F.E., Zhao, X., Mor, M.K., Judge-Golden, C., Callegari, L.S., & Borrero, S. (in press). History of unintended pregnancy and patterns of contraceptive use among racial and ethnic minority women Veterans. American Journal of Obstetrics & Gynecology. 2020 Oct;223(4):564.e1-564.e13. PMID: 32142832; PMC7528209

MacDonald S, Judge-Golden C, Borrero S, Zhao X, Mor MK, Hausmann LRM. Experiences of Perceived Gender-based Discrimination Among Women Veterans: Data From the ECUUN Study. Med Care. 2020 May;58(5):483-490. doi: 10.1097/MLR.0000000000001304. PMID: 32000171; PMCID: PMC7607520.

Arora KS, Zhao X, Judge-Golden C, Mor MK, Callegari LS, Borrero S. Factors Associated with Choice of Sterilization Among Women Veterans. J Womens Health (Larchmt). 2020 Jul;29(7):989-995. doi: 10.1089/jwh.2019.8036. Epub 2020 Feb 4. PMID: 32017866; PMCID: PMC7371549.

Britton LE, Judge-Golden CP, Wolgemuth TE, Zhao X, Mor MK, Callegari LS, Borrero S. Associations Between Perceived Susceptibility to Pregnancy and Contraceptive Use in a National Sample of Women Veterans. Perspect Sex Reprod Health. 2019 Dec;51(4):211-218. doi: 10.1363/psrh.12122. Epub 2019 Nov 20. PMID: 31749310; PMCID: PMC7147948.

Judge-Golden CP, Smith KJ, Mor MK, Borrero S. Financial Implications of 12-Month Dispensing of Oral Contraceptive Pills in the Veterans Affairs Health Care System. JAMA Intern Med. 2019 Jul 8;179(9):1201–8. doi: 10.1001/jamainternmed.2019.1678. Epub ahead of print. Erratum in: JAMA Intern Med. 2019 Aug 5;: PMID: 31282923; PMCID: PMC6618816.

Yecies EB, Judge-Golden CP, Callegari L, Borrero S. Contraceptive Care in the Veterans Health Administration. Semin Reprod Med. 2019 Jan;37(1):24-31. doi: 10.1055/s-0039-1692201. Epub 2019 Jun 11. PMID: 31185515; PMCID: PMC7047650.

Judge-Golden CP, Borrero S, Zhao X, Mor MK, Callegari LS. The Association between Mental Health Disorders and History of Unintended Pregnancy among Women Veterans. J Gen Intern Med. 2018 Dec;33(12):2092-2099. doi: 10.1007/s11606-018-4647-8. Epub 2018 Sep 5. PMID: 30187377; PMCID: PMC6258629.

Wolgemuth T, Judge-Golden C, Callegari L, Zhao X, Mor M, Borrero S. Associations between Pregnancy Intention, Attitudes, and Contraceptive Use among Women Veterans in the ECUUN Study. Womens Health Issues. 2018 Nov-Dec;28(6):480-487. doi: 10.1016/j.whi.2018.07.004. Epub 2018 Sep 18. PMID: 30241794; PMCID: PMC6215491.

Judge CP, Zhao X, Sileanu FE, Mor MK, Borrero S. Medical contraindications to estrogen and contraceptive use among women veterans. Am J Obstet Gynecol. 2018 Feb;218(2):234.e1-234.e9. doi: 10.1016/j.ajog.2017.10.020. Epub 2017 Oct 27. PMID: 29111146; PMCID: PMC5807130.

Judge CP, Wolgemuth TE, Hamm ME, Borrero S. "Without bodily autonomy we are not free": exploring women's concerns about future access to contraception following the 2016 US presidential election. Contraception. 2017 Nov;96(5):370-377. doi: 10.1016/j.contraception.2017.07.169. Epub 2017 Aug 8. PMID: 28801054; PMCID: PMC5643235.

Judge CP, Borrero S. Contraceptive decision making after the 2016 US presidential election. Am J Obstet Gynecol. 2017 Jul;217(1):89-90. doi: 10.1016/j.ajog.2017.03.025. Epub 2017 Mar 31. PMID: 28366732; PMCID: PMC5607639.

Trainee Name: Agnieszka Kalinowski
Trainee: Past
Faculty Member: Noel Dahl, Kris
Publications:

Dahl KN, Kalinowski A. Nucleoskeleton mechanics at a glance. J Cell Sci. 2011 Mar 1;124(Pt 5):675-8. doi: 10.1242/jcs.069096. PMID: 21321324; PMCID: PMC3039014.

Dahl KN, Kalinowski A, Pekkan K. Mechanobiology and the microcirculation: cellular, nuclear and fluid mechanics. Microcirculation. 2010 Apr;17(3):179-91. doi: 10.1111/j.1549-8719.2009.00016.x. PMID: 20374482; PMCID: PMC2881226.

Kalinowski A, Yaron PN, Qin Z, Shenoy S, Buehler MJ, Lösche M, Dahl KN. Interfacial binding and aggregation of lamin A tail domains associated with Hutchinson-Gilford progeria syndrome. Biophys Chem. 2014 Dec;195:43-8. doi: 10.1016/j.bpc.2014.08.005. Epub 2014 Aug 23. PMID: 25194277; PMCID: PMC4212650.

Ganesh S, Qin Z, Spagnol ST, Biegler MT, Coffey KA, Kalinowski A, Buehler MJ, Dahl KN. The tail domain of lamin B1 is more strongly modulated by divalent cations than lamin A. Nucleus. 2015;6(3):203-11. doi: 10.1080/19491034.2015.1031436. Epub 2015 Mar 25. PMID: 25807068; PMCID: PMC4615889.

Qin Z, Kalinowski A, Dahl KN, Buehler MJ. Structure and stability of the lamin A tail domain and HGPS mutant. J Struct Biol. 2011 Sep;175(3):425-33. doi: 10.1016/j.jsb.2011.05.015. Epub 2011 May 24. PMID: 21635954; PMCID: PMC3150306.

Kalinowski A, Qin Z, Coffey K, Kodali R, Buehler MJ, Lösche M, Dahl KN. Calcium causes a conformational change in lamin A tail domain that promotes farnesyl-mediated membrane association. Biophys J. 2013 May 21;104(10):2246-53. doi: 10.1016/j.bpj.2013.04.016. PMID: 23708364; PMCID: PMC3660631.

Choi S, Wang W, Ribeiro AJ, Kalinowski A, Gregg SQ, Opresko PL, Niedernhofer LJ, Rohde GK, Dahl KN. Computational image analysis of nuclear morphology associated with various nuclear-specific aging disorders. Nucleus. 2011 Nov-Dec;2(6):570-9. doi: 10.4161/nucl.2.6.17798. Epub 2011 Nov 1. PMID: 22127259; PMCID: PMC3324345.

Zhong Z, Chang SA, Kalinowski A, Wilson KL, Dahl KN. Stabilization of the spectrin-like domains of nesprin-1α by the evolutionarily conserved "adaptive" domain. Cell Mol Bioeng. 2010 Jun 1;3(2):139-150. doi: 10.1007/s12195-010-0121-3. PMID: 20563238; PMCID: PMC2885798.

Trainee Name: John Kang
Trainee: Past
Faculty Member: Schwartz, Russell
Publications:

J. Kang, R. Steward, R. Schwartz, P. R. Leduc, and K. Puskar.  “Controlled response of actin filament networks under cyclic stress through a coarse grained Monte Carlo model.” Journal of Theoretical Biology, 274:109-119, 2011.

J. Kang, KM Puskar, AJ Ehrlicher, PR LeDuc, and RS Schwartz. "Structurally governed cell mechanotransduction through multiscale modeling." Scientific Reports. 5, 2015.

Trainee Name: Liang Kang
Trainee: Past
Faculty Member: Mars, Wendy
Publications:

Isse K, Specht S, Lunz J, Kang L, Mizuguchi Y, Demetris A, 2010, Estrogen stimulates female biliary epithelial cell interleukin-6 expression in mice and humans, Hepatology (Baltimore, Md.), 51:869-80.

Lin C, Mars W, Paranjpe S, Donthamsetty S, Bhave V, Kang L, Orr A, Bowen W, Bell A, Michalopoulos G, 2011, Hepatocyte proliferation and hepatomegaly induced by phenobarbital and 1,4-bis [2-(3,5-dichloropyridyloxy)] benzene is suppressed in hepatocyte-targeted glypican 3 transgenic mice, Hepatology (Baltimore, Md.), 54:620-30.

Trainee Name: Heejae Kang, MD, PhD
Trainee: Past
Faculty Member: Peter Lucas, MD, PhD
Publications:

McAuley JR, Bailey KM, Ekambaram P, Kang H, Hu D, Freeman TJ, Klei LR, Concel VJ, Hubel NE, Sekar P, Bridwell RE, Covic L, Lucas PC#, and McAllister-Lucas LM# (2018) MALT1 is a critical mediator of PAR1-driven NF-κB activation and metastasis in multiple tumor types. Oncogene, 38:7384-7398

Cheng J, Klei LR, Hubel NE, Zhang M, Schairer R, Maurer LM, Klei HB, Kang, H, Concel VJ, Delekta PC, Dang EV, Mintz MA, Baens M, Cyster JG, Parameswaran N, Thome M, Lucas PC#, and McAllister-Lucas LM# (2020) GRK2 suppresses lymphomagenesis by inhibiting the MALT1 proto-oncoprotein. J. Clin. Invest., 130:1036-1051

Cheng J, Maurer LM, Kang H, Lucas PC, McAllister-Lucas LM. Critical protein-protein interactions within the CARMA1-BCL10-MALT1 complex: Take-home points for the cell biologist. Cell Immunol. 2020 Sep;355:104158. doi: 10.1016/j.cellimm.2020.104158. Epub 2020 Jul 7. PMID: 32721634.

Weick J, Kang H, Lee L, Kuether J, Liu X, Hansen E, Kandemir U, Rollins M, Mok J. Direct measurement of tissue oxygenation as a method of diagnosis of acute compartment syndrome. J Orthop Trauma. 2016 Nov;30(11):585-591.

Trainee Name: Neil Kelly
Trainee: Past
Faculty Member: Shapiro, Steven D
Publications:

Kelly NJ, Shapiro SD, 2014, PPARγ in emphysema: blunts the damage and triggers repair?, J Clin Invest, 124(3):978-80.

Tsuji T, Kelly NJ, Takahashi S, Leme AS, Houghton AM, Shapiro SD, 2014, Macrophage elastase suppresses white adipose tissue expansion with cigarette smoking, Am J Respir Cell Mol Biol, 51(6):822-9.

Kelly NJ, Dandachi N, Goncharov DA, Pena AZ, Radder JE, Gregory AD, Lai YC, Leme AS, Gladwin MT, Goncharova EA, St Croix CM, Shapiro SD. Automated Measurement of Blood Vessels in Tissues from Microscopy Images. Curr Protoc Cytom. 2016 Oct 10;78:12.44.1-12.44.13.

Kelly NJ, Radder JE, Baust JJ, Burton CL, Lai YC, Potoka KC, Agostini BA, Wood JP, Bachman TN, Vanderpool RR, Dandachi N, Leme AS, Gregory AD, Morris A, Mora AL, Gladwin MT, Shapiro SD. Mouse Genome-wide Association Study of Pre-clinical Group II Pulmonary Hypertension Identifies Egfr. Am J Respir Cell Mol Biol. 2017 Jan 13.

Meng Q, Lai YC, Kelly NJ, Bueno M, Baust J, Bachman T, Goncharov D, Vanderpool RR, Radder JE, Hu J, Goncharova E, Morris A, Mora AL, Shapiro SD, Gladwin MT. Development of a Mouse Model of Metabolic Syndrome, Pulmonary Hypertension, and Heart Failure with Preserved Ejection Fraction (PH-HFpEF). Am J Respir Cell Mol Biol. 2017 Jan 24.

Trainee Name: Alexander Kikuchi
Trainee: Past
Faculty Member: Monga, Satdarshan P.
Publications:

Kikuchi A, Pradhan-Sundd T, Singh S, Nagarajan S, Loizos N, Monga SP. 2017. Platelet-Derived Growth Factor Receptor α Contributes to Human Hepatic Stellate Cell Proliferation and Migration. Am J Pathol. 2273-2287. PMID: 28734947

Kikuchi A, Singh S, Poddar M, Nakao T, Schmidt HM, Gayden JD, Sato T, Arteel GE, Monga SP. Hepatic Stellate Cell-Specific Platelet-Derived Growth Factor Receptor-α Loss Reduces Fibrosis and Promotes Repair after Hepatocellular Injury. Am J Pathol. 2020 Oct;190(10):2080-2094. doi: 10.1016/j.ajpath.2020.06.006. Epub 2020 Jun 29. PMID: 32615075; PMCID: PMC7527859.

Kikuchi A, Monga SP. PDGFRα in liver pathophysiology: emerging roles in development, regeneration, fibrosis, and cancer. Gene Expr. 2015;16(3):109-27. doi: 10.3727/105221615X14181438356210. PMID: 25700367; PMCID: PMC4410163.

Zhang R, Kikuchi AT, Nakao T, Russell JO, Preziosi ME, Poddar M, Singh S, Bell AW, England SG, Monga SP. Elimination of Wnt Secretion From Stellate Cells Is Dispensable for Zonation and Development of Liver Fibrosis Following Hepatobiliary Injury. Gene Expr. 2019 Apr 18;19(2):121-136. doi: 10.3727/105221618X15373858350141. Epub 2018 Sep 20. PMID: 30236172; PMCID: PMC6466178.

Kikuchi A, Pradhan-Sundd T, Singh S, Nagarajan S, Loizos N, Monga SP. Platelet-Derived Growth Factor Receptor α Contributes to Human Hepatic Stellate Cell Proliferation and Migration. Am J Pathol. 2017 Oct;187(10):2273-2287. doi: 10.1016/j.ajpath.2017.06.009. Epub 2017 Jul 20. PMID: 28734947; PMCID: PMC5809633.

Zhou L, Pradhan-Sundd T, Poddar M, Singh S, Kikuchi A, Stolz DB, Shou W, Li Z, Nejak-Bowen KN, Monga SP. Mice with Hepatic Loss of the Desmosomal Protein γ-Catenin Are Prone to Cholestatic Injury and Chemical Carcinogenesis. Am J Pathol. 2015 Dec;185(12):3274-89. doi: 10.1016/j.ajpath.2015.08.019. Epub 2015 Oct 17. PMID: 26485505; PMCID: PMC4729235.

Nejak-Bowen K, Kikuchi A, Monga SP. Beta-catenin-NF-κB interactions in murine hepatocytes: a complex to die for. Hepatology. 2013 Feb;57(2):763-74. doi: 10.1002/hep.26042. Epub 2013 Jan 10. PMID: 22941935; PMCID: PMC3566301.

Trainee Name: Corrine Kliment
Trainee: Past
Faculty Member: Oury, Timothy
Publications:

Zheng M, Ramsay AJ, Robichaux MB, Kliment C, Crowe C, Rapaka RR, Steele C, McAllister F, Shellito JE, Marrero L, Schwarzenberger P, Zhong Q, Kolls JK. CD4+ T cell-independent DNA vaccination against opportunistic infections. JCI. 2005; 115(12):3536-44. PMID: 16308571 

Kliment CR, Tobolewski JM, Manni ML, Tan RJ, Enghild J, Oury TD. Extracellular superoxide dismutase protects against matrix degradation of heparan sulfate in the lung. Antioxidants & redox signaling. 2008; 10(2):261-8. PMID: 17961072 

Myllärniemi M, Lindholm P, Ryynänen MJ, Kliment CR, Salmenkivi K, Keski-Oja J, Kinnula VL, Oury TD, Koli K. Gremlin-mediated decrease in bone morphogenetic protein signaling promotes pulmonary fibrosis. American journal of respiratory and critical care medicine. 2008; 177(3):321-9. PMID: 17975199 

Carraway MS, Suliman HB, Kliment C, Welty-Wolf KE, Oury TD, Piantadosi CA. Mitochondrial biogenesis in the pulmonary vasculature during inhalational lung injury and fibrosis. Antioxidants & redox signaling. 2008; 10(2):269-75. PMID: 17999632 

Kliment CR, Clemens K, Oury TD. North american erionite-associated mesothelioma with pleural plaques and pulmonary fibrosis: a case report. International journal of clinical and experimental pathology. 2009; 2(4):407-10. PMID: 19158938 

Kliment CR, Englert JM, Gochuico BR, Yu G, Kaminski N, Rosas I, Oury TD. Oxidative stress alters syndecan-1 distribution in lungs with pulmonary fibrosis. JBC. 2009; 284(6):3537-45. PMID: 19073610 

Kliment CR, Suliman HB, Tobolewski JM, Reynolds CM, Day BJ, Zhu X, McTiernan CF, McGaffin KR, Piantadosi CA, Oury TD. Extracellular superoxide dismutase regulates cardiac function and fibrosis. Journal of molecular and cellular cardiology. 2009; 47(5):730-42. PMID: 19695260 

Houghton AM, Rzymkiewicz DM, Ji H, Gregory AD, Egea EE, Metz HE, Stolz DB, Land SR, Marconcini LA, Kliment CR, Jenkins KM, Beaulieu KA, Mouded M, Frank SJ, Wong KK, Shapiro SD. Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth. Nature medicine. 2010; 16(2):219-23. PMID: 20081861

Kliment CR, Oury TD. Oxidative stress, extracellular matrix targets, and idiopathic pulmonary fibrosis.  Free radical biology & medicine. 2010;49(5):707-17. PMID: 20452419 

Englert JM, Kliment CR, Ramsgaard L, Milutinovic PS, Crum L, Tobolewski JM, Oury TD. Paradoxical function for the receptor for advanced glycation end products in mouse models of pulmonary fibrosis. Int J Clin Exp Pathol. 2011; 4(3):241-54. PMID: 21487520 

Kliment CR, Englert JM, Crum LP, Oury TD. A novel method for accurate collagen and biochemical assessment of pulmonary tissue utilizing one animal. International journal of clinical and experimental pathology. 2011; 4(4):349-55. PMID: 21577320 

Kliment CR, Oury TD. Extracellular superoxide dismutase protects cardiovascular syndecan-1 from oxidative shedding. Free radical biology & medicine. 2011; 50(9):1075-80. PMID: 21334435 

Gregory AD*, Kliment CR*, Metz HE, Kim KH, Kargl J, Agostini BA, Crum LT, Oczypok EA, Oury TA, Houghton AM. Neutrophil elastase promotes myofibroblast differentiation in lung fibrosis. Journal of leukocyte biology. 2015; 98(2):143-52. PMID: 25743626 (*Authors contributed equally to the work)

Trainee Name: Jeffrey Koenitzer
Trainee: Past
Faculty Member: Freeman, Bruce
Publications:

Vitturi DA, Chen CS, Woodcock SR, Salvatore SR, Bonacci G, Koenitzer JR, Stewart NA, Wakabayashi N, Kensler TW, Freeman BA, Schopfer FJ. Modulation of nitro-fatty acid signaling: prostaglandin reductase-1 is a nitroalkene reductase. J Biol Chem. 2013 Aug 30;288(35):25626-37. doi: 10.1074/jbc.M113.486282. Epub 2013 Jul 22. PMID: 23878198; PMCID: PMC3757223.

Salvatore SR, Vitturi DA, Baker PR, Bonacci G, Koenitzer JR, Woodcock SR, Freeman BA, Schopfer FJ. Characterization and quantification of endogenous fatty acid nitroalkene metabolites in human urine. J Lipid Res. 2013 Jul;54(7):1998-2009. doi: 10.1194/jlr.M037804. Epub 2013 Apr 25. PMID: 23620137; PMCID: PMC3679401.

Koenitzer JR, Freeman BA. Redox signaling in inflammation: interactions of endogenous electrophiles and mitochondria in cardiovascular disease. Ann N Y Acad Sci. 2010 Aug;1203:45-52. doi: 10.1111/j.1749-6632.2010.05559.x. PMID: 20716282; PMCID: PMC4106461.

Trainee Name: Jared Kopelman, MD, PhD
Trainee: Past
Faculty Member: Susanne Ahmari, MD, PhD
Publications:

Zike ID, Chohan MO, Kopelman JM, Krasnow E, Flicker D, Nautiyal KM, Bubser M, Kellendonk C, Jones CK, Stanwood G, Tanaka K, Moore H, Ahmari SE, Veenstra-VanderWeele J. 2017. OCD candidate gene SLC1A1/EAAT3 impacts basal ganglia-mediated activity and stereotypic behavior. Proc Natl Acad Sci USA. 5719-5724. PMCID: PMC5465902.

Trainee Name: Shinjini Kundu
Trainee: Past
Faculty Member: Rohde, Gustavo
Publications:

Bonfield CM, Foley LM, Kundu S, Fellows-Mayle W, Hitchens TK, Rohde GK, Grandhi R, Mooney MP. The influence of surgical correction on white matter microstructural integrity in rabbits with familial coronal suture craniosynostosis. Neurosurg Focus. 2015 May;38(5):E3. doi: 10.3171/2015.2.FOCUS14849. PMID: 25929965; PMCID: PMC5347148.

SR Park, S Kolouri, S Kundu, GK Rohde, 2015, The Cumulative Distribution Transform and Linear Pattern Classification, arXiv preprint arXiv:1507.05936.

