Laura Molina, PhD

Education & Training

  • University of Florida, BS, 2015
  • University of Pittsburgh, PhD, 2021

Representative Publications

Molina L, Zhu J, Li Q, Pradhan-Sundd T, Krutsenko Y, Sayed K, Jenkins N, Vats R, Bhushan B, Ko S, Hu S, Poddar M, Singh S, Tao J, Sundd P, Singhi A, Watkins S, Ma X, Benos PV, Feranchak A, Michalopoulos G, Nejak-Bowen K, Watson A, Bell A, Monga SP. Compensatory hepatic adaptation accompanies permanent absence of intrahepatic biliary network due to YAP1 loss in liver progenitors. Cell Reports, 2021, Jul 6. PMID: 34233187

Hirsch T*, Pilet J*, Morcrette G*, Roehrig A, Monteiro B, Molina L, Bayard Q, Trépo E, Meunier L, Caruso S, Renault V, Deleuze JF, Fresneau B, Chardot C, Gonzales E, Jacquemin E, Guerin F, Fabre M, Aerts I, Taque S, Laithier V, Branchereau S, Guettier C, Brugières L, Rebouissou S, Letouzé E, Zucman-Rossi J. Integrated genomic analysis identifies driver genes and cisplatin-resistant progenitor phenotype in pediatric liver cancer. Cancer Discovery, 2021, in press. *co-first authors. PMID: 33893148

Bhushan B, Molina L, Koral K, Stoops JW, Mars WM, Banerjee S, Orr A, Paranjpe S, Monga SP, Locker J, Michalopoulos GK. Yap is crucial for CAR-driven hepatocyte proliferation but not for induction of drug metabolism genes in mice. Hepatology, 2020 Aug 13. PMID: 32794202

Ko S, Russell JO, Molina LM, Monga SP. Liver Progenitors and Adult Cell Plasticity in Hepatic Injury and Repair: Knowns and Unknowns. Annu Rev Pathol. 2020 Jan 24;15:23-50. doi: 10.1146/annurev-pathmechdis-012419-032824. Epub 2019 Aug 9.

Bhushan B, Molina L, Koral K, Stoops JW, Mars WM, Banerjee S, Orr A, Paranjpe S, Monga SP, Locker J, Michalopoulos GK. Yap is crucial for CAR-driven hepatocyte proliferation, but not for induction of drug metabolism genes in mice. Hepatology. 2020 Aug 13. doi: 10.1002/hep.31521. Online ahead of print.

Min Q, Molina L, Li J, Adebayo Michael AO, Russell JO, Preziosi ME, Singh S, Poddar M, Matz-Soja M, Ranganathan S, Bell AW, Gebhardt R, Gaunitz F, Yu J, Tao J, Monga SP. β-Catenin and Yes-Associated Protein 1 Cooperate in Hepatoblastoma Pathogenesis. Am J Pathol. 2019 May;189(5):1091-1104. doi: 10.1016/j.ajpath.2019.02.002. Epub 2019 Feb 19.

Molina L, Yang H, Michael AOA, Oertel M, Bell A, Singh S, Chen X, Tao J, Monga SP. Correction: mTOR inhibition affects Yap1-β-catenin-induced hepatoblastoma growth and development. Oncotarget. 2019 Sep 24;10(54):5670. doi: 10.18632/oncotarget.27218. eCollection 2019 Sep 24.

Pradhan-Sundd T, Vats R, Russell JO, Singh S, Michael AA, Molina L, Kakar S, Cornuet P, Poddar M, Watkins SC, Nejak-Bowen KN, Monga SP, Sundd P. Dysregulated Bile Transporters and Impaired Tight Junctions During Chronic Liver Injury in Mice. Gastroenterology. 2018 Oct;155(4):1218-1232.e24. doi: 10.1053/j.gastro.2018.06.048. Epub 2018 Jun 30.

Pradhan-Sundd T, Zhou L, Vats R, Jiang A, Molina L, Singh S, Poddar M, Russell J, Stolz DB, Oertel M, Apte U, Watkins S, Ranganathan S, Nejak-Bowen KN, Sundd P, Monga SP. Dual catenin loss in murine liver causes tight junctional deregulation and progressive intrahepatic cholestasis. Hepatology. 2018 Jun;67(6):2320-2337. doi: 10.1002/hep.29585. Epub 2018 Apr 19.

Molina L, Bell D, Tao J, Preziosi M, Pradhan-Sundd T, Singh S, Poddar M, Luo J, Ranganathan S, Chikina M, Monga SP. Hepatocyte-Derived Lipocalin 2 Is a Potential Serum Biomarker Reflecting Tumor Burden in Hepatoblastoma. Am J Pathol. 2018 Aug;188(8):1895-1909. doi: 10.1016/j.ajpath.2018.05.006. Epub 2018 Jun 18.

Research Interests

Investigating the role of Yes-associated protein 1 (YAP1) in liver development, bile duct formation, and liver regeneration, as well as its interactions with B-catenin signaling in hepatoblastoma tumorigenesis

Research Grants

F30 DK121393, “Elucidating the Critical Functions of Yap1 in the Embryonic Development and Regeneration of the Biliary System," PI: Molina

Student Year

MS4

Career Advisor

JoAnne Flynn, PhD

Thesis Advisor

Paul Monga, MD

Graduate Program

Dissertation Title

YAP1 Signaling in Hepatobiliary Development and Oncogenesis

Trainee

Current

Training Period

2015 - Present

Student Year Term

MS4