Kundu S, Kolouri S, Erickson KI, Kramer AF, McAuley E, Rohde GK. Discovery and visualization of structural biomarkers from MRI using transport-based morphometry. Neuroimage. 2018;167:256-75. Epub 2017/11/09. doi: 10.1016/j.neuroimage.2017.11.006. PubMed PMID: 29117580; PMCID: PMC5912801.

Kundu S, Ghodadra A, Fakhran S, Alhilali LM, Rohde GK. Assessing Postconcussive Reaction Time Using Transport-Based Morphometry of Diffusion Tensor Images. AJNR Am J Neuroradiol. 2019;40(7):1117-23. Epub 2019/06/15. doi: 10.3174/ajnr.A6087. PubMed PMID: 31196860; PMCID: PMC7048545.

Kundu S, Ashinsky BG, Bouhrara M, Dam EB, Demehri S, Shifat ERM, Spencer RG, Urish KL, Rohde GK. Enabling early detection of osteoarthritis from presymptomatic cartilage texture maps via transport-based learning. Proc Natl Acad Sci U S A. 2020;117(40):24709-19. Epub 2020/09/23. doi: 10.1073/pnas.1917405117. PubMed PMID: 32958644; PMCID: PMC7547154    

Kundu S, Alhilali L, Nguyen L, Fakhran S. Angioglioma misdiagnosed as encephalomalacia on magnetic resonance imaging for over a decade. J Comput Assist Tomogr. 2014 May-Jun;38(3):485-7. doi: 10.1097/RCT.0000000000000043. PMID: 24651748.

Trainee Name: Johannes Kutten
Trainee: Past
Faculty Member: Isenberg, Jeffrey
Publications:

Rogers NM, Sharifi-Sanjani M, Yao M, Ghimire K, Bienes-Martinez R, Mutchler SM, Knupp HE, Baust J, Novelli EM, Ross M, St Croix C, Kutten JC, Czajka CA, Sembrat JC, Rojas M, Labrousse-Arias D, Bachman TN, Vanderpool RR, Zuckerbraun BS, Champion HC, Mora AL, Straub AC, Bilonick RA, Calzada MJ, Isenberg JS. 2017. TSP1-CD47 signaling is upregulated in clinical pulmonary hypertension and contributes to pulmonary arterial vasculopathy and dysfunction. Oxford Academic. 15-29. PMCID: PMC5220673

Kutten JC, McGovern D, Hobson CM, Luffy SA, Nieponice A, Tobita K, Francis RJ, Reynolds SD, Isenberg JS, Gilbert TW, 2015, Decellularized tracheal extracellular matrix supports epithelial migration, differentiation, and function, Tissue Eng Part A, 21(1-2):75-84.

Trainee Name: Andrew Lamade, MD, PhD
Trainee: Past
Faculty Member: Hulya Bayir, MD
Publications:

Anthonymuthu TS, Kenny EM, Lamade AM, Gidwani H, Krehel NM, Misse A, Gao X, Amoscato AA, Straub AC, Kagan VE, Dezfulian C, Bayir H. Lipidomics Detection of Brain Cardiolipins in Plasma Is Associated With Outcome After Cardiac Arrest. Crit Care Med. 2019;47(4):e292-e300. Epub 2019/03/12. doi: 10.1097/CCM.0000000000003636. PubMed PMID: 30855329; PMCID: PMC6622168.

Anthonymuthu TS, Kenny EM, Lamade AM, Kagan VE, Bayir H. Oxidized phospholipid signaling in traumatic brain injury. Free Radic Biol Med. 2018;124:493-503. Epub 2018/07/03. doi: 10.1016/j.freeradbiomed.2018.06.031. PubMed PMID: 29964171; PMCID: PMC6098726.

Bayir H, Anthonymuthu TS, Tyurina YY, Patel SJ, Amoscato AA, Lamade AM, Yang Q, Vladimirov GK, Philpott CC, Kagan VE. Achieving Life through Death: Redox Biology of Lipid Peroxidation in Ferroptosis. Cell Chem Biol. 2020;27(4):387-408. Epub 2020/04/11. doi: 10.1016/j.chembiol.2020.03.014. PubMed PMID: 32275865; PMCID: PMC7218794.

Dezfulian C, Kenny E, Lamade A, Misse A, Krehel N, St Croix C, Kelley EE, Jackson TC, Uray T, Rackley J, Kochanek PM, Clark RS, Bayir H. Mechanistic characterization of nitrite-mediated neuroprotection after experimental cardiac arrest. J Neurochem. 2016;139(3):419-31. Epub 2016/10/25. doi: 10.1111/jnc.13764. PubMed PMID: 27507435; PMCID: PMC5247267.

Krainz T, Lamade AM, Du L, Maskrey TS, Calderon MJ, Watkins SC, Epperly MW, Greenberger JS, Bayir H, Wipf P, Clark RSB. Synthesis and Evaluation of a Mitochondria-Targeting Poly(ADP-ribose) Polymerase-1 Inhibitor. ACS Chem Biol. 2018;13(10):2868-79. Epub 2018/09/06. doi: 10.1021/acschembio.8b00423. PubMed PMID: 30184433; PMCID: PMC6402482.

Lamade AM, Anthonymuthu TS, Hier ZE, Gao Y, Kagan VE, Bayir H. Mitochondrial damage & lipid signaling in traumatic brain injury. Exp Neurol. 2020;329:113307. Epub 2020/04/15. doi: 10.1016/j.expneurol.2020.113307. PubMed PMID: 32289317; PMCID: PMC7237325.

Lamade AM, Kenny EM, Anthonymuthu TS, Soysal E, Clark RSB, Kagan VE, Bayir H. Aiming for the target: Mitochondrial drug delivery in traumatic brain injury. Neuropharmacology. 2019;145(Pt B):209-19. Epub 2018/07/17. doi: 10.1016/j.neuropharm.2018.07.014. PubMed PMID: 30009835; PMCID: PMC6309489.

Trainee Name: Mark Langhans
Trainee: Past
Faculty Member: Tuan, Rocky S.
Publications:

Langhans MT, Yu S, Tuan RS. Stem Cells in Skeletal Tissue Engineering: Technologies and Models. Curr Stem Cell Res Ther. 2016;11(6):453-474. doi: 0.2174/1574888x10666151001115248. PMID: 26423296; PMCID: PMC5543935.

Lin H, Sohn J, Shen H, Langhans MT, Tuan RS. Bone marrow mesenchymal stem cells: Aging and tissue engineering applications to enhance bone healing. Biomaterials. 2019 May;203:96-110. doi: 10.1016/j.biomaterials.2018.06.026. Epub 2018 Jun 22. PMID: 29980291; PMCID: PMC6733253.

Trainee Name: Hannah Lee
Trainee: Past
Faculty Member: Chu, Constance
Publications:

Lee HH, O'Malley MJ, Friel NA, Chu CR. Effects of doxycycline on mesenchymal stem cell chondrogenesis and cartilage repair. Osteoarthritis Cartilage. 2013 Feb;21(2):385-393. doi: 10.1016/j.joca.2012.11.010. Epub 2012 Nov 24. PMID: 23186943; PMCID: PMC5395099.

Lee HH, Chu CR. Clinical and Basic Science of Cartilage Injury and Arthritis in the Football (Soccer) Athlete. Cartilage. 2012 Jan;3(1 Suppl):63S-8S. doi: 10.1177/1947603511426882. PMID: 26069610; PMCID: PMC4297167.

Lee HH, O'Malley MJ, Friel NA, Payne KA, Qiao C, Xiao X, Chu CR. Persistence, localization, and external control of transgene expression after single injection of adeno-associated virus into injured joints. Hum Gene Ther. 2013 Apr;24(4):457-66. doi: 10.1089/hum.2012.118. PMID: 23496155; PMCID: PMC3631018.

Lee HH, Haleem AM, Yao V, Li J, Xiao X, Chu CR. Release of bioactive adeno-associated virus from fibrin scaffolds: effects of fibrin glue concentrations. Tissue Eng Part A. 2011 Aug;17(15-16):1969-78. doi: 10.1089/ten.TEA.2010.0586. Epub 2011 May 11. PMID: 21449684; PMCID: PMC3142631.

Lee HH, Imbriglia JE, Balk ML. Delayed mid-substance flexor tendon graft rupture 31 years after a two-stage reconstruction. J Hand Surg Eur Vol. 2019 Mar;44(3):325-326. doi: 10.1177/1753193418813627. Epub 2018 Nov 29. PMID: 30497319.

Trainee Name: Michael Leibowitz
Trainee: Past
Faculty Member: Ferris, Robert
Publications:

Davidson HC, Leibowitz MS, Lopez-Albaitero A, Ferris RL. Immunotherapy for head and neck cancer. Oral Oncol. 2009 Sep;45(9):747-51. doi: 10.1016/j.oraloncology.2009.02.009. Epub 2009 May 12. PMID: 19442565.

Leibowitz MS, Ferris RL. Recurrence in head and neck squamous cell carcinoma. Editorial. Cancer. 2008 Aug 15;113(4):671-3. doi: 10.1002/cncr.23616. PMID: 18536028.

Leibowitz MS, Nayak JV, Ferris RL. Head and neck cancer immunotherapy: clinical evaluation. Curr Oncol Rep. 2008 Mar;10(2):162-9. doi: 10.1007/s11912-008-0025-8. PMID: 18377830.

Leibowitz MS, Srivastava RM, Andrade Filho PA, Egloff AM, Wang L, Seethala RR, Ferrone S, Ferris RL. SHP2 is overexpressed and inhibits pSTAT1-mediated APM component expression, T-cell attracting chemokine secretion, and CTL recognition in head and neck cancer cells. Clin Cancer Res. 2013 Feb 15;19(4):798-808. doi: 10.1158/1078-0432.CCR-12-1517. Epub 2013 Jan 30. PMID: 23363816; PMCID: PMC3578140.

Leibowitz MS, Andrade Filho PA, Ferrone S, Ferris RL. Deficiency of activated STAT1 in head and neck cancer cells mediates TAP1-dependent escape from cytotoxic T lymphocytes. Cancer Immunol Immunother. 2011 Apr;60(4):525-35. doi: 10.1007/s00262-010-0961-7. Epub 2011 Jan 5. PMID: 21207025; PMCID: PMC3426276.

Sen M, Tosca PJ, Zwayer C, Ryan MJ, Johnson JD, Knostman KA, Giclas PC, Peggins JO, Tomaszewski JE, McMurray TP, Li C, Leibowitz MS, Ferris RL, Gooding WE, Thomas SM, Johnson DE, Grandis JR. Lack of toxicity of a STAT3 decoy oligonucleotide. Cancer Chemother Pharmacol. 2009 May;63(6):983-95. doi: 10.1007/s00280-008-0823-6. Epub 2008 Sep 3. PMID: 18766340; PMCID: PMC3422883.

Wesa AK, Herrem CJ, Mandic M, Taylor JL, Vasquez C, Kawabe M, Tatsumi T, Leibowitz MS, Finke JH, Bukowski RM, Bruckheimer E, Kinch MS, Storkus WJ. Enhancement in specific CD8+ T cell recognition of EphA2+ tumors in vitro and in vivo after treatment with ligand agonists. J Immunol. 2008 Dec 1;181(11):7721-7. doi: 10.4049/jimmunol.181.11.7721. PMID: 19017961; PMCID: PMC3427921.

Trainee Name: Kevin Levine
Trainee: Past
Faculty Member: Oesterreich, Steffi
Publications:

Sikora MJ, Jacobsen BM, Levine K, Chen J, Davidson NE, Lee AV, Alexander CM, Oesterreich S 2016, WNT4 mediates estrogen receptor signaling and endocrine resistance in invasive lobular carcinoma cell lines. Breast Cancer Res. 2016 Sep 20;18(1):92 PMID: 27650553 PMCID: PMC5028957

Bahreini A, Levine K, Santana-Santos L, Benos PV, Wang P, Andersen C, Oesterreich S, Lee AV. 2016, Non-coding single nucleotide variants affecting estrogen receptor binding and activity. Genome Med. 2016 Dec 13;8(1):128. PMID: 27964748 PMCID: PMC5154163

Hopkins BL, Nadler M, Skoko JJ, Bertomeu T, Pelosi A, Mousavi Shafaei P, Levine K, Schempf A, Pennarun B, Yang B, Datta D, Oesterreich S, Yang D, Rozzi M, Khosravi-Far R, Neumann CA. 2017, A Peroxidase Peroxiredoxin 1-Specific Redox Regulation of the Novel FOXO3 microRNA Target let-7. Antioxid Redox Signal. 2017 May 1;28(1):62–77. PMID: 28398822 PMCID: PMC5695745

Bahreini A, Li Z, Wang P, Levine KM, Tasdemir N, Cao L, Weir HM, Puhalla SL, Davidson NE, Stern AM, Chu D, Park BH, Lee AV, Oesterreich S. 2017, Mutation site and context dependent effects of ESR1 mutation in genome-edited breast cancer cell models. Breast Cancer Res. 2017 May 23;19(1):60. PMID: 28535794 PMCID: PMC5442865

Chen L, Vasilatos SN, Qin Y, Katz TA, Cao C, Wu H, Tasdemir N, Levine KM, Oesterreich S, Davidson NE, Huang Y. 2017, Functional characterization of lysine-specific demethylase 2 (LSD2/KDM1B) in breast cancer progression Oncotarget. 2017 Jul 19;8(47): PMID: 29137219 PMCID: PMC5669845

Li Z, Levine KM, Bahreini A, Wang P, Chu D, Park BH, Oesterreich S, Lee AV. 2018, Upregulation of IRS1 Enhances IGF1 Response in Y537S and ESR1 Mutant Breast Cancer Cells Endocrinology. 2018 Ja PMID: 29029116 PMCID: PMC5761602

Trainee Name: Jean Lin,
Trainee: Past
Faculty Member: Kane, Lawrence P.
Publications:

Su, E.W., Lin, J.Y., Kane, L.P., 2008, TIM-1 and TIM-3 Proteins in Immune Regulation, Cytokine, 44(2):9-13, PMID: 18706830 PMCID: PMC2574986

Lin J.Y. and Kane L.P., 2011, Are TIM proteins involved in asthma development or pathology?, Clin Exp Immunol. Review PMID: 21623966 PMCID: PMC3181465.

Lin J.Y.,, Chen L., and Kane LP., 2012, Murine Tim-1 is excluded from the immunological synapse, F1000 Research 1:10. PMID: 24627760 PMCID: PMC3938182

Trainee Name: Yuzhe (Brian) Liu
Trainee: Past
Faculty Member: Gopalakrishnan, Vanathi
Publications:

Liu Y, Gopalakrishnan V. An Overview and Evaluation of Recent Machine Learning Imputation Methods Using Cardiac Imaging Data. Data (Basel). 2017 Mar;2(1):8. doi: 10.3390/data2010008. Epub 2017 Jan 25. PMID: 28243594; PMCID: PMC5325161.

Liu Y, Manners J, Bittar Y, Chou SH, Gopalakrishnan V. Towards precision critical care management of blood pressure in hemorrhagic stroke patients using dynamic linear models. PLoS One. 2019 Aug 5;14(8):e0220283. doi: 10.1371/journal.pone.0220283. PMID: 31381589; PMCID: PMC6681940.

Trainee Name: Ricardo Londono
Trainee: Past
Faculty Member: Badylak, Stephen F.
Publications:

Londono R, Tighe S, Milnes B, DeMoya C, Quijano LM, Hudnall ML, Nguyen J, Tran E, Badylak S, Lozito TP. Single Cell Sequencing Analysis of Lizard Phagocytic Cell Populations and Their Role in Tail Regeneration. J Immunol Regen Med. 2020 Jun;8:100029. doi: 10.1016/j.regen.2020.100029. Epub 2020 Feb 19. PMID: 32337387; PMCID: PMC7182306.

Pineda Molina C, Hussey GS, Eriksson J, Shulock MA, Cárdenas Bonilla LL, Giglio RM, Gandhi RM, Sicari BM, Wang D, Londono R, Faulk DM, Turner NJ, Badylak SF. 4-Hydroxybutyrate Promotes Endogenous Antimicrobial Peptide Expression in Macrophages. Tissue Eng Part A. 2019 May;25(9-10):693-706. doi: 10.1089/ten.TEA.2018.0377. PMID: 30982430.

Sun AX, Londono R, Hudnall ML, Tuan RS, Lozito TP. Differences in neural stem cell identity and differentiation capacity drive divergent regenerative outcomes in lizards and salamanders. Proc Natl Acad Sci U S A. 2018 Aug 28;115(35):E8256-E8265. doi: 10.1073/pnas.1803780115. Epub 2018 Aug 13. PMID: 30104374; PMCID: PMC6126763.

Londono R, Sun AX, Tuan RS, Lozito TP. TISSUE REPAIR AND EPIMORPHIC REGENERATION: AN OVERVIEW. Curr Pathobiol Rep. 2018 Mar;6(1):61-69. doi: 10.1007/s40139-018-0161-2. Epub 2018 Feb 4. PMID: 29967714; PMCID: PMC6025457.

Londono R, Wenzhong W, Wang B, Tuan RS, Lozito TP. Cartilage and Muscle Cell Fate and Origins during Lizard Tail Regeneration. Front Bioeng Biotechnol. 2017 Nov 2;5:70. doi: 10.3389/fbioe.2017.00070. PMID: 29164111; PMCID: PMC5673626.

Dziki JL, Giglio RM, Sicari BM, Wang DS, Gandhi RM, Londono R, Dearth CL, Badylak SF. The Effect of Mechanical Loading Upon Extracellular Matrix Bioscaffold-Mediated Skeletal Muscle Remodeling. Tissue Eng Part A. 2018 Jan;24(1-2):34-46. doi: 10.1089/ten.TEA.2017.0011. Epub 2017 Apr 19. PMID: 28345417; PMCID: PMC6426277.

Costa A, Naranjo JD, Londono R, Badylak SF. Biologic Scaffolds. Cold Spring Harb Perspect Med. 2017 Sep 1;7(9):a025676. doi: 10.1101/cshperspect.a025676. PMID: 28320826; PMCID: PMC5580515.

Londono R, Dziki JL, Haljasmaa E, Turner NJ, Leifer CA, Badylak SF. The effect of cell debris within biologic scaffolds upon the macrophage response. J Biomed Mater Res A. 2017 Aug;105(8):2109-2118. doi: 10.1002/jbm.a.36055. Epub 2017 Apr 12. PMID: 28263432.

Costa A, Naranjo JD, Turner NJ, Swinehart IT, Kolich BD, Shaffiey SA, Londono R, Keane TJ, Reing JE, Johnson SA, Badylak SF. Mechanical strength vs. degradation of a biologically-derived surgical mesh over time in a rodent full thickness abdominal wall defect. Biomaterials. 2016 Nov;108:81-90. doi: 10.1016/j.biomaterials.2016.08.053. Epub 2016 Sep 2. PMID: 27619242.

Londono R, Gorantla VS, Badylak SF. Emerging Implications for Extracellular Matrix-Based Technologies in Vascularized Composite Allotransplantation. Stem Cells Int. 2016;2016:1541823. doi: 10.1155/2016/1541823. Epub 2015 Dec 29. PMID: 26839554; PMCID: PMC4709778.

Dearth CL, Slivka PF, Stewart SA, Keane TJ, Tay JK, Londono R, Goh Q, Pizza FX, Badylak SF. Inhibition of COX1/2 alters the host response and reduces ECM scaffold mediated constructive tissue remodeling in a rodent model of skeletal muscle injury. Acta Biomater. 2016 Feb;31:50-60. doi: 10.1016/j.actbio.2015.11.043. Epub 2015 Dec 2. PMID: 26612417; PMCID: PMC4728713.

Sicari BM , Londono R , Badylak SF . Strategies for skeletal muscle tissue engineering: seed vs. soil. J Mater Chem B. 2015 Oct 28;3(40):7881-7895. doi: 10.1039/c5tb01714a. Epub 2015 Sep 17. PMID: 32262901.

Keane TJ, Dziki J, Castelton A, Faulk DM, Messerschmidt V, Londono R, Reing JE, Velankar SS, Badylak SF. Preparation and characterization of a biologic scaffold and hydrogel derived from colonic mucosa. J Biomed Mater Res B Appl Biomater. 2017 Feb;105(2):291-306. doi: 10.1002/jbm.b.33556. Epub 2015 Oct 27. PMID: 26506408.

Keane TJ, DeWard A, Londono R, Saldin LT, Castleton AA, Carey L, Nieponice A, Lagasse E, Badylak SF. Tissue-Specific Effects of Esophageal Extracellular Matrix. Tissue Eng Part A. 2015 Sep;21(17-18):2293-300. doi: 10.1089/ten.TEA.2015.0322. PMID: 26192009; PMCID: PMC4556088.

Zaidi AH, Saldin LT, Kelly LA, Bergal L, Londono R, Kosovec JE, Komatsu Y, Kasi PM, Shetty AA, Keane TJ, Thakkar SJ, Huleihel L, Landreneau RJ, Badylak SF, Jobe BA. MicroRNA signature characterizes primary tumors that metastasize in an esophageal adenocarcinoma rat model. PLoS One. 2015 Mar 31;10(3):e0122375. doi: 10.1371/journal.pone.0122375. PMID: 25826212; PMCID: PMC4380408.

Londono R, Badylak SF. Regenerative Medicine Strategies for Esophageal Repair. Tissue Eng Part B Rev. 2015 Aug;21(4):393-410. doi: 10.1089/ten.TEB.2015.0014. Epub 2015 Apr 30. PMID: 25813694; PMCID: PMC4533024.

Londono R, Badylak SF. Biologic scaffolds for regenerative medicine: mechanisms of in vivo remodeling. Ann Biomed Eng. 2015 Mar;43(3):577-92. doi: 10.1007/s10439-014-1103-8. Epub 2014 Sep 12. PMID: 25213186.

Faulk DM, Londono R, Wolf MT, Ranallo CA, Carruthers CA, Wildemann JD, Dearth CL, Badylak SF. ECM hydrogel coating mitigates the chronic inflammatory response to polypropylene mesh. Biomaterials. 2014 Oct;35(30):8585-95. doi: 10.1016/j.biomaterials.2014.06.057. Epub 2014 Jul 16. PMID: 25043571; PMCID: PMC5942585.

Carey LE, Dearth CL, Johnson SA, Londono R, Medberry CJ, Daly KA, Badylak SF. In vivo degradation of 14C-labeled porcine dermis biologic scaffold. Biomaterials. 2014 Sep;35(29):8297-304. doi: 10.1016/j.biomaterials.2014.06.015. Epub 2014 Jul 3. PMID: 24997479; PMCID: PMC5372693.

Turner NJ, Londono R, Dearth CL, Culiat CT, Badylak SF. Human NELL1 protein augments constructive tissue remodeling with biologic scaffolds. Cells Tissues Organs. 2013;198(4):249-65. doi: 10.1159/000356491. Epub 2013 Dec 7. PMID: 24335144.

Londono R, Badylak SF. Biomaterials from Decellularized Tissues. Biomaterials from Decellularized Tissues. Natural Biomaterials for Advanced Devices and Therapies. Nuno M. Neves and Rui L. Reis (eds).

Sicari BM, Londono R, Badylak SF. Extracellular Matrix as a Bioscaffold for Tissue Engineering. In Tissue Engineering 2nd Edition. van Blitterswijk C.(eds.) Elsevier, San Diego, CA. 2015. pp. 149-176.

Scarritt M, Londono R, Badylak SF. Host Response to Implanted Materials and Devices: An Overview. In Immune Response to Implanted Materials and Devices: Host Response and Immunomodulation (ed.) Corradetti B. Springer Nature, Cham, Switzerland. 2016. pp 1-14.

Tottey S, Corselli M, Jeffries EM, Londono R, Peault B, Badylak SF. Extracellular matrix degradation products and low-oxygen conditions enhance the regenerative potential of perivascular stem cells. Tissue Eng Part A, 2011. 17 (1-2): 37-44. PMID: 20653348. PMCID: PMC3011908.

Keane TJ, Londono R, Turner NJ, Badylak SF. Consequences of ineffective decellularization of biologic scaffolds on the host response. Biomaterials, 2012. 33 (6): 1771-1781. PMID: 22137126. PMCID: NA.

Brown BN, Londono R, Tottey S, Zhang L, Kukla KA, Wolf MT, Daly KA, Reing JE, Badylak SF. Macrophage phenotype as a predictor of constructive remodeling following the implantation of biologically derived surgical mesh materials. Acta Biomater, 2012. 8 (3): 978-987. PMID: 22166681. PMCID: PMC4325370. NIHMSID: 346364

Londono R, Jobe BA, Hoppo T, Badylak SF. Esophagus and regenerative medicine. World J Gastroenterol. 2012. 18(47):6894-9. 23322986. PMCID: 3531672.

Nieponice A, Ciotola FF, Nachman F, Jobe BA, Hoppo T, Londono R, Badylak S, Badaloni AE. Patch esophagoplasty: esophageal reconstruction using biologic scaffolds. Ann Thorac Surg. 2014. 97(1):283-8. PMID: 24266951.

Sicari BM, Zhang L, Londono R, Badylak SF. An Assay to Quantify Chemotactic Properties of Degradation Products from Extracellular Matrix. Methods Mol Biol. 2013. 1202: 103-110. PMID: 24155230. PMCID: PMC4317790.

Faulk DM, Londono R, Wolf MT, Ranallo CA, Carruthers CA, Wildemann JD, Dearth CL, Badylak SF. ECM hydrogel coating mitigates the chronic inflammatory response to polypropylene mesh. Biomaterials. 2014. 35(30):8585-95. PMID: 25043571. PMCID: PMC5942585.

Londono R, Gorantla V, Badylak SF. Emerging Implications for Extracellular Matrix-Based Technologies in Vascularized Composite Allotransplantation. Stem Cells International, Vol. 2016, Article ID 1541823, 16 pages, 2016. doi:10.1155/2016/1541823. PMID: 26839554. PMCID: PMC4709778.

Zhu Y, Hideyoshi S, Jiang H, Matsumura Y, Dziki JL, LoPresti ST, Huleihel L, Faria GNF, Fuhrman LC, Lodono R, Badylak SF, Wagner WR. Injectable, porous, biohybrid hydrogels incorporating decellularized tissue components for soft tissue applications. Acta Biomater. 2018 Jun;73:112-126. PubMed PMID: 29649634; PubMed Central PMCID: PMC5985206.

Pineda Molina C, Giglio R, Gandhi RM, Sicari BM, Londono R, Hussey G, Bartolacci J, Dziki J, Badylak SF. Comparison of the host macrophage response to synthetic, bioresorbable, and biologic surgical meshes used for ventral hernia repair. Journal of Immunology and Regenerative Medicine. 2019;3:13-25. DOI:10.1016/J.REGEN.2018.12.002.

Saldin LT, Klimak M, Hill RC, Cramer MC, Huleihel L, Li X, Quidley-Martin, M, Cardenas D, Keane TJ, Londono R, Hussey GS, Kelly L, Kosovec JE, Lloyd EJ, Omstead AN, Zhang L, Nieponice A, Jobe B, Hansen K, Zaidi AH, Badylak SF. The effect of normal, metaplastic, and neoplastic esophageal extracellular matrix upon macrophage activation. Journal of Immunology and Regenerative Medicine 2020. DOI: https://doi.org/10.1016/j.regen.2020.100037.

Trainee Name: Maria Ly, MD, PhD
Trainee: Past
Faculty Member: Howard Aizenstein, PhD
Publications:

Ly, M., Foley, L., Manivannan, A., Hitchens, K.T., Richardson, R.M., Modo, M. Mesoscale diffusion magnetic resonance imaging of the ex vivo human hippocampus(2020). Human Brain Mapping.Cover illustration.

Lin, C.*, Ly, M.*, Karim, H.T., Wei, W., Snitz, B.E., Klunk, W.E., Aizenstein, H.J. The longitudinal effect of amyloid on the resting-state functional connectivity in cognitively normal older adults (2020) Alzheimer’s Research & Therapy.12(1): 1-10.*co-first authors.

Ly, M.,Yu, G.Z., Muppidi, N.R., Karim, H.T., Mizuno, A., Klunk, W.E., Aizenstein, H.J. for the Alzheimer’s Disease Neuroimaging Initiative. Improving Brain Age Prediction Models: Incorporation of Amyloid Status in Alzheimer’s Disease (2020) Neurobiology of Aging.87: 44-48.

Raji CA, Ly M, Benzinger TLS. Overview of MR Imaging Volumetric Quantification in Neurocognitive Disorders. Top Magn Reson Imaging. 2019 Dec;28(6):311-315. doi: 10.1097/RMR.0000000000000224. PMID: 31794503.

Wu M, Mennin DS, Ly M, Karim HT, Banihashemi L, Tudorascu DL, Aizenstein HJ, Andreescu C. When worry may be good for you: Worry severity and limbic-prefrontal functional connectivity in late-life generalized anxiety disorder. J Affect Disord. 2019 Oct 1;257:650-657. doi: 10.1016/j.jad.2019.07.022. Epub 2019 Jul 5. PMID: 31357162; PMCID: PMC6711791.

Mizuno A, Ly M, Aizenstein HJ. A Homeostatic Model of Subjective Cognitive Decline. Brain Sci. 2018 Dec 19;8(12):228. doi: 10.3390/brainsci8120228. PMID: 30572628; PMCID: PMC6316074.

Ly M, Andreescu C. Advances and Barriers for Clinical Neuroimaging in Late-Life Mood and Anxiety Disorders. Curr Psychiatry Rep. 2018 Mar 1;20(1):7. doi: 10.1007/s11920-018-0870-6. PMID: 29492705.

Mizuno, A., Karim, H.T., Rangarajan, A., Ly, M., Cohen, A.D., Lopresti, B.J., Mathis, C.A., Klunk, W.E., Aizenstein, H.J., Snitz, B.E. An effect of education on memory-encoding activation in subjective cognitive decline (2021). Journal of Alzheimer’s Disease.


Ly, M.*, Raji, C.A.*, Yu, G., Wang, Q., Wang, Y., Schindler, S., An, H., Samara, A., Eisenstein, S.A., Hershey, T., Smith, G., Klein, S., Ances, B., Morris, J.C., Benzinger, T.L. Obesity and White Matter Neuroinflammation Related Edema in Alzheimer’s Disease Biomarker Negative Cognitively Normal Individuals (2021). Journal of Alzheimer’s Disease. 79(4): 1801-1811. *co-first authors.

Yu, G.Z., Ly, M., Karim, H.T., Muppidi, N., Aizenstein, H.J., Ibinson, J.W. Accelerated brain aging in chronic low back pain (2021). Brain Research. 1755, 147263.

Ly, M., Karim, H.T., Becker, J.T., Lopez, O.L., Aizenstein, H.J., Reynolds, C.F. III., Zmuda, M.D., Butters, M.A. Late-life depression and increased risk of dementia: a longitudinal cohort study (2021). Translational Psychiatry. 11(1): 1-10.

Karim, H.T., Ly, M., Yu, G.Z., Krafty, R., Tudorsacu, D.L., Aizenstein, H.J., Andreescu, C. Aging faster: worry and rumination in late life are associated with greater brain age (2021). Neurobiology of Aging. 101 (13-21).

Trainee Name: J. Randall McAuley
Trainee: Past
Faculty Member: McAllister-Lucas, Linda
Publications:

McAuley JR, Freeman T, Ekambaram P, Lucas PC, and McAllister-Lucas LM (2018) CARMA3 is a critical mediator of G protein-coupled receptor and receptor tyrosine kinase-driven solid tumor pathogenesis. Front Immunol, 9:1887

McAuley JR, Bailey KM, Ekambaram P, Kang H, Hu D, Freeman TJ, Klei LR, Concel VJ, Hubel NE, Sekar P, Bridwell RE, Covic L, Lucas PC#, and McAllister-Lucas LM# (2018) MALT1 is a critical mediator of PAR1-driven NF-κB activation and metastasis in multiple tumor types. Oncogene, 38:7384-7398

Trainee Name: Randall McAuley
Trainee: Past
Faculty Member: Lucas, Peter
Publications:

McAuley JR, Freeman T, Ekambaram P, Lucas PC, and McAllister-Lucas LM (2018) CARMA3 is a critical mediator of G protein-coupled receptor and receptor tyrosine kinase-driven solid tumor pathogenesis. Front Immunol, 9:1887

McAuley JR, Bailey KM, Ekambaram P, Kang H, Hu D, Freeman TJ, Klei LR, Concel VJ, Hubel NE, Sekar P, Bridwell RE, Covic L, Lucas PC#, and McAllister-Lucas LM# (2018) MALT1 is a critical mediator of PAR1-driven NF-κB activation and metastasis in multiple tumor types. Oncogene, 38:7384-7398

Trainee Name: Pavle Milutinovic
Trainee: Past
Faculty Member: Oury, Tim
Publications:

Milutinovic PS, Englert JM, Crum LT, Mason NS, Ramsgaard L, Enghild JJ, Sparvero LJ, Lotze MT, Oury TD. Clearance kinetics and matrix binding partners of the receptor for advanced glycation end products. PLoS One. 2014 Mar 18;9(3):e88259. doi: 10.1371/journal.pone.0088259. PMID: 24642901; PMCID: PMC3958346.

Oczypok EA, Milutinovic PS, Alcorn JF, Khare A, Crum LT, Manni ML, Epperly MW, Pawluk AM, Ray A, Oury TD.

Pulmonary receptor for advanced glycation end-products promotes asthma pathogenesis through IL-33 and accumulation of group 2 innate lymphoid cells. J Allergy Clin Immunol. 2015 Sep;136(3):747-756.e4. doi: 10.1016/j.jaci.2015.03.011. Epub 2015 Apr 28. PMID: 25930197; PMCID: PMC4562894.

Milutinovic PS, Alcorn JF, Englert JM, Crum LT, Oury TD. The receptor for advanced glycation end products is a central mediator of asthma pathogenesis. Am J Pathol. 2012 Oct;181(4):1215-25. doi: 10.1016/j.ajpath.2012.06.031. Epub 2012 Aug 11. PMID: 22889845; PMCID: PMC3463633.

Englert JM, Kliment CR, Ramsgaard L, Milutinovic PS, Crum L, Tobolewski JM, Oury TD. Paradoxical function for the receptor for advanced glycation end products in mouse models of pulmonary fibrosis. Int J Clin Exp Pathol. 2011 Mar;4(3):241-54. Epub 2011 Mar 21. PMID: 21487520; PMCID: PMC3071657.

Ramsgaard L, Englert JM, Manni ML, Milutinovic PS, Gefter J, Tobolewski J, Crum L, Coudriet GM, Piganelli J, Zamora R, Vodovotz Y, Enghild JJ, Oury TD. Lack of the receptor for advanced glycation end-products attenuates E. coli pneumonia in mice. PLoS One. 2011;6(5):e20132. doi: 10.1371/journal.pone.0020132. Epub 2011 May 23. PMID: 21629785; PMCID: PMC3100338.

Perkins TN, Oczypok EA, Milutinovic PS, Dutz RE, Oury TD. RAGE-dependent VCAM-1 expression in the lung endothelium mediates IL-33-induced allergic airway inflammation. Allergy. 2019 Jan;74(1):89-99. doi: 10.1111/all.13500. Epub 2018 Nov 22. PMID: 29900561.

Milutinovic PS, Yang L, Cantor RS, Eger EI 2nd, Sonner JM. Anesthetic-like modulation of a gamma-aminobutyric acid type A, strychnine-sensitive glycine, and N-methyl-d-aspartate receptors by coreleased neurotransmitters. Anesth Analg. 2007 Aug;105(2):386-92. doi: 10.1213/01.ane.0000267258.17197.7d. PMID: 17646495.

Milutinovic PS, Zhao J, Sonner JM. Tolerance to isoflurane does not occur in developing Xenopus laevis tadpoles. Anesth Analg. 2009 Jan;108(1):176-80. doi: 10.1213/ane.0b013e31818ca33e. PMID: 19095846; PMCID: PMC2627504.

Trainee Name: Jared Moreines
Trainee: Past
Faculty Member: Grace, Anthony
Publications:

Moreines JL, Owrutsky ZL, Grace AA. Involvement of Infralimbic Prefrontal Cortex but not Lateral Habenula in Dopamine Attenuation After Chronic Mild Stress. Neuropsychopharmacology. 2017 Mar;42(4):904-913. doi: 10.1038/npp.2016.249. Epub 2016 Nov 4. PMID: 27813530; PMCID: PMC5312072.

Moreines JL, Owrutsky ZL, Gagnon KG, Grace AA. Divergent effects of acute and repeated quetiapine treatment on dopamine neuron activity in normal vs. chronic mild stress induced hypodopaminergic states. Transl Psychiatry. 2017 Dec 11;7(12):1275. doi: 10.1038/s41398-017-0039-9. PMID: 29225337; PMCID: PMC5802622.

Moreines JL, McClintock SM, Kelley ME, Holtzheimer PE, Mayberg HS. Neuropsychological function before and after subcallosal cingulate deep brain stimulation in patients with treatment-resistant depression. Depress Anxiety. 2014 Aug;31(8):690-8. doi: 10.1002/da.22263. Epub 2014 Apr 17. PMID: 24753183; PMCID: PMC4226070.

Trainee Name: Stephanie Myal
Trainee: Past
Faculty Member: Barth, Alison
Publications:

Urban-Ciecko J, Jouhanneau JS, Myal SE, Poulet JFA, Barth AL. Precisely Timed Nicotinic Activation Drives SST Inhibition in Neocortical Circuits. Neuron. 2018 Feb 7;97(3):611-625.e5. doi: 10.1016/j.neuron.2018.01.037. PMID: 29420933; PMCID: PMC6588401.

Trainee Name: Elizabeth A. Oczypok
Trainee: Past
Faculty Member: Oury, Tim D.
Publications:

Oczypok EA, Oury TD, Chu CT. It's a cell-eat-cell world: autophagy and phagocytosis. Am J Pathol. 2013 Mar;182(3):612-22. doi: 10.1016/j.ajpath.2012.12.017. Epub 2013 Jan 29. PMID: 23369575; PMCID: PMC3589073.

Gregory AD, Kliment CR, Metz HE, Kim KH, Kargl J, Agostini BA, Crum LT, Oczypok EA, Oury TA, Houghton AM. Neutrophil elastase promotes myofibroblast differentiation in lung fibrosis. J Leukoc Biol. 2015 Aug;98(2):143-52. doi: 10.1189/jlb.3HI1014-493R. Epub 2015 Mar 5. PMID: 25743626; PMCID: PMC4763951.

Oczypok EA, Milutinovic PS, Alcorn JF, Khare A, Crum LT, Manni ML, Epperly MW, Pawluk AM, Ray A, Oury TD. Pulmonary receptor for advanced glycation end-products promotes asthma pathogenesis through IL-33 and accumulation of group 2 innate lymphoid cells. J Allergy Clin Immunol. 2015 Sep;136(3):747-756.e4. doi: 10.1016/j.jaci.2015.03.011. Epub 2015 Apr 28. PMID: 25930197; PMCID: PMC4562894.

Oczypok EA, Oury TD. Electron microscopy remains the gold standard for the diagnosis of epithelial malignant mesothelioma: a case study. Ultrastruct Pathol. 2015 Apr;39(2):153-8. doi: 10.3109/01913123.2014.960542. Epub 2014 Sep 30. PMID: 25268063; PMCID: PMC4379130.

Oczypok EA, Perkins TN, Oury TD. Alveolar Epithelial Cell-derived Mediators: Potential Direct Regulators of Large Airway and Vascular Responses. Am J Respir Cell Mol Biol. 2017 Jan 12. doi: 10.1165/rcmb.2016-0151PS. [Epub ahead of print]

Oczypok EA, Perkins TN, Oury TD. All the "RAGE" in lung disease: The receptor for advanced glycation endproducts (RAGE) is a major mediator of pulmonary inflammatory responses. Paediatr Respir Rev. 2017 Jun;23:40-49. doi: 10.1016/j.prrv.2017.03.012. Epub 2017 Mar 18. PMID: 28416135; PMCID: PMC5509466.

Perkins TN, Oczypok EA, Milutinovic PS, Dutz RE, Oury TD. RAGE-dependent VCAM-1 expression in the lung endothelium mediates IL-33-induced allergic airway inflammation. Allergy. 2019 Jan;74(1):89-99. doi: 10.1111/all.13500. Epub 2018 Nov 22. PMID: 29900561.

Perkins TN, Oczypok EA, Dutz RE, Donnell ML, Myerburg MM, Oury TD. The receptor for advanced glycation end products is a critical mediator of type 2 cytokine signaling in the lungs. J Allergy Clin Immunol. 2019 Sep;144(3):796-808.e12. doi: 10.1016/j.jaci.2019.03.019. Epub 2019 Mar 30. PMID: 30940519.

Trainee Name: Tolani Olonisakin, MD, PhD
Trainee: Past
Faculty Member: Janet Lee, MD
Publications:

Bain W, Li H, van der Geest R, Moore SR, Olonisakin TF, Ahn B, Papke E, Moghbeli K, DeSensi R, Rapport S, Saul M, Hulver M, Xiong Z, Mallampalli RK, Ray P, Morris A, Ma L, Doi Y, Zhang Y, Kitsios GD, Kulkarni HS, McVerry BJ, Ferreira VP, Nouraie M, Lee JS. Increased Alternative Complement Pathway Function and Improved Survival during Critical Illness. Am J Respir Crit Care Med. 2020;202(2):230-40. Epub 2020/05/07. doi: 10.1164/rccm.201910-2083OC. PubMed PMID: 32374177; PMCID: PMC7365364.

Bain W, Olonisakin T, Yu M, Qu Y, Hulver M, Xiong Z, Li H, Pilewski J, Mallampalli RK, Nouraie M, Ray A, Ray P, Cheng Z, Shanks RMQ, St Croix C, Silverstein RL, Lee JS. Platelets inhibit apoptotic lung epithelial cell death and protect mice against infection-induced lung injury. Blood Adv. 2019;3(3):432-45. Epub 2019/02/09. doi: 10.1182/bloodadvances.2018026286. PubMed PMID: 30733303; PMCID: PMC6373758.

Han S, Olonisakin TF, Pribis JP, Zupetic J, Yoon JH, Holleran KM, Jeong K, Shaikh N, Rubio DM, Lee JS. A checklist is associated with increased quality of reporting preclinical biomedical research: A systematic review. PLoS One. 2017;12(9):e0183591. Epub 2017/09/14. doi: 10.1371/journal.pone.0183591. PubMed PMID: 28902887; PMCID: PMC5597130.

Olonisakin TF, Lee JS. Fighting Bacterial Pathogens in the Lung: Platelets to the Rescue? Am J Respir Cell Mol Biol. 2018;58(3):282-3. Epub 2018/03/02. doi: 10.1165/rcmb.2017-0349ED. PubMed PMID: 29493323; PMCID: PMC5854961.

Olonisakin TF, Li H, Xiong Z, Kochman EJ, Yu M, Qu Y, Hulver M, Kolls JK, St Croix C, Doi Y, Nguyen MH, Shanks RM, Mallampalli RK, Kagan VE, Ray A, Silverstein RL, Ray P, Lee JS. CD36 Provides Host Protection Against Klebsiella pneumoniae Intrapulmonary Infection by Enhancing Lipopolysaccharide Responsiveness and Macrophage Phagocytosis. J Infect Dis. 2016;214(12):1865-75. Epub 2016/09/30. doi: 10.1093/infdis/jiw451. PubMed PMID: 27683817; PMCID: PMC5142085.

Olonisakin TF, Suber T, Gonzalez-Ferrer S, Xiong Z, Penaloza HF, van der Geest R, Xiong Y, Osei-Hwedieh DO, Tejero J, Rosengart MR, Mars WM, Van Tyne D, Perlegas A, Brashears S, Kim-Shapiro DB, Gladwin MT, Bachman MA, Hod EA, St Croix C, Tyurina YY, Kagan VE, Mallampalli RK, Ray A, Ray P, Lee JS. Stressed erythrophagocytosis induces immunosuppression during sepsis through heme-mediated STAT1 dysregulation. J Clin Invest. 2021;131(1). Epub 2020/09/18. doi: 10.1172/JCI137468. PubMed PMID: 32941182; PMCID: PMC7773401.

Qu Y, Olonisakin T, Bain W, Zupetic J, Brown R, Hulver M, Xiong Z, Tejero J, Shanks RM, Bomberger JM, Cooper VS, Zegans ME, Ryu H, Han J, Pilewski J, Ray A, Cheng Z, Ray P, Lee JS. Thrombospondin-1 protects against pathogen-induced lung injury by limiting extracellular matrix proteolysis. JCI Insight. 2018;3(3). Epub 2018/02/09. doi: 10.1172/jci.insight.96914. PubMed PMID: 29415890; PMCID: PMC5821195.

Zhao Y, Olonisakin TF, Xiong Z, Hulver M, Sayeed S, Yu MT, Gregory AD, Kochman EJ, Chen BB, Mallampalli RK, Sun M, Silverstein RL, Stolz DB, Shapiro SD, Ray A, Ray P, Lee JS. Thrombospondin-1 restrains neutrophil granule serine protease function and regulates the innate immune response during Klebsiella pneumoniae infection. Mucosal Immunol. 2015;8(4):896-905. Epub 2014/12/11. doi: 10.1038/mi.2014.120. PubMed PMID: 25492474; PMCID: PMC4465063.

Trainee Name: Nolan Priedigkeit
Trainee: Past
Faculty Member: Lee, Adrian V
Publications:

Martignetti JA, Camacho-Vanegas O, Priedigkeit N, Camacho C, Pereira E, Lin L, Garnar- Wortzel L, Miller D, Losic B, Shah H, Liao J, Ma J, Lahiri P, Chee M, Schadt E, Dottino P. Personalized ovarian cancer disease surveillance and detection of candidate therapeutic drugtarget in circulating tumor DNA. Neoplasia. 2014 Jan;16(1):97-103. PMID: 24563622, PMCID: PMC3924545

Priedigkeit N, Wolfe N, Clark NL. 2015, Evolutionary signatures amongst disease genes permit novel methods for gene prioritization and construction of informative gene-based networks. PLoS Genet. 2015 Feb 13;11(2):e1004967. doi: 10.1371/journal.pgen.1004967. eCollection 2015 Feb. PMID: 25679399 PMCID: PMC4334549

Liu S, Tsai WH, Ding Y, Chen R, Fang Z, Huo Z, Kim S, Ma T, Chang TY, Priedigkeit NM, Lee AV, Luo J, Wang HW, Chung IF, Tseng GC. 2016, Comprehensive evaluation of fusion transcript detection algorithms and a meta-caller to combine top performing methods in paired-end RNA-seq data. Nucleic Acids Res. 2016 Mar 18;44(5):e47. doi: 10.1093/nar/gkv1234. Epub 2015 Nov 17. PMID: 26582927 PMCID: PMC4797269

Kim SH, Kaschula CH, Priedigkeit N, Lee AV, Singh SV. 2016, Forkhead Box Q1 Is a Novel Target of Breast Cancer Stem Cell Inhibition by Diallyl Trisulfide. J Biol Chem. 2016 Jun 24;291(26):13495-508. doi: 10.1074/jbc.M116.715219. Epub 2016 Apr 29. PMID: 27129776 PMCID: PMC4919436

Chen Y, Camacho SC, Silvers TR, Razak AR, Gabrail NY, Gerecitano JF, Kalir E, Pereira E, Evans BR, Ramus SJ, Huang F, Priedigkeit N, Rodriguez E, Donovan M, Khan F, Kalir T, Sebra R, Uzilov A, Chen R, Sinha R, Halpert R, Billaud JN, Shacham S, McCauley D, Landesman Y, Rashal T, Kauffman M, Mirza MR, Mau-Sørensen M, Dottino P, Martignetti JA. 2017, Inhibition of the Nuclear Export Receptor XPO1 as a Therapeutic Target for Platinum- Resistant Ovarian Cancer. Clin Cancer Res. 2017 Mar 15;23(6):1552-1563. doi: 10.1158/1078-0432.CCR-16-1333. Epub 2016 Sep 20. PMID: 27649553

Priedigkeit N, Hartmaier RJ, Chen Y, Vareslija D, Basudan A, Watters RJ, Thomas R, Leone JP, Lucas PC, Bhargava R, Hamilton RL, Chmielecki J, Puhalla SL, Davidson NE, Oesterreich S, Brufsky AM, Young L, Lee AV. 2017, Intrinsic Subtype Switching and Acquired ERBB2/HER2 Amplifications and Mutations in Breast Cancer Brain Metastases. JAMA Oncol. 2017 May 1;3(5):666-671. doi: 10.1001/jamaoncol.2016.5630. PMID: 27926948 PMCID: PMC5508875

Priedigkeit N, Watters RJ, Lucas PC, Basudan A, Bhargava R, Horne W, Kolls JK, Fang Z, Rosenzweig MQ, Brufsky AM, Weiss KR, Oesterreich S, Lee AV. 2017 Exome-capture RNA sequencing of decade-old breast cancers and matched decalcified bone metastases. JCI Insight. 2017 Sep 7;2(17). pii: 95703. doi: 10.1172/jci.insight.95703. [Epub ahead of print] PMID: 28878133 PMCID: PMC5621874

Ekambaram P, Lee JL, Hubel NE, Hu D, Yerneni S, Campbell PG, Pollock N, Klei LR, Concel VJ, Delekta PC, Chinnaiyan AM, Tomlins SA, Rhodes DR, Priedigkeit N, Lee AV, Oesterreich S, McAllister-Lucas LM, Lucas PC. 2018, The CARMA3-Bcl10-MALT1 Signalosome Drives NFκB Activation and Promotes Aggressiveness in Angiotensin II Receptor-Positive Breast Cancer. Cancer Res. 2018 Mar 1;78(5):1225-1240. doi: 10.1158/0008-5472.CAN-17-1089. Epub 2017 Dec 19. PMID: 29259013

Hartmaier RJ, Trabucco SE, Priedigkeit N, Chung JH, Parachoniak CA, Vanden Borre P, Morley S, Rosenzweig M, Gay LM, Goldberg ME, Suh J, Ali SM, Ross J, Leyland-Jones B, Young B, Williams C, Park B, Tsai M, Haley B, Peguero J, Callahan RD, Sachelarie I, Cho J, Atkinson JM, Bahreini A, Nagle AM, Puhalla SL, Watters RJ, Erdogan-Yildirim Z, Cao L, Oesterreich S, Mathew A, Lucas PC, Davidson NE, Brufsky AM, Frampton GM, Stephens PJ, Chmielecki J, Lee AV. 2018, Recurrent hyperactive ESR1 fusion proteins in endocrine therapy-resistant breast cancer. Ann Oncol. 2018 Apr 1;29(4):872-880. doi: 10.1093/annonc/mdy025. PMID: 29360925 PMCID: PMC5913625

Basudan A, Priedigkeit N, Hartmaier RJ, Sokol ES, Bahreini A, Watters RJ, Boisen MM, Bhargava R, Weiss KR, Karsten MM, Denkert C, Blohmer JU, Leone JP, Hamilton RL, Brufsky AM, Elishaev E, Lucas PC, Lee AV, Oesterreich S. Frequent ESR1 and CDK Pathway Copy Number Alterations in Metastatic Breast Cancer. Mol Cancer Res. 2018 Oct 24. pii: molcanres.0946.2018. doi: 10.1158/1541-7786.MCR-18-0946. PMID: 30355675 PMCID: PMC6359977

Trainee Name: Josiah Radder
Trainee: Past
Faculty Member: Shapiro, Steven
Publications:

Radder JE, Gregory AD, Leme AS, Cho MH, Chu Y, Kelly NJ, Bakke P, Gulsvik A, Litonjua AA, Sparrow D, Beaty TH, Crapo JD, Silverman EK, Zhang Y, Berndt A, Shapiro SD. 2017. Variable Susceptibility to Cigarette Smoke-Induced Emphysema in 34 Inbred Strains of Mice Implicates Abi3bp in Emphysema Susceptibility. Am J Respir Cell Mol Biol. 367-375. PMID: 28441029.

Dandachi N, Kelly NJ, Wood JP, Burton CL, Radder JE, Leme AS, Gregory AD, Shapiro SD. Macrophage Elastase Induces TRAIL-mediated Tumor Cell Death through Its Carboxy-Terminal Domain.2017. Am J Respir Crit Care Med. 353-363. PMID: 28345958.

Radder JE, Zhang Y, Gregory AD, Yu S, Kelly NJ, Leader JK, Kaminski N, Sciurba FC, Shapiro SD. 2017. Extreme Trait Whole-Genome Sequencing Identifies PTPRO as a Novel Candidate Gene in Emphysema with Severe Airflow Obstruction. Am J Respir Crit Care Med. 159-171. PMID: 28199135

Meng Q, Lai YC, Kelly NJ, Bueno M, Baust JJ, Bachman TN, Goncharov D, Vanderpool RR, Radder JE, Hu J, Goncharova E, Morris AM, Mora AL, Shapiro SD, Gladwin MT. 2017. Development of a Mouse Model of Metabolic Syndrome, Pulmonary Hypertension, and Heart Failure with Preserved Ejection Fraction. Am J Respir Cell Mol Biol. 497-505. PMID: 58118022.

Kelly NJ, Radder JE, Baust JJ, Burton CL, Lai YC, Potoka KC, Agostini BA, Wood JP, Bachman TN, Vanderpool RR, Dandachi N, Leme AS, Gregory AD, Morris A, Mora AL, Gladwin MT, Shapiro SD. 2017. Mouse Genome-Wide Association Study of Preclinical Group II Pulmonary Hypertension Identifies Epidermal Growth Factor Receptor. Am J Respir Cell Mol Biol. 488-496. PMID: 28085498.

Kelly NJ, Dandachi N, Goncharov DA, Pena AZ, Radder JE, Gregory AD, Lai YC, Leme AS, Gladwin MT, Goncharova EA, St Croix CM, Shapiro SD. 2016. Automated Measurement of Blood Vessels in Tissues from Microscopy Images. Curr Protoc Cytom. 12.44.1-12.44.13. PMID: 27723088

Weathington NM, Álvarez D, Sembrat J, Radder J, Cárdenes N, Noda K, Gong Q, Wong H, Kolls J, D'Cunha J, Mallampalli RK, Chen BB, Rojas M. Ex vivo lung perfusion as a human platform for preclinical small molecule testing. JCI Insight. 2018 Oct 4;3(19):e95515

Radder JE, Shapiro SD. Reply to: Quantitative Histology Seriously Flawed by Lack of Lung Volume Measurement. Am J Respir Cell Mol Biol. 2018 Feb;58(2):274-275.

Radder JE, Shapiro SD, Berndt A. Personalized medicine for chronic, complex diseases: chronic obstructive pulmonary disease as an example. Per Med. 2014 Sep;11(7):669-679.

Norris CA, He M, Kang LI, Ding MQ, Radder JE, Haynes MM, Yang Y, Paranjpe S, Bowen WC, Orr A, Michalopoulos GK, Stolz DB, Mars WM. Synthesis of IL-6 by hepatocytes is a normal response to common hepatic stimuli. PLoS One. 2014 Apr 24;9(4):e96053.

Trainee Name: Robert Rasmussen
Trainee: Past
Faculty Member: Schwartz, Andrew
Publications:

Rasmussen RG, Schwartz A, Chase SM. Dynamic range adaptation in primary motor cortical populations. Elife. 2017 Apr 18;6:e21409. doi: 10.7554/eLife.21409. PMID: 28417848; PMCID: PMC5395298.

Trainee Name: Daniel Roh
Trainee: Past
Faculty Member: Funderburgh, James
Publications:

Roh DS, Du Y, Gabriele ML, Robinson AR, Niedernhofer LJ, Funderburgh JL. Age-related dystrophic changes in corneal endothelium from DNA repair-deficient mice. Aging Cell. 2013 Dec;12(6):1122-31. doi: 10.1111/acel.12143. Epub 2013 Sep 1. PMID: 23927039; PMCID: PMC4116745.

Roh DS, Cook AL, Rhee SS, Joshi A, Kowalski R, Dhaliwal DK, Funderburgh JL. DNA cross-linking, double-strand breaks, and apoptosis in corneal endothelial cells after a single exposure to mitomycin C. Invest Ophthalmol Vis Sci. 2008 Nov;49(11):4837-43. doi: 10.1167/iovs.08-2115. Epub 2008 Jul 24. PMID: 18658091; PMCID: PMC2875544.

Roh DS, Funderburgh JL. Impact on the corneal endothelium of mitomycin C during photorefractive keratectomy. J Refract Surg. 2009 Oct;25(10):894-7. doi: 10.3928/1081597X-20090617-10. Epub 2009 Oct 12. PMID: 19835330; PMCID: PMC2876307.

Du Y, Roh DS, Funderburgh ML, Mann MM, Marra KG, Rubin JP, Li X, Funderburgh JL. Adipose-derived stem cells differentiate to keratocytes in vitro. Mol Vis. 2010 Dec 10;16:2680-9. PMID: 21179234; PMCID: PMC3002955.

Roh DS, Funderburgh JL. Rapid changes in connexin-43 in response to genotoxic stress stabilize cell-cell communication in corneal endothelium. Invest Ophthalmol Vis Sci. 2011 Jul 15;52(8):5174-82. doi: 10.1167/iovs.11-7272. PMID: 21666237; PMCID: PMC3176070.

Du Y, Roh DS, Mann MM, Funderburgh ML, Funderburgh JL, Schuman JS. Multipotent stem cells from trabecular meshwork become phagocytic TM cells. Invest Ophthalmol Vis Sci. 2012 Mar 21;53(3):1566-75. doi: 10.1167/iovs.11-9134. PMID: 22297497; PMCID: PMC3339918.

Fujita M, Mehra R, Lee SE, Roh DS, Long C, Funderburgh JL, Ayares DL, Cooper DK, Hara H. Comparison of proliferative capacity of genetically-engineered pig and human corneal endothelial cells. Ophthalmic Res. 2013;49(3):127-38. doi: 10.1159/000342978. Epub 2012 Dec 18. PMID: 23258190; PMCID: PMC3763511.

Lee SE, Mehra R, Fujita M, Roh DS, Long C, Lee W, Funderburgh JL, Ayares DL, Cooper DK, Hara H. Characterization of porcine corneal endothelium for xenotransplantation. Semin Ophthalmol. 2014 May;29(3):127-35. doi: 10.3109/08820538.2013.787104. Epub 2013 Jun 12. PMID: 23758340.

Hara H, Koike N, Long C, Piluek J, Roh DS, SundarRaj N, Funderburgh JL, Mizuguchi Y, Isse K, Phelps CJ, Ball SF, Ayares DL, Cooper DK. Initial in vitro investigation of the human immune response to corneal cells from genetically engineered pigs. Invest Ophthalmol Vis Sci. 2011 Jul 15;52(8):5278-86. doi: 10.1167/iovs.10-6947. PMID: 21596821; PMCID: PMC3176056.

Boote C, Du Y, Morgan S, Harris J, Kamma-Lorger CS, Hayes S, Lathrop KL, Roh DS, Burrow MK, Hiller J, Terrill NJ, Funderburgh JL, Meek KM. Quantitative assessment of ultrastructure and light scatter in mouse corneal debridement wounds. Invest Ophthalmol Vis Sci. 2012 May 14;53(6):2786-95. doi: 10.1167/iovs.11-9305. PMID: 22467580; PMCID: PMC3367468.

Trainee Name: Brian Rosborough
Trainee: Past
Faculty Member: Thomson, Angus
Publications:

Chen, L. C., Y. T. Nicholson, B. R. Rosborough, A. W. Thomson, and G. Raimondi. 2016. A Novel mTORC1-Dependent, Akt-Independent Pathway Differentiates the Gut Tropism of Regulatory and Conventional CD4 T Cells. Journal of immunology 197:1137-1147.

Corbitt, N., S. Kimura, K. Isse, S. Specht, L. Chedwick, B. R. Rosborough, J. G. Lunz, N. Murase, S. Yokota, and A. J. Demetris. 2013. Gut bacteria drive Kupffer cell expansion via MAMP-mediated ICAM-1 induction on sinusoidal endothelium and influence preservation-reperfusion injury after orthotopic liver transplantation. The American journal of pathology 182:180-191.

Huang, H., H. W. Chen, J. Evankovich, W. Yan, B. R. Rosborough, G. W. Nace, Q. Ding, P. Loughran, D. Beer-Stolz, T. R. Billiar, C. T. Esmon, and A. Tsung. 2013. Histones activate the NLRP3 inflammasome in Kupffer cells during sterile inflammatory liver injury. Journal of immunology 191:2665-2679.

Huang, H., G. W. Nace, K. A. McDonald, S. Tai, J. R. Klune, B. R. Rosborough, Q. Ding, P. Loughran, X. Zhu, D. Beer-Stolz, E. B. Chang, T. Billiar, and A. Tsung. 2014. Hepatocyte-specific high-mobility group box 1 deletion worsens the injury in liver ischemia/reperfusion: a role for intracellular high-mobility group box 1 in cellular protection. Hepatology 59:1984-1997.

Matta, B. M., J. M. Lott, L. R. Mathews, Q. Liu, B. R. Rosborough, B. R. Blazar, and H. R. Turnquist. 2014. IL-33 is an unconventional Alarmin that stimulates IL-2 secretion by dendritic cells to selectively expand IL-33R/ST2+ regulatory T cells. Journal of immunology 193:4010-4020.

Matta, B. M., G. Raimondi, B. R. Rosborough, T. L. Sumpter, and A. W. Thomson. 2012. IL-27 production and STAT3-dependent upregulation of B7-H1 mediate immune regulatory functions of liver plasmacytoid dendritic cells. Journal of immunology 188:5227-5237.

Nace, G. W., H. Huang, J. R. Klune, R. E. Eid, B. R. Rosborough, S. Korff, S. Li, R. A. Shapiro, D. B. Stolz, C. P. Sodhi, D. J. Hackam, D. A. Geller, T. R. Billiar, and A. Tsung. 2013. Cellular-specific role of toll-like receptor 4 in hepatic ischemia-reperfusion injury in mice. Hepatology 58:374-387.

Raich-Regue, D., B. R. Rosborough, A. R. Watson, M. J. McGeachy, H. R. Turnquist, and A. W. Thomson. 2015. mTORC2 Deficiency in Myeloid Dendritic Cells Enhances Their Allogeneic Th1 and Th17 Stimulatory Ability after TLR4 Ligation In Vitro and In Vivo. Journal of immunology 194:4767-4776.

Rosborough, B. R., A. Castellaneta, S. Natarajan, A. W. Thomson, and H. R. Turnquist. 2012. Histone deacetylase inhibition facilitates GM-CSF-mediated expansion of myeloid-derived suppressor cells in vitro and in vivo. Journal of leukocyte biology 91:701-709.

Rosborough, B. R., H. Hackstein, and H. R. Turnquist. 2014. A window into immunosuppressant immunoregulation: recipient conversion to rapamycin increases potentially tolerogenic immune cells. Kidney international 85:743-745.

Rosborough, B. R., L. R. Mathews, B. M. Matta, Q. Liu, D. Raich-Regue, A. W. Thomson, and H. R. Turnquist. 2014. Cutting edge: Flt3 ligand mediates STAT3-independent expansion but STAT3-dependent activation of myeloid-derived suppressor cells. Journal of immunology 192:3470-3473.

Rosborough, B. R., D. Raich-Regue, Q. Liu, R. Venkataramanan, H. R. Turnquist, and A. W. Thomson. 2014. Adenosine triphosphate-competitive mTOR inhibitors: a new class of immunosuppressive agents that inhibit allograft rejection. American journal of transplantation 14:2173-2180.

Rosborough, B. R., D. Raich-Regue, B. M. Matta, K. Lee, B. Gan, R. A. DePinho, H. Hackstein, M. Boothby, H. R. Turnquist, and A. W. Thomson. 2013. Murine dendritic cell rapamycin-resistant and rictor-independent mTOR controls IL-10, B7-H1, and regulatory T-cell induction. Blood 121:3619-3630.

Rosborough, B. R., D. Raich-Regue, H. R. Turnquist, and A. W. Thomson. 2014. Regulatory myeloid cells in transplantation. Transplantation 97:367-379.

Stenger, E. O., B. R. Rosborough, L. R. Mathews, H. Ma, M. Y. Mapara, A. W. Thomson, and H. R. Turnquist. 2014. IL-12hi rapamycin-conditioned dendritic cells mediate IFN-gamma-dependent apoptosis of alloreactive CD4+ T cells in vitro and reduce lethal graft-versus-host disease. Biology of blood and marrow transplantation 20:192-201.

Turnquist, H. R., J. Cardinal, C. Macedo, B. R. Rosborough, T. L. Sumpter, D. A. Geller, D. Metes, and A. W. Thomson. 2010. mTOR and GSK-3 shape the CD4+ T-cell stimulatory and differentiation capacity of myeloid DCs after exposure to LPS. Blood 115:4758-4769.

Turnquist, H. R., Z. Zhao, B. R. Rosborough, Q. Liu, A. Castellaneta, K. Isse, Z. Wang, M. Lang, D. B. Stolz, X. X. Zheng, A. J. Demetris, F. Y. Liew, K. J. Wood, and A. W. Thomson. 2011. IL-33 expands suppressive CD11b+ Gr-1(int) and regulatory T cells, including ST2L+ Foxp3+ cells, and mediates regulatory T cell-dependent promotion of cardiac allograft survival. Journal of immunology 187:4598-4610.

Zhang, L., J. S. Cardinal, P. Pan, B. R. Rosborough, Y. Chang, W. Yan, H. Huang, T. R. Billiar, M. R. Rosengart, and A. Tsung. 2012. Splenocyte apoptosis and autophagy is mediated by interferon regulatory factor 1 during murine endotoxemia. Shock 37:511-517.

Trainee Name: Emily Rosenberger
Trainee: Past
Faculty Member: Dew, Mary Amanda
Publications:

Rogal S, Shenai N, Kruckenberg K, Rosenberger E, Dew MA, DiMartini A. Post transplant Outcomes of Persons Receiving a Liver Graft for Alcoholic Liver Disease. Alcohol Alcohol. 2018 Mar 1;53(2):157-165.

Rosenberger EM, DeVito Dabbs AJ, DiMartini AF, Landsittel DP, Pilewski JM, Dew MA. Long-Term Follow-up of a Randomized Controlled Trial Evaluating a Mobile Health Intervention for Self-Management in Lung Transplant Recipients. Am J Transplant. 2017 May;17(5):1286-1293.

Dew MA, Rosenberger EM, Myaskovsky L, DiMartini AF, DeVito Dabbs AJ, Posluszny DM, Steel J, Switzer GE, Shellmer DA, Greenhouse JB. Depression and Anxiety as Risk Factors for Morbidity and Mortality After Organ Transplantation: A Systematic Review and Meta-Analysis. Transplantation. 2015 May;100(5):988-1003.

Faeder S, Moschenross D, Rosenberger E, Dew MA, DiMartini A. Psychiatric aspects of organ transplantation and donation. Curr Opin Psychiatry. 2015 Sep;28(5):357-64.

Rosenberger EM, DiMartini AF, DeVito Dabbs AJ, Bermudez CA, Pilewski JM, Toyoda Y, Dew MA. Psychiatric Predictors of Long-term Transplant Related Outcomes in Lung Transplant Recipients. Transplantation. 2016 Jan; 100(1):239-47.

Rosenberger EM, Dew MA, DiMartini AF, DeVito Dabbs AJ, Yusen RD. Psychosocial issues facing lung transplant candidates, recipients and family caregivers. Thorac Surg Clin. 2012 Nov;22(4):517-29.

Rosenberger EM, Fox KR, DiMartini AF, Dew MA. Psychosocial factors and quality-of-life after heart transplantation and mechanical circulatory support. Curr Opin Organ Transplant. 2012 Oct;17(5):558-63.

Rosenberger EM, Dew MA, Crone C, DiMartini AF. Psychiatric disorders as risk factors for adverse medical outcomes after solid organ transplantation. Curr Opin Organ Transplant. 2012 Apr;17(2):188-92.

Broyles LM, Rosenberger E, Hanusa BH, Kraemer KL, Gordon AJ. Hospitalized patients' acceptability of nurse-delivered screening, brief intervention, and referral to treatment. Alcohol Clin Exp Res. 2012 Apr;36(4):725-31.

Trainee Name: Benjamin Rothrauff
Trainee: Past
Faculty Member: Tuan, Rocky
Publications:

Rothrauff BB, Yang G, Tuan RS. 2017. Tissue-specific bioactivity of soluble tendon-derived and cartilage-derived extracellular matrices on adult mesenchymal stem cells. Stem Cell Res Ther. PMID: 28583182.

Rothrauff BB, Coluccino L, Gottardi R, Ceseracciu L, Scaglione S, Goldoni L, Tuan RS. 2017.  Efficacy of thermoresponsive, photocrosslinkable hydrogels derived from decellularized tendon and cartilage extracellular matrix for cartilage tissue engineering. J Tissue Eng Regen Med. PMID: 28486778.

Stearns-Reider KM, D'Amore A, Beezhold K, Rothrauff B, Cavalli L, Wagner WR, Vorp DA, Tsamis A, Shinde S, Zhang C, Barchowsky A, Rando TA, Tuan RS, Ambrosio F. 2017. Aging of the skeletal muscle extracellular matrix drives a stem cell fibrogenic conversion. Aging Cell. PMID: 28371268.

Rothrauff BB, Pauyo T, Debski RE, Rodosky MW, Tuan RS, Musahl V. 2017. The Rotator Cuff Organ: Integrating Developmental Biology, Tissue Engineering, and Surgical Considerations to Treat Chronic Massive Rotator Cuff Tears. Tissue Eng Part B Rev. PMID: 28084902.

Rothrauff BB, Lauro BB, Yang G, Debski RE, Musahl V, Tuan RS. 2017. Braided and Stacked Electrospun Nanofibrous Scaffolds for Tendon and Ligament Tissue Engineering. Tissue Eng Part A. PMID: 28071988.

Shimomura K, Rothrauff BB, Tuan RS. 2017. Region-Specific Effect of the Decellularized Meniscus Extracellular Matrix on Mesenchymal Stem Cell-Based Meniscus Tissue Engineering. Am J Sports Med. PMID: 27895039

Rothrauff BB, Shimomura K, Gottardi R, Alexander PG, Tuan RS. 2017 Anatomical region-dependent enhancement of 3-dimensional chondrogenic differentiation of human mesenchymal stem cells by soluble meniscus extracellular matrix. Acta Biomater. PMID: 27876676

Yang G, Rothrauff BB, Lin H, Yu S, Tuan RS. 2017. Tendon-Derived Extracellular Matrix Enhances Transforming Growth Factor-β3-Induced Tenogenic Differentiation of Human Adipose-Derived Stem Cells. Tissue Eng Part A. PMID:27809678

Numpaisal PO, Rothrauff BB, Gottardi R, Chien CL, Tuan RS. 2017. Rapidly dissociated autologous meniscus tissue enhances meniscus healing: An in vitro study. Connect Tissue Res. PMID: 27726454.

Dombrowski ME, Costello JM, Ohashi B, Murawski CD, Rothrauff BB, Arilla FV, Friel NA, Fu FH, Debski RE, Musahl V. 2016. Macroscopic anatomical, histological and magnetic resonance imaging correlation of the lateral capsule of the knee. Knee Surg Sports Traumatol Arthrosc. PMID: 25649729.

Hoshino Y, Rothrauff BB, Hensler D, Fu Fh, MusahI V. 2016. Arthroscopic image distortion-part II: the effect of lens angle and portal location in a 3D knee model. Knew Surg Sports Traumatol Arthrosc. PMID: 25248308

van Dijk PAD, Murawski CD, Hunt KJ, Andrews CL, Longo UG, McCollum G, Simpson H, Sofka CM, Yoshimura I, Karlsson J; International Consensus Group on Cartilage Repair of the Ankle. Post-treatment Follow-up, Imaging, and Outcome Scores: Proceedings of the International Consensus Meeting on Cartilage Repair of the Ankle. Foot Ankle Int. 2018 Jul;39(1_suppl):68S-73S.

Mittwede PN, Murawski CD, Ackermann J, Görtz S, Hintermann B, Kim HJ, Thordarson DB, Vannini F, Younger ASE; International Consensus Group on Cartilage Repair of the Ankle. Revision and Salvage Management: Proceedings of the International Consensus Meeting on Cartilage Repair of the Ankle. Foot Ankle Int. 2018 Jul;39(1_suppl):54S-60S. doi: 10.1177/1071100718781863.

Dombrowski ME, Yasui Y, Murawski CD, Fortier LA, Giza E, Haleem AM, Hamid K, Tuan R, Zhang Z, Schon LC, Hogan MV; International Consensus Group on Cartilage Repair of the Ankle. Conservative Management and Biological Treatment Strategies: Proceedings of the International Consensus Meeting on Cartilage Repair of the Ankle. Foot Ankle Int. 2018 Jul;39(1_suppl):9S-15S.

D'Hooghe P, Murawski CD, Boakye LAT, Osei-Hwedieh DO, Drakos MC, Hertel J, Lee KB, Popchak A, Wiewiorski M, van Dijk CN; International Consensus Group on Cartilage Repair of the Ankle. Rehabilitation and Return to Sports: Proceedings of the International Consensus Meeting on Cartilage Repair of the Ankle. Foot Ankle Int. 2018 Jul;39(1_suppl):61S-67S.

Rothrauff BB, Murawski CD, Angthong C, Becher C, Nehrer S, Niemeyer P, Sullivan M, Valderrabano V, Walther M, Ferkel RD; International Consensus Group on Cartilage Repair of the Ankle. Scaffold-Based Therapies: Proceedings of the International Consensus Meeting on Cartilage Repair of the Ankle. Foot Ankle Int. 2018 Jul;39(1_suppl):41S-47S. doi: 10.1177/1071100718781864.

Shimozono Y, Brown AJ, Batista JP, Murawski CD, Gomaa M, Kong SW, Vaseenon T, Takao M, Glazebrook M; International Consensus Group on Cartilage Repair of the Ankle Subchondral Pathology: Proceedings of the International Consensus Meeting on Cartilage Repair of the Ankle. Foot Ankle Int. 2018 Jul; 39(1_suppl):48S-53S.

Reilingh ML, Murawski CD, DiGiovanni CW, Dahmen J, Ferrao PNF, Lambers KTA, Ling JS, Tanaka Y, Kerkhoffs GMMJ; International Consensus Group on Cartilage Repair of the Ankle. Fixation Techniques: Proceedings of the International Consensus Meeting on Cartilage Repair of the Ankle. Foot Ankle Int. 2018 Jul;39(1_suppl):23S-27S.

Hurley ET, Murawski CD, Paul J, Marangon A, Prado MP, Xu X, Hangody L, Kennedy JG; International Consensus Group on Cartilage Repair of the Ankle. Osteochondral Autograft: Proceedings of the International Consensus Meeting on Cartilage Repair of the Ankle. Foot Ankle Int. 2018 Jul;39(1_suppl): 28S-34S.

Smyth NA, Murawski CD, Adams SB Jr, Berlet GC, Buda R, Labib SA, Nunley JA 2nd, Raikin SM; International Consensus Group on Cartilage Repair of the Ankle. Osteochondral Allograft: Proceedings of the International Consensus Meeting on Cartilage Repair of the Ankle. Foot Ankle Int. 2018 Jul;39(1_suppl): 35S-40S.

Hannon CP, Bayer S, Murawski CD, Canata GL, Clanton TO, Haverkamp D, Lee JW, O'Malley MJ, Yinghui H, Stone JW; International Consensus Group on Cartilage Repair of the Ankle. Debridement, Curettage, and Bone Marrow Stimulation: Proceedings of the International Consensus Meeting on Cartilage Repair of the Ankle. Foot Ankle Int. 2018 Jul;39(1_suppl):16S-22S.

van Bergen CJA, Baur OL, Murawski CD, Spennacchio P, Carreira DS, Kearns SR, Mitchell AW, Pereira H, Pearce CJ, Calder JDF; International Consensus Group on Cartilage Repair of the Ankle. Diagnosis: History, Physical Examination, Imaging, and Arthroscopy: Proceedings of the International Consensus Meeting on Cartilage Repair of the Ankle. Foot Ankle Int. 2018 Jul;39(1_suppl): 3S-8S.

Liou JJ, Rothrauff BB, Alexander PG, Tuan RS. Effect of Platelet Rich Plasma on Chondrogenic Differentiation of Adipose- and Bone Marrow-Derived Mesenchymal Stem Cells. Tissue Eng Part A. 2018 Oct;24(19-20):1432-1443.

Sasaki H, Rothrauff BB, Alexander PG, Lin H, Gottardi R, Fu FH, Tuan RS. In Vitro Repair of Meniscal Radial Tear With Hydrogels Seeded With Adipose Stem Cells and TGF-β3. Am J Sports Med. 2018 Aug;46(10):2402-2413.

Rothrauff BB, Numpaisal PO, Lauro BB, Alexander PG, Debski RE, Musahl V, Tuan RS. Augmented repair of radial meniscus tear with biomimetic electrospun scaffold: an in vitro mechanical analysis. J Exp Orthop. 2016 Dec; 3(1):23.

Arilla FV, Yeung M, Bell K, Rahnemai-Azar AA, Rothrauff BB, Fu FH, Debski RE, Ayeni OR, Musahl V. Authors' Reply. Arthroscopy. 2016 May;32(5): 730-1.

Arilla FV, Yeung M, Bell K, Rahnemai-Azar AA, Rothrauff BB, Fu FH, Debski RE, Ayeni OR, Musahl V. Authors' Reply. Arthroscopy. 2016 May;32(5): 730-1.

Arilla FV, Yeung M, Bell K, Rahnemai-Azar AA, Rothrauff BB, Fu FH, Debski RE, Ayeni OR, Musahl V. Experimental Execution of the Simulated Pivot Shift Test: A Systematic Review of Techniques. Arthroscopy. 2015 Dec;31(12):2445-54.e2.

Kowalczuk M, Leblanc MC, Rothrauff BB, Debski RE, Musahl V, Simunovic N, Ayeni OR. Posterior tibial translation resulting from the posterior drawer manoeuver in cadaveric knee specimens: a systematic review. Knee Surg Sports Traumatol Arthrosc. 2015 Oct;23(10):2974-82.

Van der Watt L, Khan M, Rothrauff BB, Ayeni OR, Musahl V, Getgood A, Peterson D. The structure and function of the anterolateral ligament of the knee: a systematic review. Arthroscopy. 2015 Mar;31(3):569-82.e3. doi: 10.1016/j.arthro.2014.12.015. PMID: 25744324.

Hoshino Y, Rothrauff BB, Hensler D, Fu FH, Musahl V. Arthroscopic image distortion-part I: the effect of lens and viewing angles in a 2- dimensional in vitro model. Knee Surg Sports Traumatol Arthrosc. 2016 Jun;24(6): 2065-71.

Khan M, Rothrauff BB, Merali F, Musahl V, Peterson D, Ayeni OR. Management of the contaminated anterior cruciate ligament graft. Arthroscopy. 2014 Feb;30(2):236-44.

Rothrauff BB, Tuan RS. Cellular therapy in bone-tendon interface regeneration. Organogenesis. 2014 Jan 1;10(1):13-28.

Yang G, Rothrauff BB, Tuan RS. Tendon and ligament regeneration and repair: clinical relevance and developmental paradigm. Birth Defects Res C Embryo Today. 2013 Sep;99(3):203-222.

Yang G, Rothrauff BB, Lin H, Gottardi R, Alexander PG, Tuan RS. Enhancement of tenogenic differentiation of human adipose stem cells by tendon derived extracellular matrix. Biomaterials. 2013 Dec;34(37):9295-306.

Rothrauff BB, Smith CA, Ferrer GA, Novaretti JV, Pauyo T, Chao T, Hirsch D, Beaudry MF, Herbst E, Tuan RS, Debski RE, Musahl V. The effect of adipose derived stem cells on enthesis healing after repair of acute and chronic massive rotator cuff tears in rats. J Shoulder Elbow Surg. 2019 Apr;28(4): 654-664.

Trainee Name: Melanie Ruffner
Trainee: Past
Faculty Member: Robbins, Paul
Publications:

Yang C, Ruffner MA, Kim SH, Robbins PD. Plasma-derived MHC class II+ exosomes from tumor-bearing mice suppress tumor antigen-specific immune responses. Eur J Immunol. 2012 Jul;42(7):1778-84. doi: 10.1002/eji.201141978. PMID: 22585706; PMCID: PMC3471134.

Ruffner MA, Robbins PD. Dendritic cells transduced to express interleukin 4 reduce diabetes onset in both normoglycemic and prediabetic nonobese diabetic mice. PLoS One. 2010 Jul 29;5(7):e11848. doi: 10.1371/journal.pone.0011848. PMID: 20686610; PMCID: PMC2912295.

Bianco NR, Kim SH, Ruffner MA, Robbins PD. Therapeutic effect of exosomes from indoleamine 2,3-dioxygenase-positive dendritic cells in collagen-induced arthritis and delayed-type hypersensitivity disease models. Arthritis Rheum. 2009 Feb;60(2):380-9. doi: 10.1002/art.24229. PMID: 19180475; PMCID: PMC3491653.

Ruffner MA, Kim SH, Bianco NR, Francisco LM, Sharpe AH, Robbins PD. B7-1/2, but not PD-L1/2 molecules, are required on IL-10-treated tolerogenic DC and DC-derived exosomes for in vivo function. Eur J Immunol. 2009 Nov;39(11):3084-90. doi: 10.1002/eji.200939407. PMID: 19757438; PMCID: PMC3075967.

Trainee Name: Ranmal Samarasinghe
Trainee: Past
Faculty Member: DeFranco, Donald B.
Publications:

Ho Y*, Samarasinghe R*, Knoch ME, Lewis M, Aizenman E, DeFranco DB. 2008, Selective inhibition of MAPK phosphatases by zinc accounts for ERK1/2-dependent oxidative neuronal cell death. Molecular Pharmacology 74, 1141-1151. (*co-first authors) PMID: 18635668 PMCID: PMC2575064

Samarasinghe RA, Di Maio R, Volonte D, Galbiati, F, Lewis M, Romero G, DeFranco DB 2011, Non-genomic glucocorticoid receptor action regulates gap junction intercellular communication and neural progenitor cell proliferation. Proc. Natl. Acad. Sci. USA 108, 16657- 16662. PMID: 21930911 PMCID: PMC3189065

Samarasinghe RA, Kanuparthi PS, Greenamyre JT, *DeFranco DB & Di Maio R 2014, Transient muscarinic and glutamatergic stimulation of neural stem cells trigger acute and persistent changes in differentiation. Neurobiol. Disease 70, 252-261. *Corresponding and co- senior author. PMID: 25003306 PMCID: PMC4152385.

Samarasinghe RA, Witchel SF, DeFranco DB (2012).  Cooperativity and complementarity: Synergies in non-classical and classical glucocorticoid signaling. Cell Cycle 11, 2819-2827. PMID: 22801547, PMCID: PMC3419059

Trainee Name: Jason Sanders
Trainee: Past
Faculty Member: Newman, Anne B.Sanders JL, Cauley JA, Boudreau RM, Zmuda JM, Strotmeyer ES, Opresko PL, Hsueh WC, Ca
Publications:

Sanders JL, Cauley JA, Boudreau RM, Zmuda JM, Strotmeyer ES, Opresko PL, Hsueh WC, Cawthon RM, Li R, Harris TB, Kritchevsky SB, Newman AB; Health ABC Study, 2009, Leukocyte Telomere Length Is Not Associated With BMD, Osteoporosis, or Fracture in Older Adults: Results From the Health, Aging and Body Composition Study, J Bone Miner Res, 24(9):1531-6.

Sanders JL, Boudreau RM, Cappola AR, Arnold AM, Robbins J, Cushman M, Newman AB, 2010, Cardiovascular disease is associated with greater incident dehydroepiandrosterone sulfate decline in the oldest old: the cardiovascular health study all stars study, J Am Geriatr Soc, 58(3):421-6.

Sanders JL, Cappola AR, Arnold AM, Boudreau RM, Chaves PH, Robbins J, Cushman M, Newman AB, 2010, Concurrent change in dehydroepiandrosterone sulfate and functional performance in the oldest old: results from the Cardiovascular Health Study All Stars study, J Gerontol A Biol Sci Med Sci, 65(9):976-81.

Sanders JL, Boudreau RM, Fried LP, Walston JD, Harris TB, Newman AB, 2011, Measurement of organ structure and function enhances understanding of the physiological basis of frailty: the Cardiovascular Health Study, J Am Geriatr Soc, 59(9):1581-8.

Sanders JL, Iannaccone A, Boudreau RM, Conley YP, Opresko PL, Hsueh WC, Cummings SR, Cawthon RM, Harris TB, Nalls MA, Kritchevsky SB, Newman AB; Health ABC Study, 2011, The association of cataract with leukocyte telomere length in older adults: defining a new marker of aging, J Gerontol A Biol Sci Med Sci, 66(6):639-45.

Njajou OT, Cawthon RM, Blackburn EH, Harris TB, Li R, Sanders JL, Newman AB, Nalls M, Cummings SR, Hsueh WC, 2012, Shorter telomeres are associated with obesity and weight gain in the elderly, Int J Obes (Lond), 36(9):1176-9.

Sanders JL, Boudreau RM, Penninx BW, Simonsick EM, Kritchevsky SB, Satterfield S, Harris TB, Bauer DC, Newman AB; Health ABC Study, 2012, Association of a Modified Physiologic Index with mortality and incident disability: the Health, Aging, and Body Composition study, J Gerontol A Biol Sci Med Sci, 67(12):1439-46.

Sanders JL, Fitzpatrick AL, Boudreau RM, Arnold AM, Aviv A, Kimura M, Fried LF, Harris TB, Newman AB, 2012, Leukocyte telomere length is associated with noninvasively measured age-related disease: The Cardiovascular Health Study, J Gerontol A Biol Sci Med Sci, 67(4):409-16.

ASPREE Investigator Group [1,541 collaborators, including Sanders J], 2013, Study design of ASPirin in Reducing Events in the Elderly (ASPREE): a randomized, controlled trial, Contemp Clin Trials, 36(2):555-64.

Sanders JL, Newman AB, 2013, Telomere length in epidemiology: a biomarker of aging, age-related disease, both, or neither?, Epidemiol Rev, 35:112-31.

Sebastiani P, Sun FX, Andersen SL, Lee JH, Wojczynski MK, Sanders JL, Yashin A, Newman AB, Perls TT, 2013, Families Enriched for Exceptional Longevity also have Increased Health-Span: Findings from the Long Life Family Study, Front Public Health, 1:38.

Elbers CC, Garcia ME, Kimura M, Cummings SR, Nalls MA, Newman AB, Park V, Sanders JL, Tranah GJ, Tishkoff SA, Harris TB, Aviv A, 2014, Comparison between southern blots and qPCR analysis of leukocyte telomere length in the health ABC study, J Gerontol A Biol Sci Med Sci, 69(5):527-31.

Odden MC, Yee LM, Arnold AM, Sanders JL, Hirsch C, deFilippi C, Kizer JR, Inzitari M, Newman AB, 2014, Subclinical vascular disease burden and longer survival, J Am Geriatr Soc, 62(9):1692-8.

Sanders JL, Ding V, Arnold AM, Kaplan RC, Cappola AR, Kizer JR, Boudreau RM, Cushman M, Newman AB, 2014, Do changes in circulating biomarkers track with each other and with functional changes in older adults?, J Gerontol A Biol Sci Med Sci, 69(2):174-81.

Sanders JL, Minster RL, Barmada MM, Matteini AM, Boudreau RM, Christensen K, Mayeux R, Borecki IB, Zhang Q, Perls T, Newman AB, 2014, Heritability of and mortality prediction with a longevity phenotype: the healthy aging index, J Gerontol A Biol Sci Med Sci, 69(4):479-85.

Thyagarajan B, Wojczynski M, Minster RL, Sanders J, Barral S, Christiansen L, Barr RG, Newman A; CHARGE consortium, SpiroMeta consortium, 2014, Genetic variants associated with lung function: the long life family study, Respir Res, 15:134.

Minster RL, Sanders JL, Singh J, Kammerer CM, Barmada MM, Matteini AM, Zhang Q, Wojczynski MK, Daw EW, Brody JA, Arnold AM, Lunetta KL, Murabito JM, Christensen K, Perls TT, Province MA, Newman AB, 2015, Genome-Wide Association Study and Linkage Analysis of the Healthy Aging Index, J Gerontol A Biol Sci Med Sci, 70(8):1003-8.

Rosso AL, Sanders JL, Arnold AM, Boudreau RM, Hirsch CH, Carlson MC, Rosano C, Kritchevsky SB, Newman AB, 2015, Multisystem physiologic impairments and changes in gait speed of older adults, J Gerontol A Biol Sci Med Sci, 70(3):319-24.

Sanders JL, Newman AB. Telomere length in epidemiology: a biomarker of aging, age-related disease, both, or neither? Epidemiol Rev. 2013;35(1):112-31. doi: 10.1093/epirev/mxs008. Epub 2013 Jan 9. PMID: 23302541; PMCID: PMC4707879.

Sanders JL, Singh J, Minster RL, Walston JD, Matteini AM, Christensen K, Mayeux R, Borecki IB, Perls T, Newman AB; Long Life Family Study Research Group. Association Between Mortality and Heritability of the Scale of Aging Vigor in Epidemiology. J Am Geriatr Soc. 2016 Aug;64(8):1679-83. doi: 10.1111/jgs.14190. Epub 2016 Jun 13. PMID: 27294813; PMCID: PMC4988884.

Sanders JL, Guo W, O'Meara ES, Kaplan RC, Pollak MN, Bartz TM, Newman AB, Fried LP, Cappola AR. Trajectories of IGF-I Predict Mortality in Older Adults: The Cardiovascular Health Study. J Gerontol A Biol Sci Med Sci. 2018 Jun 14;73(7):953-959. doi: 10.1093/gerona/glx143. PMID: 28977343; PMCID: PMC6001890.

Wu C, Smit E, Sanders JL, Newman AB, Odden MC. A Modified Healthy Aging Index and Its Association with Mortality: The National Health and Nutrition Examination Survey, 1999-2002. J Gerontol A Biol Sci Med Sci. 2017 Oct 1;72(10):1437-1444. doi: 10.1093/gerona/glw334. PMID: 28329253; PMCID: PMC5861904.

O'Connell MDL, Marron MM, Boudreau RM, Canney M, Sanders JL, Kenny RA, Kritchevsky SB, Harris TB, Newman AB. Mortality in Relation to Changes in a Healthy Aging Index: The Health, Aging, and Body Composition Study. J Gerontol A Biol Sci Med Sci. 2019 Apr 23;74(5):726-732. doi: 10.1093/gerona/gly114. PMID: 29733331; PMCID: PMC6477637.

Sanders JL, Arnold AM, Boudreau RM, Hirsch CH, Kizer JR, Kaplan RC, Cappola AR, Cushman M, Jacob ME, Kritchevsky SB, Newman AB. Association of Biomarker and Physiologic Indices With Mortality in Older Adults: Cardiovascular Health Study. J Gerontol A Biol Sci Med Sci. 2019 Jan 1;74(1):114-120. doi: 10.1093/gerona/gly075. PMID: 29659743; PMCID: PMC6298182.

Sanders JL, Arnold AM, Hirsch CH, Thielke SM, Kim D, Mukamal KJ, Kizer JR, Ix JH, Kaplan RC, Kritchevsky SB, Newman AB. Effects of Disease Burden and Functional Adaptation on Morbidity and Mortality on Older Adults. J Am Geriatr Soc. 2016 Jun;64(6):1242-9. doi: 10.1111/jgs.14163. PMID: 27321602; PMCID: PMC4922749.

Marron MM, Harris TB, Boudreau RM, Clish CB, Moore SC, Murphy RA, Murthy VL, Sanders JL, Shah RV, Tseng GC, Wendell SG, Zmuda JM, Newman AB. Metabolites Associated with Vigor to Frailty Among Community-Dwelling Older Black Men. Metabolites. 2019 Apr 30;9(5):83. doi: 10.3390/metabo9050083. PMID: 31052232; PMCID: PMC6572139.

Minster RL, Sanders JL, Singh J, Kammerer CM, Barmada MM, Matteini AM, Zhang Q, Wojczynski MK, Daw EW, Brody JA, Arnold AM, Lunetta KL, Murabito JM, Christensen K, Perls TT, Province MA, Newman AB. Genome-Wide Association Study and Linkage Analysis of the Healthy Aging Index. J Gerontol A Biol Sci Med Sci. 2015 Aug;70(8):1003-8. doi: 10.1093/gerona/glv006. Epub 2015 Mar 10. PMID: 25758594; PMCID: PMC4506316.

Trainee Name: Aaron Secrest
Trainee: Past
Faculty Member: Orchard, Trevor
Publications:

Costacou T, Secrest AM, Ferrell RE, Orchard TJ. Haptoglobin genotype and cerebrovascular disease incidence in type 1 diabetes. Diab Vasc Dis Res. 2014 Sep;11(5):335-42. doi: 10.1177/1479164114539713. Epub 2014 Jul 3. PMID: 24994788; PMCID: PMC4134420.

Shay CM, Secrest AM, Miller RG, Strotmeyer ES, Goodpaster BH, Kelsey SF, Orchard TJ. Femoral-gluteal adiposity is not associated with insulin sensitivity in type 1 diabetes. Diabet Med. 2012 Nov;29(11):1407-11. doi: 10.1111/j.1464-5491.2012.03728.x. PMID: 22672227.

Washington RE, Orchard TJ, Arena VC, LaPorte RE, Secrest AM, Tull ES. All-cause mortality in a population-based type 1 diabetes cohort in the U.S. Virgin Islands. Diabetes Res Clin Pract. 2014 Mar;103(3):504-9. doi: 10.1016/j.diabres.2013.12.014. Epub 2013 Dec 27. PMID: 24439208; PMCID: PMC4516118.

Trainee Name: Samuel Shin
Trainee: Past
Faculty Member: Dixon, Edward
Publications:

Shin SS, Bray ER, Zhang CQ, Dixon CE. Traumatic brain injury reduces striatal tyrosine hydroxylase activity and potassium-evoked dopamine release in rats. Brain Res. 2011 Jan 19;1369:208-15. doi: 10.1016/j.brainres.2010.10.096. Epub 2010 Nov 1. PMID: 21047500; PMCID: PMC3014391.

Shin SS, Dixon CE. Alterations in Cholinergic Pathways and Therapeutic Strategies Targeting Cholinergic System after Traumatic Brain Injury. J Neurotrauma. 2015 Oct 1;32(19):1429-40. doi: 10.1089/neu.2014.3445. Epub 2015 Jun 29. PMID: 25646580; PMCID: PMC4842943.

Shin SS, Grandhi R, Henchir J, Yan HQ, Badylak SF, Dixon CE. Neuroprotective effects of collagen matrix in rats after traumatic brain injury. Restor Neurol Neurosci. 2015;33(2):95-104. doi: 10.3233/RNN-140430. PMID: 25624423.

Yan HQ, Shin SS, Ma X, Li Y, Dixon CE. Differential effect of traumatic brain injury on the nuclear factor of activated T Cells C3 and C4 isoforms in the rat hippocampus. Brain Res. 2014 Feb 22;1548:63-72. doi: 10.1016/j.brainres.2013.12.028. Epub 2013 Dec 31. PMID: 24389074; PMCID: PMC4017626.

Kochanek PM, Dixon CE, Shellington DK, Shin SS, Bayır H, Jackson EK, Kagan VE, Yan HQ, Swauger PV, Parks SA, Ritzel DV, Bauman R, Clark RS, Garman RH, Bandak F, Ling G, Jenkins LW. Screening of biochemical and molecular mechanisms of secondary injury and repair in the brain after experimental blast-induced traumatic brain injury in rats. J Neurotrauma. 2013 Jun 1;30(11):920-37. doi: 10.1089/neu.2013.2862. Epub 2013 Jun 5. PMID: 23496248; PMCID: PMC5586163.

Shin SS, Bales JW, Yan HQ, Kline AE, Wagner AK, Lyons-Weiler J, Dixon CE. The effect of environmental enrichment on substantia nigra gene expression after traumatic brain injury in rats. J Neurotrauma. 2013 Feb 15;30(4):259-70. doi: 10.1089/neu.2012.2462. Epub 2013 Feb 5. PMID: 23094804; PMCID: PMC3579325.

Shin SS, Bray ER, Dixon CE. Effects of nicotine administration on striatal dopamine signaling after traumatic brain injury in rats. J Neurotrauma. 2012 Mar 20;29(5):843-50. doi: 10.1089/neu.2011.1966. Epub 2011 Oct 24. PMID: 21815786; PMCID: PMC3303095.

Shin SS, Dixon CE. Oral fish oil restores striatal dopamine release after traumatic brain injury. Neurosci Lett. 2011 Jun 8;496(3):168-71. doi: 10.1016/j.neulet.2011.04.009. Epub 2011 Apr 14. PMID: 21514362; PMCID: PMC5271597.

Shin SS, Dixon CE. Targeting α7 nicotinic acetylcholine receptors: a future potential for neuroprotection from traumatic brain injury. Neural Regen Res. 2015 Oct;10(10):1552-4. doi: 10.4103/1673-5374.165309. PMID: 26692836; PMCID: PMC4660732.

Shin SS, Pathak S, Presson N, Bird W, Wagener L, Schneider W, Okonkwo DO, Fernandez-Miranda JC. Detection of white matter injury in concussion using high-definition fiber tractography. Prog Neurol Surg. 2014;28:86-93. doi: 10.1159/000358767. Epub 2014 Jun 6. PMID: 24923395.

Shin SS, Dixon CE, Okonkwo DO, Richardson RM. Neurostimulation for traumatic brain injury. J Neurosurg. 2014 Nov;121(5):1219-31. doi: 10.3171/2014.7.JNS131826. Epub 2014 Aug 29. PMID: 25170668.

Shin SS, Verstynen T, Pathak S, Jarbo K, Hricik AJ, Maserati M, Beers SR, Puccio AM, Boada FE, Okonkwo DO, Schneider W. High-definition fiber tracking for assessment of neurological deficit in a case of traumatic brain injury: finding, visualizing, and interpreting small sites of damage. J Neurosurg. 2012 May;116(5):1062-9. doi: 10.3171/2012.1.JNS111282. Epub 2012 Mar 2. PMID: 22381003.

Bonfield CM, Shin SS, Kanter AS. Helmets, head injury and concussion in sport. Phys Sportsmed. 2015 Jul;43(3):236-46. doi: 10.1080/00913847.2015.1039922. Epub 2015 Apr 27. PMID: 25913712.

Ricks CB, Shin SS, Becker C, Grandhi R. Extracellular matrices, artificial neural scaffolds and the promise of neural regeneration. Neural Regen Res. 2014 Sep 1;9(17):1573-7. doi: 10.4103/1673-5374.141778. PMID: 25368641; PMCID: PMC4211196.

Shin SS, Tormenti MJ, Paluzzi A, Rothfus WE, Chang YF, Zainah H, Fernandez-Miranda JC, Snyderman CH, Challinor SM, Gardner PA. Endoscopic endonasal approach for growth hormone secreting pituitary adenomas: outcomes in 53 patients using 2010 consensus criteria for remission. Pituitary. 2013 Dec;16(4):435-44. doi: 10.1007/s11102-012-0440-6. PMID: 23179961.

Liu X, Kano H, Kondziolka D, Park KJ, Iyer A, Shin S, Niranjan A, Flickinger JC, Lunsford LD. Gamma knife stereotactic radiosurgery for drug resistant or intolerant invasive prolactinomas. Pituitary. 2013 Mar;16(1):68-75. doi: 10.1007/s11102-012-0376-x. PMID: 22302560.

Shin SS, Gardner PA, Stefko ST, Madhok R, Fernandez-Miranda JC, Snyderman CH. Endoscopic endonasal approach for nonvestibular schwannomas. Neurosurgery. 2011 Nov;69(5):1046-57; discussion 1057. doi: 10.1227/NEU.0b013e3182287bb9. PMID: 21673609.

Hwang M, Marovich R, Shin SS, Chi D, Branstetter BF 4th. Optimizing CT for the evaluation of vestibular aqueduct enlargement: Inter-rater reproducibility and predictive value of reformatted CT measurements. J Otol. 2015 Mar;10(1):13-17. doi: 10.1016/j.joto.2015.07.004. Epub 2015 Aug 22. PMID: 29937776; PMCID: PMC6002559.

Mousavi SH, Niranjan A, Huang MJ, Laghari FJ, Shin SS, Mindlin JL, Flickinger JC, Lunsford LD. Early radiosurgery provides superior pain relief for trigeminal neuralgia patients. Neurology. 2015 Dec 15;85(24):2159-65. doi: 10.1212/WNL.0000000000002216. Epub 2015 Nov 11. PMID: 26561286.

Trainee Name: Gaurav Shukla
Trainee: Past
Faculty Member: Stetten, George
Publications:

Shukla G, Klatzky RL, Wu B, Wang B, Galeotti J, Chapmann B, Stetten G. Integrating images from a moveable tracked display of three-dimensional data. Cogn Res Princ Implic. 2017;2(1):34. doi: 10.1186/s41235-017-0069-0. Epub 2017 Aug 23. PMID: 28890919; PMCID: PMC5569642.

Amesur NB, Wang DC, Chang W, Weiser D, Klatzky R, Shukla G, Stetten GD. Peripherally inserted central catheter placement using the Sonic Flashlight. J Vasc Interv Radiol. 2009 Oct;20(10):1380-3. doi: 10.1016/j.jvir.2009.07.002. Epub 2009 Aug 21. PMID: 19699661; PMCID: PMC2760099.

Chen ML, Shukla G, Jackman SV, Tsao AK, Smaldone MC, Ost MC, Stetten GD, Averch TD. Real-time tomographic reflection in facilitating percutaneous access to the renal collecting system. J Endourol. 2011 May;25(5):743-5. doi: 10.1089/end.2010.0375. Epub 2011 Apr 11. PMID: 21480789.

Wang D, Amesur N, Shukla G, Bayless A, Weiser D, Scharl A, Mockel D, Banks C, Mandella B, Klatzky R, Stetten G. Peripherally inserted central catheter placement with the sonic flashlight: initial clinical trial by nurses. J Ultrasound Med. 2009 May;28(5):651-6. doi: 10.7863/jum.2009.28.5.651. PMID: 19389904; PMCID: PMC2869215.

Kim H, Beriwal S, Huq MS, Kannan N, Shukla G, Houser C. Evaluation of set-up uncertainties with daily kilovoltage image guidance in external beam radiation therapy for gynaecological cancers. Clin Oncol (R Coll Radiol). 2012 Mar;24(2):e39-45. doi: 10.1016/j.clon.2011.09.007. Epub 2011 Sep 22. PMID: 21943780.

Trainee Name: Daniel Simmonds
Trainee: Past
Faculty Member: Luna, Beatriz
Publications:

Simmonds D, Goldberg M and Luna B, 2014, Building the roads in the city of your brain, Front Young Minds. 2:17.

Simmonds DJ, Hallquist MN, Asato M, Luna B. Developmental stages and sex differences of white matter and behavioral development through adolescence: a longitudinal diffusion tensor imaging (DTI) study. Neuroimage. 2014 May 15;92:356-68. doi: 10.1016/j.neuroimage.2013.12.044. Epub 2013 Dec 31. PMID: 24384150; PMCID: PMC4301413.

Lynn AC, Padmanabhan A, Simmonds D, Foran W, Hallquist MN, Luna B, O'Hearn K. Functional connectivity differences in autism during face and car recognition: underconnectivity and atypical age-related changes. Dev Sci. 2016 Oct 16. doi: 10.1111/desc.12508. [Epub ahead of print]

Tervo-Clemmens B, Simmonds D, Calabro FJ, Montez DF, Lekht JA, Day NL, Richardson GA, Luna B. Early Cannabis Use and Neurocognitive Risk: A Prospective Functional Neuroimaging Study. Biol Psychiatry Cogn Neurosci Neuroimaging. 2018 Aug;3(8):713-725. doi: 10.1016/j.bpsc.2018.05.004. Epub 2018 May 29. PMID: 30033100; PMCID: PMC6561344.

Tervo-Clemmens B, Simmonds D, Calabro FJ, Day NL, Richardson GA, Luna B. Adolescent cannabis use and brain systems supporting adult working memory encoding, maintenance, and retrieval. Neuroimage. 2018 Apr 1;169:496-509. doi: 10.1016/j.neuroimage.2017.12.041. Epub 2017 Dec 15. PMID: 29253654; PMCID: PMC6537905.

Jalbrzikowski M, Murty VP, Stan PL, Saifullan J, Simmonds D, Foran W, Luna B. Differentiating between clinical and behavioral phenotypes in first-episode psychosis during maintenance of visuospatial working memory. Schizophr Res. 2018 Jul;197:357-364. doi: 10.1016/j.schres.2017.11.012. Epub 2017 Nov 11. PMID: 29137828; PMCID: PMC5948111.

Simmonds DJ, Hallquist MN, Luna B. Protracted development of executive and mnemonic brain systems underlying working memory in adolescence: A longitudinal fMRI study. Neuroimage. 2017 Aug 15;157:695-704. doi: 10.1016/j.neuroimage.2017.01.016. Epub 2017 Apr 27. PMID: 28456583; PMCID: PMC6130258.

Trainee Name: Rachelle Stopczynski Gupta
Trainee: Past
Faculty Member: Albers, Kathryn M.
Publications:

Morris HM, Stopczynski RE, Lewis DA. NPY mRNA expression in the prefrontal cortex: Selective reduction in the superficial white matter of subjects with schizoaffective disorder. Schizophr Res. 2009 Dec;115(2-3):261-9. doi: 10.1016/j.schres.2009.09.014. Epub 2009 Oct 4. PMID: 19804960; PMCID: PMC2783408.

Stopczynski RE, Poloskey SL, Haber SN. Cell proliferation in the striatum during postnatal development: preferential distribution in subregions of the ventral striatum. Brain Struct Funct. 2008 Sep;213(1-2):119-27. doi: 10.1007/s00429-008-0185-1. Epub 2008 Jun 17. PMID: 18560887; PMCID: PMC4455935.See comment in PubMed Commons below

Rickels MR, Bellin M, Toledo FG, Robertson RP, Andersen DK, Chari ST, Brand R, Frulloni L, Anderson MA, Whitcomb DC; PancreasFest Recommendation Conference Participants. Detection, evaluation and treatment of diabetes mellitus in chronic pancreatitis: recommendations from PancreasFest 2012. Pancreatology. 2013 Jul-Aug;13(4):336-42. doi: 10.1016/j.pan.2013.05.002. Epub 2013 May 17. PMID: 23890130; PMCID: PMC3830751.

Bellin MD, Freeman ML, Gelrud A, Slivka A, Clavel A, Humar A, Schwarzenberg SJ, Lowe ME, Rickels MR, Whitcomb DC, Matthews JB; PancreasFest Recommendation Conference Participants, Amann S, Andersen DK, Anderson MA, Baillie J, Block G, Brand R, Chari S, Cook M, Cote GA, Dunn T, Frulloni L, Greer JB, Hollingsworth MA, Kim KM, Larson A, Lerch MM, Lin T, Muniraj T, Robertson RP, Sclair S, Singh S, Stopczynski R, Toledo FG, Wilcox CM, Windsor J, Yadav D. Total pancreatectomy and islet autotransplantation in chronic pancreatitis: recommendations from PancreasFest. Pancreatology. 2014 Jan-Feb;14(1):27-35. doi: 10.1016/j.pan.2013.10.009. Epub 2013 Nov 13. PMID: 24555976; PMCID: PMC4058640.

Stopczynski RE, Normolle DP, Hartman DJ, Ying H, DeBerry JJ, Bielefeldt K, Rhim AD, DePinho RA, Albers KM, Davis BM. Neuroplastic changes occur early in the development of pancreatic ductal adenocarcinoma. Cancer Res. 2014 Mar 15;74(6):1718-27. doi: 10.1158/0008-5472.CAN-13-2050. Epub 2014 Jan 21. PMID: 24448244; PMCID: PMC4036226.

Trainee Name: Eric Strobl
Trainee: Past
Faculty Member: Visweswaran, Shyam
Publications:

Strobl EV, Eack SM, Swaminathan V, Visweswaran S. Predicting the risk of psychosis onset: Advances and prospects. Early Intervention in Psychiatry. 2012 Nov;6(4):368-79. PMID: 22776068 PMCID: PMC3470783

Strobl EV, Visweswaran S. Markov boundary discovery with ridge regularized linear models. Journal of Causal Inference. 2016 Mar; 4(1):31-48. PMID: 27170915 PMCID: PMC4861166

Strobl EV, Visweswaran S, Spirtes PL. Fast causal inference with non-random missingness by test-wise deletion. International Journal of Data Science and Analytics. 2018 Aug; 6(1):47-62. PMID:31321289 PMCID: PMC6638553

Strobl E, Zhang K, Visweswaran S. Approximate kernel-based conditional independence tests for fast non-parametric causal discovery. Journal of Causal Inference. 2019 Mar; 4(1):31-48.

Strobl EV, Spirtes P, Visweswaran S. Estimating and controlling the False Discovery Rate of the PC algorithm using edge-specific p-values. ACM Transactions on Intelligent Systems and Technology. 2019 Oct 10;10(5):46.

Strobl EV, Visweswaran S. Deep multiple kernel learning. In: Proceedings of the 12th International Conference on Machine Learning and Applications (ICMLA'13). 2013 Dec 4; 2013:414-17.

Strobl EV, Visweswaran S. Markov blanket discovery using the conditional Hilbert Schmidt Independence Criterion. In: Proceedings of the NIPS 2013 Workshop on Large-scale Experiment Design and Inference of Causal Mechanisms, Lake Tahoe, NV. 2013 Dec 9.

Strobl EV, Visweswaran S. Dependence versus conditional dependence in local causal discovery from gene expression data. arXiv preprint arXiv:1407.7566, 2014.

Strobl EV, Visweswaran S. Dirac delta regression: Conditional density estimation with clinical trials. arXiv preprint arXiv:1905.10330, 2019.

Trainee Name: Joshua Sturm
Trainee: Past
Faculty Member: Kandler, Karl
Publications:

Sturm J, Nguyen T, Kandler K, 2014, Development of intrinsic connectivity in the central nucleus of the mouse inferior colliculus, J Neurosci, 34(45):15032-46.

Sturm JJ, Nguyen T, Kandler K. Mapping Auditory Synaptic Circuits with Photostimulation of Caged Glutamate. Methods Mol Biol. 2016;1427:525-37.

Sturm JS, Zhang-Hooks Y-Z, Roos H, Nguyen T, and Kandler K, Noise trauma induced behavioral gap detection deficits correlate with reorganization of excitatory and inhibitory local circuits in the inferior colliculus and are prevented by acoustic enrichment. J Neurosci. 37(26):6314-6330.

Sturm J, Nguyen TD, Kandler K (2014) Development of intrinsic connectivity in the central nucleus of the mouse inferior colliculus. J. Neuroscience, 34:15032-46

Trainee Name: David Sturman
Trainee: Past
Faculty Member: Moghaddam, Bita
Publications:

Sturman DA, Moghaddam B. Striatum processes reward differently in adolescents versus adults. Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1719-24. doi: 10.1073/pnas.1114137109. Epub 2012 Jan 17. PMID: 22307637; PMCID: PMC3277117.

Sturman DA, Moghaddam B. The neurobiology of adolescence: changes in brain architecture, functional dynamics, and behavioral tendencies. Neurosci Biobehav Rev. 2011 Aug;35(8):1704-12. doi: 10.1016/j.neubiorev.2011.04.003. Epub 2011 Apr 15. PMID: 21527288; PMCID: PMC3222328.

Sturman DA, Mandell DR, Moghaddam B. Adolescents exhibit behavioral differences from adults during instrumental learning and extinction. Behav Neurosci. 2010 Feb;124(1):16-25. doi: 10.1037/a0018463. PMID: 20141277; PMCID: PMC2871391.

Sturman DA, Moghaddam B. Reduced neuronal inhibition and coordination of adolescent prefrontal cortex during motivated behavior. J Neurosci. 2011 Jan 26;31(4):1471-8. doi: 10.1523/JNEUROSCI.4210-10.2011. PMID: 21273431; PMCID: PMC3257819.

Trainee Name: Aaron Sun, MD, PhD
Trainee: Past
Faculty Member: Rocky Tuan, PhD
Publications:

Sun AX, Lin H, Fritch MR, Shen H, Alexander PG, DeHart M, Tuan RS. Chondrogenesis of human bone marrow mesenchymal stem cells in 3-dimensional, photocrosslinked hydrogel constructs: Effect of cell seeding density and material stiffness. Acta Biomater. 2017 Aug;58:302-311. doi: 10.1016/j.actbio.2017.06.016. Epub 2017 Jun 10. PMID: 28611002; PMCID: PMC5813286.

Whitehead A, Zhang Y, McCabe Dunn J, Sherer EC, Lam YH, Stelmach J, Sun A, Shiroda M, Orr RK, Waddell ST, Raghavan S. 2017. Selective Formation of Functionalized α-Quaternary Malononitriles toward 5,5-Disubstituted Pyrrolopyrimidinones. Organic Letters. 4448-4451. PMID: 28812897.

Sun AX, Numpaisal P, Gottardi R, Shen H, Yang G, Tuan RS. 2016. Cell and Biomimetic Scaffold-Based Approaches for Cartilage Regeneration. Operative Techniques in orthopaedics. 135-146. PMID:

Londono R, Sun AX, Tuan RS, Lozito TP. TISSUE REPAIR AND EPIMORPHIC REGENERATION: AN OVERVIEW. Curr Pathobiol Rep. 2018 Mar;6(1):61-69. doi: 10.1007/s40139-018-0161-2. Epub 2018 Feb 4. PMID: 29967714; PMCID: PMC6025457.

Deng Y, Sun AX, Overholt KJ, Yu GZ, Fritch MR, Alexander PG, Shen H, Tuan RS, Lin H. Enhancing chondrogenesis and mechanical strength retention in physiologically relevant hydrogels with incorporation of hyaluronic acid and direct loading of TGF-β. Acta Biomater. 2019 Jan 1;83:167-176. doi: 10.1016/j.actbio.2018.11.022. Epub 2018 Nov 17. PMID: 30458242; PMCID: PMC6733255.

Shen H , Lin H , Sun AX, Song S , Zhang Z , Dai J , Tuan RS . Chondroinductive factor-free chondrogenic differentiation of human mesenchymal stem cells in graphene oxide-incorporated hydrogels. J Mater Chem B. 2018 Feb 14;6(6):908-917. doi: 10.1039/c7tb02172k. Epub 2018 Jan 23.

Sun AX, Londono R, Hudnall ML, Tuan RS, Lozito TP. Differences in neural stem cell identity and differentiation capacity drive divergent regenerative outcomes in lizards and salamanders. Proc Natl Acad Sci U S A. 2018 Aug 28;115(35):E8256-E8265. doi: 10.1073/pnas.1803780115. Epub 2018 Aug 13. PMID: 30104374; PMCID: PMC6126763.

Sun AX, Prest TA, Fowler JR, Brick RM, Gloss KM, Li X, DeHart M, Shen H, Yang G, Brown BN, Alexander PG, Tuan RS. Conduits harnessing spatially controlled cell-secreted neurotrophic factors improve peripheral nerve regeneration. Biomaterials. 2019 May;203:86-95. doi: 10.1016/j.biomaterials.2019.01.038. Epub 2019 Feb 19.

Brick RM, Sun AX, Tuan RS. Neurotrophically Induced Mesenchymal Progenitor Cells Derived from Induced Pluripotent Stem Cells Enhance Neuritogenesis via Neurotrophin and Cytokine Production. Stem Cells Transl Med. 2018 Jan;7(1):45-58. doi: 10.1002/sctm.17-0108. Epub 2017 Dec 7. PMID: 29215199; PMCID: PMC5746147.

Sun AX, Lin H, Fritch MR, Shen H, Alexander PG, DeHart M, Tuan RS. Chondrogenesis of human bone marrow mesenchymal stem cells in 3-dimensional, photocrosslinked hydrogel constructs: Effect of cell seeding density and material stiffness. Acta Biomater. 2017 Aug;58:302-311. doi: 10.1016/j.actbio.2017.06.016. Epub 2017 Jun 10.

Shen H, Lin H, Sun AX, Song S, Wang B, Yang Y, Dai J, Tuan RS. Acceleration of chondrogenic differentiation of human mesenchymal stem cells by sustained growth factor release in 3D graphene oxide incorporated hydrogels. Acta Biomater. 2020 Mar 15;105:44-55. doi: 10.1016/j.actbio.2020.01.048. Epub 2020 Feb 5.

Sun AX, Lin H, Beck AM, Kilroy EJ, Tuan RS. Projection Stereolithographic Fabrication of Human Adipose Stem Cell-Incorporated Biodegradable Scaffolds for Cartilage Tissue Engineering. Front Bioeng Biotechnol. 2015 Aug 18;3:115. doi: 10.3389/fbioe.2015.00115. PMID: 26347860; PMCID: PMC4539543.

Trainee Name: David Svilar
Trainee: Past
Faculty Member: Sobol, Robert
Publications:

Li J, Svilar D, McClellan S, Kim JH, Ahn EE, Vens C, Wilson DM 3rd, Sobol RW. DNA Repair Molecular Beacon assay: a platform for real-time functional analysis of cellular DNA repair capacity. Oncotarget. 2018 Aug 3;9(60):31719-31743. doi: 10.18632/oncotarget.25859. PMID: 30167090; PMCID: PMC6114979.

Fang Q, Inanc B, Schamus S, Wang XH, Wei L, Brown AR, Svilar D, Sugrue KF, Goellner EM, Zeng X, Yates NA, Lan L, Vens C, Sobol RW. HSP90 regulates DNA repair via the interaction between XRCC1 and DNA polymerase β. Nat Commun. 2014 Nov 26;5:5513. doi: 10.1038/ncomms6513. PMID: 25423885; PMCID: PMC4246423.

Svilar D, Dyavaiah M, Brown AR, Tang JB, Li J, McDonald PR, Shun TY, Braganza A, Wang XH, Maniar S, St Croix CM, Lazo JS, Pollack IF, Begley TJ, Sobol RW. Alkylation sensitivity screens reveal a conserved cross-species functionome. Mol Cancer Res. 2012 Dec;10(12):1580-96. doi: 10.1158/1541-7786.MCR-12-0168. Epub 2012 Oct 4. PMID: 23038810; PMCID: PMC3877719.

Svilar D, Vens C, Sobol RW. Quantitative, real-time analysis of base excision repair activity in cell lysates utilizing lesion-specific molecular beacons. J Vis Exp. 2012 Aug 6;(66):e4168. doi: 10.3791/4168. PMID: 22895410; PMCID: PMC3476757.

Goellner EM, Svilar D, Almeida KH, Sobol RW. Targeting DNA polymerase ß for therapeutic intervention. Curr Mol Pharmacol. 2012 Jan;5(1):68-87. PMID: 22122465; PMCID: PMC3894524.

Tang JB, Svilar D, Trivedi RN, Wang XH, Goellner EM, Moore B, Hamilton RL, Banze LA, Brown AR, Sobol RW. N-methylpurine DNA glycosylase and DNA polymerase beta modulate BER inhibitor potentiation of glioma cells to temozolomide. Neuro Oncol. 2011 May;13(5):471-86. doi: 10.1093/neuonc/nor011. Epub 2011 Mar 3. PMID: 21377995; PMCID: PMC3093332.

Tang JB, Goellner EM, Wang XH, Trivedi RN, St Croix CM, Jelezcova E, Svilar D, Brown AR, Sobol RW. Bioenergetic metabolites regulate base excision repair-dependent cell death in response to DNA damage. Mol Cancer Res. 2010 Jan;8(1):67-79. doi: 10.1158/1541-7786.MCR-09-0411. Epub 2010 Jan 12. PMID: 20068071; PMCID: PMC2808464.

Svilar D, Goellner EM, Almeida KH, Sobol RW. Base excision repair and lesion-dependent subpathways for repair of oxidative DNA damage. Antioxid Redox Signal. 2011 Jun 15;14(12):2491-507. doi: 10.1089/ars.2010.3466. Epub 2010 Oct 28. PMID: 20649466; PMCID: PMC3096496.

Mutamba JT, Svilar D, Prasongtanakij S, Wang XH, Lin YC, Dedon PC, Sobol RW, Engelward BP. XRCC1 and base excision repair balance in response to nitric oxide. DNA Repair (Amst). 2011 Dec 10;10(12):1282-93. doi: 10.1016/j.dnarep.2011.10.008. Epub 2011 Oct 29. PMID: 22041025; PMCID: PMC3593656.

Iyer P, Srinivasan A, Singh SK, Mascara GP, Zayitova S, Sidone B, Fouquerel E, Svilar D, Sobol RW, Bobola MS, Silber JR, Gold B. Synthesis and characterization of DNA minor groove binding alkylating agents. Chem Res Toxicol. 2013 Jan 18;26(1):156-68. doi: 10.1021/tx300437x. Epub 2012 Dec 26. PMID: 23234400; PMCID: PMC3618862.

Nagaria P, Svilar D, Brown AR, Wang XH, Sobol RW, Wyatt MD. SMUG1 but not UNG DNA glycosylase contributes to the cellular response to recovery from 5-fluorouracil induced replication stress. Mutat Res. 2013 Mar-Apr;743-744:26-32. doi: 10.1016/j.mrfmmm.2012.12.001. Epub 2012 Dec 17. PMID: 23253900; PMCID: PMC3616158.

Trainee Name: Adrienne Taren
Trainee: Past
Faculty Member: Tarr, Michael J.
Publications:

Taren AA, Creswell JD, Gianaros PJ, 2013, Dispositional mindfulness co-varies with smaller amygdala and caudate volumes in community adults, PLoS One, 8(5):e64574.

Taren AA, Gianaros PJ, Greco CM, Lindsay EK, Fairgrieve A, Brown KW, Rosen RK, Ferris JL, Julson E, Marsland AL, Bursley JK, Ramsburg J, David Creswell J, 2015, Mindfulness meditation training alters stress-related amygdala resting state functional connectivity: a randomized controlled trial, Soc Cogn Affect Neurosci, 2015 Jun 5. [Epub ahead of print]

Creswell JD, Taren AA, Lindsay EK, Greco CM, Gianaros PJ, Fairgrieve A, Marsland AL, Brown KW, Way BM, Rosen RK, Ferris JL. Alterations in Resting-State Functional Connectivity Link Mindfulness Meditation With Reduced Interleukin-6: A Randomized Controlled Trial. Biol Psychiatry. 2016;80(1):53-61. Epub 2016/03/30. doi: 10.1016/j.biopsych.2016.01.008. PubMed PMID: 27021514.

Taren AA, Gianaros PJ, Greco CM, Lindsay EK, Fairgrieve A, Brown KW, Rosen RK, Ferris JL, Julson E, Marsland AL, Creswell JD. Mindfulness Meditation Training and Executive Control Network Resting State Functional Connectivity: A Randomized Controlled Trial. Psychosom Med. 2017;79(6):674-83. Epub 2017/03/23. doi: 10.1097/PSY.0000000000000466. PubMed PMID: 28323668; PMCID: PMC5489372.

Trainee Name: Jeremy Tilstra
Trainee: Past
Faculty Member: Robbins, Paul
Publications:

Tilstra JS, Gaddy DF, Zhao J, Davé SH, Niedernhofer LJ, Plevy SE, Robbins PD. Pharmacologic IKK/NF-κB inhibition causes antigen presenting cells to undergo TNFα dependent ROS-mediated programmed cell death. Sci Rep. 2014 Jan 10;4:3631. doi: 10.1038/srep03631. PMID: 24406986; PMCID: PMC3887388.

Davé SH, Tilstra JS, Matsuoka K, Li F, Karrasch T, Uno JK, Sepulveda AR, Jobin C, Baldwin AS, Robbins PD, Plevy SE. Amelioration of chronic murine colitis by peptide-mediated transduction of the IkappaB kinase inhibitor NEMO binding domain peptide. J Immunol. 2007 Dec 1;179(11):7852-9. doi: 10.4049/jimmunol.179.11.7852. PMID: 18025231; PMCID: PMC3203537.

Tilstra JS, Robinson AR, Wang J, Gregg SQ, Clauson CL, Reay DP, Nasto LA, St Croix CM, Usas A, Vo N, Huard J, Clemens PR, Stolz DB, Guttridge DC, Watkins SC, Garinis GA, Wang Y, Niedernhofer LJ, Robbins PD. NF-κB inhibition delays DNA damage-induced senescence and aging in mice. J Clin Invest. 2012 Jul;122(7):2601-12. doi: 10.1172/JCI45785. Epub 2012 Jun 18. PMID: 22706308; PMCID: PMC3386805.

Tilstra JS, Clauson CL, Niedernhofer LJ, Robbins PD. NF-κB in Aging and Disease. Aging Dis. 2011 Dec;2(6):449-65. Epub 2011 Dec 2. PMID: 22396894; PMCID: PMC3295063.

Nasto LA, Seo HY, Robinson AR, Tilstra JS, Clauson CL, Sowa GA, Ngo K, Dong Q, Pola E, Lee JY, Niedernhofer LJ, Kang JD, Robbins PD, Vo NV. ISSLS prize winner: inhibition of NF-κB activity ameliorates age-associated disc degeneration in a mouse model of accelerated aging. Spine (Phila Pa 1976). 2012 Oct 1;37(21):1819-25. doi: 10.1097/BRS.0b013e31824ee8f7. Erratum in: Spine (Phila Pa 1976). 2013 Jan 1;38(1):E48. PMID: 22343279; PMCID: PMC3395770.

Davé SH, Tilstra JS, Matsuoka K, Li F, DeMarco RA, Beer-Stolz D, Sepulveda AR, Fink MP, Lotze MT, Plevy SE. Ethyl pyruvate decreases HMGB1 release and ameliorates murine colitis. J Leukoc Biol. 2009 Sep;86(3):633-43. doi: 10.1189/jlb.1008662. Epub 2009 May 19. PMID: 19454652; PMCID: PMC2735284.

Lu A, Proto JD, Guo L, Tang Y, Lavasani M, Tilstra JS, Niedernhofer LJ, Wang B, Guttridge DC, Robbins PD, Huard J. NF-κB negatively impacts the myogenic potential of muscle-derived stem cells. Mol Ther. 2012 Mar;20(3):661-8. doi: 10.1038/mt.2011.261. Epub 2011 Dec 13. PMID: 22158056; PMCID: PMC3293604.

Tilstra J, Rehman KK, Hennon T, Plevy SE, Clemens P, Robbins PD. Protein transduction: identification, characterization and optimization. Biochem Soc Trans. 2007 Aug;35(Pt 4):811-5. doi: 10.1042/BST0350811. PMID: 17635154.

Lavasani M, Robinson AR, Lu A, Song M, Feduska JM, Ahani B, Tilstra JS, Feldman CH, Robbins PD, Niedernhofer LJ, Huard J. Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model. Nat Commun. 2012 Jan 3;3:608. doi: 10.1038/ncomms1611. PMID: 22215083; PMCID: PMC3272577.

Tilstra JS, Lienesch DW. Rheumatoid Nodules. Dermatol Clin. 2015 Jul;33(3):361-71. doi: 10.1016/j.det.2015.03.004. PMID: 26143419.

Tilstra JS, Prevost N, Khera P, English JC 3rd. Scalp dermatomyositis revisited. Arch Dermatol. 2009 Sep;145(9):1062-3. doi: 10.1001/archdermatol.2009.194. PMID: 19770456.

Trainee Name: Jeffrey Walch
Trainee: Past
Faculty Member: Lakkis, Fadi
Publications:

Walch, J. M., and F. G. Lakkis. 2014. T-cell migration to vascularized organ allografts. Curr Opin Organ Transplant 19:28-32.

Walch, J. M., Q. Zeng, Q. Li, M. H. Oberbarnscheidt, R. A. Hoffman, A. L. Williams, D. M. Rothstein, W. D. Shlomchik, J. V. Kim, G. Camirand, and F. G. Lakkis. 2013. Cognate antigen directs CD8+ T cell migration to vascularized transplants. J Clin Invest 123:2663-2671.

Oberbarnscheidt, M. H., J. M. Walch, Q. Li, A. L. Williams, J. T. Walters, R. A. Hoffman, A. J. Demetris, C. Gerard, G. Camirand, and F. G. Lakkis. 2011. Memory T cells migrate to and reject vascularized cardiac allografts independent of the chemokine receptor CXCR3. Transplantation 91:827-832.

Trainee Name: Bo Wang
Trainee: Past
Faculty Member: Schuman, Joel S.
Publications:

Wang B, Lucy KA, Schuman JS, Ishikawa H, Bilonick RA, Sigal IA, Kagemann L, Lu C, Fujimoto JG, Wollstein G.. 2017. Location of the Central Retinal Vessel Trunk in the Laminar and Prelaminar Tissue of Healthy and Glaucomatous Eyes. Sci Rep. PMID: 28855629.

Lucy KA, Wang B, Schuman JS, Bilonick RA, Ling Y, Kagemann L, Sigal IA, Grulkowski I, Liu JJ, Fujimoto JG, Ishikawa H, Wollstein G. 2017. Thick Prelaminar Tissue Decreases Lamina Cribrosa Visibility. Invest Opthalmol Vis Sci. 1751-1757. PMID: 28411159.

Dong ZM, Wollstein G, Wang B, Schuman JS. 2017.  Adaptive optics optical coherence tomography in glaucoma. Prog Retin Eye Res. 76-88. PMID: 28029241.

Murphy MC, Conner IP, Teng CY, Lawrence JD, Safiullah Z, Wang B, Bilonick RA, Kim SG, Wollstein G, Schuman JS, Chan KC. 2016. Retinal Structures and Visual Cortex Activity are Impaired Prior to Clinical Vision Loss in Glaucoma. Sci Rep. PMID: 275510406.

Wang B, Lucy KA, Schuman JS, Sigal IA, Bilonick RA, Lu C, Liu J, Grulkowski I, Nadler Z, Ishikawa H, Kagemann L, Fujimoto JG, Wollstein G. Tortuous Pore Path Through the Glaucomatous Lamina Cribrosa. Sci Rep. 2018 May 8;8(1):7281.

Lucy KA, Wang B, Schuman JS, Bilonick RA, Ling Y, Kagemann L, Sigal IA, Grulkowski I, Liu JJ, Fujimoto JG, Ishikawa H, Wollstein G. Thick Prelaminar Tissue Decreases Lamina Cribrosa Visibility. Invest Ophthalmol Vis Sci. 2017 Mar 1;58(3):1751-1757.

Tran H, Grimm J, Wang B, Smith MA, Gogola A, Nelson S, Tyler-Kabara E, Schuman J, Wollstein G, Sigal IA. Mapping in-vivo optic nerve head strains caused by intraocular and intracranial pressures. Proc SPIE Int Soc Opt Eng. 2017 Feb;10067:100670B.

Dong ZM, Wollstein G, Wang B, Schuman JS. Adaptive optics optical coherence tomography in glaucoma. Prog Retin Eye Res. 2017 Mar;57:76-88.

Wang B, Lucy KA, Schuman JS, Sigal IA, Bilonick RA, Kagemann L, Kostanyan T, Lu C, Liu J, Grulkowski I, Fujimoto JG, Ishikawa H, Wollstein G. Decreased Lamina Cribrosa Beam Thickness and Pore Diameter Relative to Distance From the Central Retinal Vessel Trunk. Invest Ophthalmol Vis Sci. 2016 Jun 1;57(7):3088-92.

Kagemann L, Wang B, Wollstein G, Ishikawa H, Mentley B, Sigal I, Bilonick RA, Schuman JS. Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye. J Vis Exp. 2015 Jun 20;(100):e52611.

Ho LC, Wang B, Conner IP, van der Merwe Y, Bilonick RA, Kim SG, Wu EX, Sigal IA, Wollstein G, Schuman JS, Chan KC. In Vivo Evaluation of White Matter Integrity and Anterograde Transport in Visual System After Excitotoxic Retinal Injury With Multimodal MRI and OCT. Invest Ophthalmol Vis Sci. 2015 Jun;56(6):3788-800.

Song B, Li Y, Wang B, Han Y, Hu Y, Zhang J, Liu C, Hao D, Guo S. Treatment of severe hemifacial atrophy with dorsal thoracic adipofascial free flap and concurrent lipoinjection. J Craniofac Surg. 2015 Mar;26(2):e162-6.

Nadler Z, Wang B, Schuman JS, Ferguson RD, Patel A, Hammer DX, Bilonick RA, Ishikawa H, Kagemann L, Sigal IA, Wollstein G. In vivo three dimensional characterization of the healthy human lamina cribrosa with adaptive optics spectral-domain optical coherence tomography. Invest Ophthalmol Vis Sci. 2014 Sep 16;55(10):6459-66.

Sigal IA, Wang B, Strouthidis NG, Akagi T, Girard MJ. Recent advances in OCT imaging of the lamina cribrosa. Br J Ophthalmol. 2014 Jul;98 Suppl 2(Suppl 2):ii34-9.

Nadler Z, Wang B, Wollstein G, Nevins JE, Ishikawa H, Bilonick R, Kagemann L, Sigal IA, Ferguson RD, Patel A, Hammer DX, Schuman JS. Repeatability of in vivo 3D lamina cribrosa microarchitecture using adaptive optics spectral domain optical coherence tomography. Biomed Opt Express. 2014 Mar 10;5(4): 1114-23.

Wang B, Nevins JE, Nadler Z, Wollstein G, Ishikawa H, Bilonick RA, Kagemann L, Sigal IA, Grulkowski I, Liu JJ, Kraus M, Lu CD, Hornegger J, Fujimoto JG, Schuman JS. Reproducibility of in-vivo OCT measured three-dimensional human lamina cribrosa microarchitecture. PLoS One. 2014 Apr 18;9(4):e95526.

Wang B, Kagemann L, Schuman JS, Ishikawa H, Bilonick RA, Ling Y, Sigal IA, Nadler Z, Francis A, Sandrian MG, Wollstein G. Gold nanorods as a contrast agent for Doppler optical coherence tomography. PLoS One. 2014 Mar 3;9(3):e90690.

Kagemann L, Wang B, Wollstein G, Ishikawa H, Nevins JE, Nadler Z, Sigal IA, Bilonick RA, Schuman JS. IOP elevation reduces Schlemm's canal cross sectional area. Invest Ophthalmol Vis Sci. 2014 Mar 25;55(3):1805-9.

Wang B, Nevins JE, Nadler Z, Wollstein G, Ishikawa H, Bilonick RA, Kagemann L, Sigal IA, Grulkowski I, Liu JJ, Kraus M, Lu CD, Hornegger J, Fujimoto JG, Schuman JS. In vivo lamina cribrosa micro-architecture in healthy and glaucomatous eyes as assessed by optical coherence tomography. Invest Ophthalmol Vis Sci. 2013 Dec 19;54(13):8270-4.

Nadler Z, Wang B, Wollstein G, Nevins JE, Ishikawa H, Kagemann L, Sigal IA, Ferguson RD, Hammer DX, Grulkowski I, Liu JJ, Kraus MF, Lu CD, Hornegger J, Fujimoto JG, Schuman JS. Automated lamina cribrosa microstructural segmentation in optical coherence tomography scans of healthy and glaucomatous eyes. Biomed Opt Express. 2013 Oct 24;4(11):2596-608.

Wang B, Tran H, Smith MA, Kostanyan T, Schmitt SE, Bilonick RA, Jan NJ, Kagemann L, Tyler-Kabara EC, Ishikawa H, Schuman JS, Sigal IA, Wollstein G. In vivo effects of intraocular and intracranial pressures on the lamina cribrosa microstructure. PLoS One. 2017 Nov 21;12(11):e0188302.

Trainee Name: David Wheeler
Trainee: Past
Faculty Member: Romero, Guillermo
Publications:

Treat AC, Wheeler DS, Stolz DB, Tsang M, Friedman PA, Romero G. The PDZ Protein Na+/H+ Exchanger Regulatory Factor-1 (NHERF1) Regulates Planar Cell Polarity and Motile Cilia Organization. PLoS One. 2016 Apr 7;11(4):e0153144. doi: 10.1371/journal.pone.0153144. PMID: 27055101; PMCID: PMC4824468.

Wheeler DS, Underhill SM, Stolz DB, Murdoch GH, Thiels E, Romero G, Amara SG. Amphetamine activates Rho GTPase signaling to mediate dopamine transporter internalization and acute behavioral effects of amphetamine. Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):E7138-47. doi: 10.1073/pnas.1511670112. Epub 2015 Nov 9. PMID: 26553986; PMCID: PMC4697400.

Fouquerel E, Goellner EM, Yu Z, Gagné JP, Barbi de Moura M, Feinstein T, Wheeler D, Redpath P, Li J, Romero G, Migaud M, Van Houten B, Poirier GG, Sobol RW. ARTD1/PARP1 negatively regulates glycolysis by inhibiting hexokinase 1 independent of NAD+ depletion. Cell Rep. 2014 Sep 25;8(6):1819-1831. doi: 10.1016/j.celrep.2014.08.036. Epub 2014 Sep 15. PMID: 25220464; PMCID: PMC4177344.

Romero G, Sneddon WB, Yang Y, Wheeler D, Blair HC, Friedman PA. Parathyroid hormone receptor directly interacts with dishevelled to regulate beta-Catenin signaling and osteoclastogenesis. J Biol Chem. 2010 May 7;285(19):14756-63. doi: 10.1074/jbc.M110.102970. Epub 2010 Mar 8. PMID: 20212039; PMCID: PMC2863183.

Wheeler D, Garrido JL, Bisello A, Kim YK, Friedman PA, Romero G. Regulation of parathyroid hormone type 1 receptor dynamics, traffic, and signaling by the Na+/H+ exchanger regulatory factor-1 in rat osteosarcoma ROS 17/2.8 cells. Mol Endocrinol. 2008 May;22(5):1163-70. doi: 10.1210/me.2007-0461. Epub 2008 Jan 17. PMID: 18202147; PMCID: PMC2366176.

Wheeler D, Sneddon WB, Wang B, Friedman PA, Romero G. NHERF-1 and the cytoskeleton regulate the traffic and membrane dynamics of G protein-coupled receptors. J Biol Chem. 2007 Aug 24;282(34):25076-87. doi: 10.1074/jbc.M701544200. Epub 2007 Jun 27. PMID: 17599914.

Trainee Name: Rachel M Whelan
Trainee: Past
Faculty Member: Bunker, Clareann
Publications:

Kusneniwar GN, Whelan RM, Betha K, Robertson JM, Ramidi PR, Balasubramanian K, Kamasamudram V, Haggerty CL, Bunker CH, Reddy PS. Cohort Profile: The Longitudinal Indian Family hEalth (LIFE) Pilot Study, Telangana State, India. Int J Epidemiol. 2017 Jun 1;46(3):788-789j. doi: 10.1093/ije/dyw174. PMID: 27649805; PMCID: PMC5837391.

Yee LJ, Tang YM, Kleiner DE, Wang D, Im K, Wahed A, Tong X, Rhodes S, Su X, Whelan RM, Fontana RJ, Ghany MG, Borg B, Liang TJ, Yang H; Virahep-C Study Group. Myxovirus-1 and protein kinase haplotypes and fibrosis in chronic hepatitis C virus. Hepatology. 2007 Jul;46(1):74-83. doi: 10.1002/hep.21636. PMID: 17526009.

Trainee Name: Ryan Williamson, MD, PhD
Trainee: Past
Faculty Member: Matthew Smith, PhD
Publications:

Williamson RC, Cowley BR, Litwin-Kumar A, Doiron B, Kohn A, Smith MA, Yu BM. 2016. Scaling Properties of Dimensionality Reduction for Neural Populations and Network Models. PLoS Comput Biol. PMID: 27926936.

Bittner SR, Williamson RC, Snyder AC, Litwin-Kumar A, Doiron B, Chase SM, Smith MA, Yu BM. 2017. Population activity structure of excitatory and inhibitory neurons. PLoS One. PMID: 28817581.

Cowley B, Williamson R, Clemens K, Smith M, Yu B. (2017) Adaptive Sampling for a Population of Neurons. Neural Information Processing Systems Conference. Accepted.

Williamson RC, Doiron B, Smith MA, Yu BM. Bridging large-scale neuronal recordings and large-scale network models using dimensionality reduction. Curr Opin Neurobiol. 2019 Apr;55:40-47. doi: 10.1016/j.conb.2018.12.009. Epub 2019 Jan 22. PMID: 30677702; PMCID: PMC6548625.

Issar D, Williamson RC, Khanna SB, Smith MA. A neural network for online spike classification that improves decoding accuracy. J Neurophysiol. 2020 Apr 1;123(4):1472-1485. doi: 10.1152/jn.00641.2019. Epub 2020 Feb 26. PMID: 32101491; PMCID: PMC7191521.

Cowley BR, Snyder AC, Acar K, Williamson RC, Yu BM, Smith MA. Slow Drift of Neural Activity as a Signature of Impulsivity in Macaque Visual and Prefrontal Cortex. Neuron. 2020 Nov 11;108(3):551-567.e8. doi: 10.1016/j.neuron.2020.07.021. Epub 2020 Aug 17. PMID: 32810433.

Mortensen, P., Enzor, R., Keppel, K., Williamson, R., Jones, P., Nkrumah, G., Safiullah, Z., Michelson, S., Nadimpalli, S., Shue, A., Waxman, E. The Ophthalmology Mini-Elective Gives Vision to Preclinical Medical Students. MedEdPortal. 2020. https://doi.org/10.15766/mep_2374-8265.11024

Trainee Name: Meghan E. Wilson
Trainee: Past
Faculty Member: Bowser, Robert
Publications:

Wilson ME, Boumaza I, Lacomis D, Bowser R, 2010, Cystatin C: a candidate biomarker for amyotrophic lateral sclerosis, PLoS One, 5(12):e15133.

Wilson ME, Boumaza I, Bowser R, 2013, Measurement of cystatin C functional activity in the cerebrospinal fluid of amyotrophic lateral sclerosis and control subjects, Fluids Barriers CNS, 10(1):15.

Trainee Name: Jeffrey Wong
Trainee: Past
Faculty Member: Kalinski, Pawel
Publications:

Wong JL, Obermajer N, Odunsi K, Edwards RP, Kalinski P. Synergistic COX2 Induction by IFNγ and TNFα Self-Limits Type-1 Immunity in the Human Tumor Microenvironment. Cancer Immunol Res. 2016 Apr;4(4):303-11. doi: 10.1158/2326-6066.CIR-15-0157. Epub 2016 Jan 27. PMID: 26817996; PMCID: PMC4877699.

Obermajer N, Wong JL, Edwards RP, Chen K, Scott M, Khader S, Kolls JK, Odunsi K, Billiar TR, Kalinski P. Induction and stability of human Th17 cells require endogenous NOS2 and cGMP-dependent NO signaling. J Exp Med. 2013 Jul 1;210(7):1433-445. doi: 10.1084/jem.20121277. PMID: 23797095; PMCID: PMC3698515.

Wong JL, Muthuswamy R, Bartlett DL, Kalinski P. IL-18-based combinatorial adjuvants promote the intranodal production of CCL19 by NK cells and dendritic cells of cancer patients. Oncoimmunology. 2013 Sep 1;2(9):e26245. doi: 10.4161/onci.26245. Epub 2013 Sep 12. PMID: 24228233; PMCID: PMC3820810.

Wong JL, Mailliard RB, Moschos SJ, Edington H, Lotze MT, Kirkwood JM, Kalinski P. Helper activity of natural killer cells during the dendritic cell-mediated induction of melanoma-specific cytotoxic T cells. J Immunother. 2011 Apr;34(3):270-8. doi: 10.1097/CJI.0b013e31820b370b. PMID: 21389871; PMCID: PMC3057371.

Wong JL, Berk E, Edwards RP, Kalinski P. IL-18-primed helper NK cells collaborate with dendritic cells to promote recruitment of effector CD8+ T cells to the tumor microenvironment. Cancer Res. 2013 Aug 1;73(15):4653-62. doi: 10.1158/0008-5472.CAN-12-4366. Epub 2013 Jun 12. PMID: 23761327; PMCID: PMC3780558.

Obermajer N, Wong JL, Edwards RP, Odunsi K, Moysich K, Kalinski P. PGE(2)-driven induction and maintenance of cancer-associated myeloid-derived suppressor cells. Immunol Invest. 2012;41(6-7):635-57. doi: 10.3109/08820139.2012.695417. PMID: 23017139.

Trainee Name: Genevieve Woodard
Trainee: Past
Faculty Member: Sutton-Tyrrell, Kim
Publications:

Cooper JN, Fried L, Tepper P, Barinas-Mitchell E, Conroy MB, Evans RW, Mori Brooks M, Woodard GA, Sutton-Tyrrell K. Changes in serum aldosterone are associated with changes in obesity-related factors in normotensive overweight and obese young adults. Hypertens Res. 2013 Oct;36(10):895-901. doi: 10.1038/hr.2013.45. Epub 2013 May 9. PMID: 23657296; PMCID: PMC3766434.

Cooper JN, Tepper P, Barinas-Mitchell E, Woodard GA, Sutton-Tyrrell K. Serum aldosterone is associated with inflammation and aortic stiffness in normotensive overweight and obese young adults. Clin Exp Hypertens. 2012;34(1):63-70. doi: 10.3109/10641963.2011.618200. Epub 2011 Oct 18. PMID: 22007645; PMCID: PMC3262912.

Woodard GA, Brooks MM, Barinas-Mitchell E, Mackey RH, Matthews KA, Sutton-Tyrrell K. Lipids, menopause, and early atherosclerosis in Study of Women's Health Across the Nation Heart women. Menopause. 2011 Apr;18(4):376-84. doi: 10.1097/gme.0b013e3181f6480e. PMID: 21107300; PMCID: PMC3123389.

Woodard GA, Mehta VG, Mackey RH, Tepper P, Kelsey SF, Newman AB, Sutton-Tyrrell K. C-reactive protein is associated with aortic stiffness in a cohort of African American and white women transitioning through menopause. Menopause. 2011 Dec;18(12):1291-7. doi: 10.1097/gme.0b013e31821f81c2. PMID: 21892111; PMCID: PMC3230700.

Woodard GA, Narla VV, Ye R, Cauley JA, Thompson T, Matthews KA, Sutton-Tyrrell K. Racial differences in the association between carotid plaque and aortic and coronary artery calcification among women transitioning through menopause. Menopause. 2012 Feb;19(2):157-63. doi: 10.1097/gme.0b013e318227304b. PMID: 22037218; PMCID: PMC3266995.

Kuipers AL, Kammerer CM, Miljkovic I, Woodard GA, Bunker CH, Patrick AL, Wheeler VW, Newman AB, Zmuda JM. Genetic epidemiology and genome-wide linkage analysis of carotid artery ultrasound traits in multigenerational African ancestry families. Atherosclerosis. 2013 Nov;231(1):120-3. doi: 10.1016/j.atherosclerosis.2013.09.005. Epub 2013 Sep 11. PMID: 24125421; PMCID: PMC3837479.

Lee JJ, Woodard GA, Gianaros PJ, Barinas-Mitchell E, Tepper PG, Conroy MB. Ectopic adiposity is associated with autonomic risk factors and subclinical cardiovascular disease in young adults. Obesity (Silver Spring). 2015 Oct;23(10):2030-6. doi: 10.1002/oby.21138. Epub 2015 Sep 3. PMID: 26333626; PMCID: PMC4587338.

Trainee Name: Gary Yu, MD, PhD
Trainee: Past
Faculty Member: John J Pacella, PhD
Publications:

Yu GZ, Istvanic F, Chen X, Nouraie M, Shiva S, Straub AC, Pacella JJ. Ultrasound-Targeted Microbubble Cavitation with Sodium Nitrite Synergistically Enhances Nitric Oxide Production and Microvascular Perfusion. Ultrasound Med Biol. 2020 Mar;46(3):667-678. doi: 10.1016/j.ultrasmedbio.2019.10.012. Epub 2019 Dec 3. PMID: 31810801; PMCID: PMC7010556.

Istvanic F, Yu GZ, Yu FTH, Powers J, Chen X, Pacella JJ. Sonoreperfusion therapy for microvascular obstruction: A step toward clinical translation. Ultrasound Med Biol. 2020 Mar;46(3):712-720. doi: 10.1016/j.ultrasmedbio.2019.11.011. Epub 2020 Jan 7. PMID: 31924423; PMCID: PMC7010545.

Deng Y, Sun AX, Overholt KJ, Yu GZ, Fritch MR, Alexander PG, Shen H, Tuan RS, Lin H. Enhancing chondrogenesis and mechanical strength retention in physiologically relevant hydrogels with incorporation of hyaluronic acid and direct loading of TGF-β. Acta Biomater. 2019 Jan 1;83:167-176. doi: 10.1016/j.actbio.2018.11.022. Epub 2018 Nov 17. PMID: 30458242; PMCID: PMC6733255.